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Q / Can CBT effectively treat adult insomnia disorder?

EVIDENCE-BASED ANSWER

A / YES. Cognitive behavioral therapy AI (CBT) administered individually, in a group setting, or on the internet is effective for treating insomnia in adults compared with control (strength of recommendation [SOR]: A, meta-analyses).

CBT is comparable to pharmacotherapy for improving measures of sleep (SOR: A, comparative meta-analysis).

CBT produces sustainable improvements in subjective sleep quality for adults with comorbid insomnia (SOR: A, meta-analysis).

Evidence summary

Three meta-analyses that included only randomized controlled trials (RCTs) compared various CBT delivery methods with controls (wait-listed for treatment or general sleep hygiene education) to assess sleep outcomes for adults with insomnia. (1-3) TABLE 1 (1-3) summarizes the results.

CBT is comparable to pharmacotherapy

A 2002 comparative meta-analysis of 21 RCTs with a total of 470 patients examined the effectiveness of CBT (stimulus control and/or sleep restriction) compared with pharmacotherapy (benzodiazepines or benzodiazepine agonists) for treating primary insomnia of longer than one month's duration in adults with no comorbid medical or psychiatric diagnoses. (4) The CBT group received intervention over an average of 5 weeks, and the pharmacotherapy group received intervention over an average of 2 weeks.

CBT produced greater reductions in sleep onset latency than pharmacotherapy based on mean weighted effect size (1.05 vs 0.45 weighted effect size; 95% confidence interval, 0.17-1.04; P=.01). Although both CBT and pharmacotherapy improved sleep outcomes, no statistical differences were found in wake after sleep onset time, total sleep time, number of awakenings, or sleep quality ratings (TABLE 2 (4)).

CBT has significant benefit for comorbid insomnia

A 2015 meta-analysis of 23 studies enrolling a total of 1379 adults with a number of illnesses (chronic pain, alcohol dependence, breast cancer, psychiatric disorders, chronic obstructive pulmonary disease, fibromyalgia) and comorbid insomnia investigated the qualitative effectiveness of individual or group CBT therapy.5 Subjects received at least 4 face-to-face sessions and at least 2 components of CBT.

The primary outcome showed that sleep quality improved, as measured by a 6.36-point reduction in the Insomnia Severity Index (ISI; a 7-question scale on which 0=no insomnia and 28=severe insomnia) and a 3.3-point reduction in the Pittsburgh Sleep Quality Index (PSQI; a 7-category assessment tool on which 0=perfect quality and 21=poor quality). The effect size was large for both ISI and PSQI, as indicated by standard mean differences greater than 0.8 (1.22 and 0.88, respectively) and was sustained for as long as 18 months.

Recommendations

The American College of Physicians strongly recommends that all adult patients receive CBT as initial treatment for chronic insomnia disorder. It can be performed in multiple settings, including the primary care setting. Compared with hypnotics, CBT is unlikely to have any adverse effects. (6)

Steven Fox, M D University of Tennessee College of Medicine Chattanooga

Joan Nashelsky, MLS Family Physicians Inquiries Network, Iowa City, Iowa

Michael Jack, BA Erlanger Health System Medical Library, Chattanooga, Tenn

ASSISTANT EDITOR

Rick Guthmann, MD, MPH

Advocate Illinois Masonic Family Medicine Residency, Chicago

References

(1.) Trauer I, Qian M, Doyle J, et al. Cognitive behavioral therapy for chronic insomnia: a systematic review and meta-analysis. Ann Intern Med. 2015;163:191-204.

(2.) Koffel E, Koffel I, Gehrman P. A meta-analysis of group cognitive behavioral therapy for insomnia. Sleep Med Rev. 2015;19:6-16.

(3.) Ye Y, Chen N, Chen I, et al. Internet-based cognitive-behavioral therapy for insomnia (ICBT-i): a meta-analysis of randomized controlled trials. BM] Open. 2016;6:e010707.

(4.) Smith M, Perlis M, Park S, et al. Comparative meta-analysis of pharmacotherapy and behavior therapy for persistent insomnia. Am J Psychiatry. 2002;159:5-11.

(5.) Geiger-Brown J, Rogers V, Liu W, et al. Cognitive behavioral therapy in persons with comorbid insomnia: a meta-analysis. Sleep Med Rev. 2015;23:54-67.

(6.) Qaseem A, Kansagara D, Forciea M, et al. Management of chronic insomnia disorder in adults: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2016;165: 125-133.
TABLE 1
CBT outcomes for insomnia

Type of insomnia   Type of insomnia   Age (yrs)   Treatment
(number of RCTs,   CBT *                          duration
subjects)

Primary            Group or           20-77       [greater than
(20, 1162) (1)     individual                     or equal to]
                                                  2 sessions

Comorbid           Group              45-68       4-8 sessions
and primary
(8, 659) (2)

Comorbid and       Internet           39-60       5-9 wk
noncomorbid
(14, 1604) (3)

Type of insomnia   Follow-up   Outcomes        P-value
(number of RCTs,   time (mo)   compared with
subjects)                      control (min)

Primary            3-12        SOL: -19        .04
(20, 1162) (1)                 WASO: -26       .026
                               TST: +7.6       .42
                               SE%: +10%       .017

Comorbid           3-12        SOL: -27        <.01
and primary                    WASO: -41       <.01
(8, 659) (2)                   TST:+19         <.01
                               SE%: +13%       <.01

Comorbid and       1-12        SOL: -19        <.001
noncomorbid                    WASO: -31       <.001
(14, 1604) (3)                 TST: +35        <.001
                               SE%: +10%       <.001

CBT, cognitive behavioral therapy; RCTs, randomized controlled
trials; SE, sleep efficiency (sleep time/time in bed); SOL, sleep
onset latency (how long it takes to fall asleep); TST, total sleep
time; WASO, wake after sleep onset (how long it takes to fall
back to sleep after waking up).

* CBT using at least 2 of 5 modalities
(cognitive therapy, sleep hygiene, sleep
restriction, stimulus control, relaxation).

TABLE 2
How pharmacotherapy compares with CBT
for persistent insomnia (4)

Sleep outcome   Pharmacotherapy   CBT
measure

                Mean change in minutes (effect size)

SOL             -14.5 (0.45)      -23.31 (1.05 *)
WASO            -25.6 (0.89)      -38.4 (1.03)
TST             40.5 (0.84)       19.6 (0.46)

CBT, cognitive behavioral therapy; SOL, sