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Quantum Medicine update: efferent-afferent and microbiotica imbalances in multiple chemical sensitivity and fibromyalgia.

An ecological view of multiple chemical sensitivity (MCS) and fibromyalgia recognizes that the delicate symbiotic equilibrium of commensal microbiotica is disrupted. The war on microbes and the simplistic "nuke the microbe" mindset has caused a rising incidence of MCS, asthma, eczema, allergies, and inflammatory disorders like fibromyalgia. (1), (2) This unremitting assault on microbes has wiped out billions of beneficial commensal cells that synthesize vitamin K, folic acid, synbiotic nutrient detoxifiers, immunological weaponry (lysozymes, bacteriocins, lactoferrin, and transferren), neuronutrients, and hormone precursor nutrients.

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Our 90 trillion commensal cells outnumber human cells ten to one, play a prominent role in resistance to pathogenic microbes, and are an integral--not aberrant- part of the healthy ecology of microbial life. However, changes in global ecology, food, and climate, along with mutant pathogens, result in dysbiosis and efferent-generated inflammation. The dysbiotic gastrointestinal (GI) tract cannot maintain stable ecological niches, because the complex, dynamic, and spatially diversified microbiotica and their microbiome of collective genomes are disrupted. (3-5) The microbiome is 100-fold larger than that of its host and culture-based assays, and a variety of molecular methods that include fluorescent in situ hybridization, terminal restriction fragment length polymorphisms, microarrays, and direct sequencing reveal exciting new data on how human microbiotica can detoxify the body, fight inflammation, and nourish afferent neurons that regenerate the body. (6), (7)

The mutually beneficial commensal/human cell symbiosis requires colonization and proper afferent control of digestion. When this happens, commensal microbiotica become nutrient factories, producing detoxifying compounds and ample immunological weaponry. However, in today's toxic world, afferent neurons are dominated by efferent-generated cytokine inflammation, leaving sick patients unable to digest food into nutrients that nourish commensals. When afferent neurons are unable to control the motility and mobility of the gastroduodenal juncture, we store rather than excrete toxins, staying locked in the efferent cholinergic anti-inflammatory pathway.

Commensal cells are master physiological chemists, employing a broad range of strategies to nourish and manipulate human cells via communication known as quorum sensing. (8-10) Quorum sensing is disrupted when we employ antimicrobial pharmaceuticals or natural anti-infectives. This mindset is hard to understand when scientists are telling us that, out of our 90 trillion microbes functioning as persistent commensal colonists and symbionts to provide a mutually beneficial relationship with the host, only 70 are pathogenic. (11-13)

Dysbiosis causes persistent efferent inflammation and opportunistic infections that favor pathogenesis. (12) Thus, conquering MCS, fibromyalgia, and other inflammation-driven disorders means that we have to abandon notions that pit host against microbe and focus on an ecological view that recognizes the interdependence of hosts with their microbiotica for each other's survival.

Immunological competence depends on a quorum of commensals or proper colonization to bolster innate and adaptive immunity and maintain mucosal homeostasis. (14) Commensal microbiotica are our close allies, and we must recolonize and nourish them so that this vast, complex, and dynamic consortium of cells can colonize and approach a microbial density of 10 (12) organisms per gram. The quorum relationship between human cells and commensals represents millions of years of peaceful coexistence before the advent of antibiotics. Could an absence of these powerful commensal detoxifiers and afferent nutrient regenerators be behind the constant inflammation and pain of fibromyalgia and the defective detoxification functions of MCS victims?

Commensals produce a goldmine of antitoxin, anti-inflammatory, and anticancer agents that are integral to the body's immunological weaponry. (16-25) It took me three decades of research with probiotic colonizers to understand how to recolonize microbiotica with quorum nutrition so that commensals could find permanent residence in the gut. Once they successively thrive and the gut mucosa are stabilized with quorum nutrition, they can express their rich genetic diversity to heal and regenerate the body. Plus, commensal cells are vast reservoirs of essential hard-to-get nutrients and anti-inflammatory compounds that soothe inflammation with more clout than any kind of antiinflammatory pharmaceutical or nutraceutical.

Efferent neuron dominance always depresses afferent control of digestion and detoxification, making it impossible for commensals to colonize and survive. Since commensals feed human cells, we become deficient. In turn, the liver absorbs maldigestive byproducts which elicit stagnant damp heat that we have found in hundreds of patients with MCS and fibromyalgia. Thus, the maldigestion dilemma warrants that commensal nourishment be in a quorum synbiotic format so that they can rapidly feed, cleanse, and fortify themselves for colonization. My original research findings are supported by studies that reveal how quorum synbiotics are beneficial in cases of severe acute pancreatitis, chronic hepatitis, abdominal surgery, liver transplantation, and abnormal calcification. (22-25)

Afferents are busy multitaskers, guiding and regulating digestive physiology and many facets of human physiology as they listen to the quorum language of commensal cells. (26-31) Until recently, studies of afferent neurons examined only a few cells sitting in a Petri dish. Now scientists are figuring out how to observe living cells and learning more about their abilities as well as how to pay more attention to their quorum language. Fathoming the precise ratios of quorum-fermented probiotics that could actually colonize the gut and reestablish a peaceful coexistence of friendly cellular quorum communication is the ultimate clinical goal. Commensal cellucide inhibits afferents and activates efferents to generate huge amounts of cytokine inflammation, causing the immune system to go haywire and attack the body's own neurons and tissues. Clearly, restoring efferent-afferent balance by restoring commensal microbiotica balances the Thl/Th-2 immune response so that we have a speedier and more efficient immune response. (19-21)

In summary, commensal-probiotic colonization has the potential to reboot a misfiring immune system and restore the human ecosystem. The pharmaceutical war on microbes and early hope for unprecedented cures gave way to tragic deaths, autoimmune disease like juvenile diabetes and multiple sclerosis, and disorders like MCS and fibromyalgia. Our germicidal zeal has caused us to become deregulated, inflamed, malnourished, and toxic and has even confused and riled up immune cells to zap our bodies' own tissues. Obsessing on pathogenic microbes has blinded us to ways we can enlist commensal cells to bolster health.

The author is supported in part by American Academy of Quantum Medicine, a nonprofit foundation dedicated to frontier research in Quantum Medicine & Quorum Nutrition. The author is affiliated with QuantaFoods LLC, a firm that develops and researches probiotics and fermentation to develop novel forms of quorum nutrition and is a research consultant for several independent, university-based laboratories. The content of this article was neither influenced nor constrained by these facts.

Notes

(1.) Bjorksten B. Effects of intestinal microflora and the environment on the development of asthma and allergy. Springer Semin Immunopathol. 2004;25:257-270.

(2.) Kalliomaki M et al. Role of intestinal flora in the development of allergy. Curr Opin Allergy Clin Immunol. 2003;3:15-20.

(3.) Backhed F et al. The gut microbiotica as an environmental factor that regulates fat storage. Proceedings of the National Academy of Sciences, 2004,101:44, 15718-23.

(4.) Savage, DC. Microbial ecology of the gastrointestinal tract. Annual Reviews in Microbiology, 1977,31:107-133.

(5.) XuJ, Gordon JL. Honorthy symbionts. Proc Natl Acad Sci. 2003;100(18):10452-10459.

(6.) Breitbart M et al. Metagenomic analysis of an uncultured viral community from human feces. J Bacteriol. 2003; 185(20): 6220-6223.

(7.) Winter C et al. Impact of virioplankton on archaeal and bacterial community richness as assessed in seawater batch cultures. Appl Environ Microbiol 2004; 70(2):804-813.

(8.) Blassler BL. How bacteria talk to each other. Regulation of gene expression by quorum sensing. Curr Opin Microbiol. 1999;2(6):582-587.

(9.) Whiteley M et al. identification of genes controlled by quorum sensing. Proc Natl Acad Sci. 1999;96:13904-13909.

(10.) You YS et al. Use of bacterial quorum sensing components to regulate gene expression in plants. Plant Physiol. 2006;152:1155-1167.

(11.) Blaser M. Ecology of H pylori in the human stomach. J Clin Invest.1997;100 (4):759-762.

(12.) Merrell DS et al. Frontal and stealth attack strategies in microbial pathogenesis. Nature. 2004;430:250-256.

(13.) Lederberg J. infectious history. Science. 2000;288:287-293.

(14.) Rumbo M et al. FEBS Letters. 2009;580(12):2976-2984.

(15.) Epstein O. Green machine. J R Soc Med. 2005 May; 98(5):203-205.

(16.) Castagliuolo I et al. Saccharomyces boulardii protease inhibits Clostridium difficile toxin A effects in the rat ileum. Infect Immunol. 1996;64:5225-5232.

(17.) Czerucka D et al. Saccharomyces boulardii inhibits secretagogue-mediated adenosine 3,5--cyclic monophosphate induction in intestinal cells. Gastroenterology. 1994; 106: 65-72.

(18.) Bengmark S. Pre-, pro-, and synbiotics. Curr Opin Clin Nutr Metab Care. 2001;4(6).

(19.) Yanick P Man-made chemicals: the hidden role of the lymphatic system in the genesis of polycystic ovary, fibrocystic breast disease, and breast cancer. Townsend Lett. April 2009.

(20.) Yanick P. Restoring immunity, the autonomic nervous system, and bioenergetic reciprocity for a fuller expression of innate healing in naturopathic medicine. Townsend Lett. April 2007.

(21.) Yanick P. Strengthening innate immunological weaponry against cancer. Townsend Lett. Aug-Sept 2007.

(22.) Bengmark S. 2002. Use of pro-, pre- and synbiotics in the ICU--future options. Chapter 34 in: Shikora SA, Martindale RG, Schwaitzberg SD, eds. Nutritional Considerations in the Intensive Care Unit--Science, Rationale and Practice. Dubuque, IA: Kendall/Hunt Publishing Company:381-399.

(23.) Bengmark S 2002. Gut microbial ecology in critical illness: ... a role for pre-, pro-, and synbiotics. Curr Opin Crit Care. 2002: 8:145-151.

(24.) Bengmark S. 2002. Aggressive peri- and intraoperative enteral nutrition--Strategy for the future. Chapter 33 in: Shikora SA, Martindale RG, Schwaitzberg SD, eds. Nutritional Considerations in the Intensive Care Unit--Science, Rationale and Practice. Dubuque, IA: Kendall/Hunt Publishing Company:365-380.

(25.) Bengmark S 2001. Op cit.

(26.) Tougas G et al. Evidence of impaired afferent vagal function in patients with diabetes gastroparesis. Pacing Clin Electrophysiol. 1992;15:1597-1602.

(27.) Carlos Bernal-Mizrachi et al. An afferent vagal nerve pathway links hepatic PPAR[alpha]. activation to glucocorticoid-induced insulin resistance and hypertension. Cell Metab. 2007: 5:(2);91-102.

(28.) Uno K et al. Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. Science. 2006;312:1656-1659.

(29.) Warne JP et al. Afferent signalling through the common hepatic branch of the vagus inhibits voluntary lard intake and modifies plasma metabolite levels in rats. J Physiol 2007;583(2):455-467.

(30.) Blalock JE. Harnessing a neural-immune circuit to control inflammation and Shock. J Exp Med. 2002;195:F25-F28.

(1.) Pavlov VA et al. The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation. Mol Med. 2003 May-Aug;9(5-8): 125-134.

[C] 2009 Paul Yanick, Jr., PhD

by Paul Yanick, Jr., PhD

American Academy of Quantum Medicine

www.aaqm.org
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Date:Nov 1, 2009
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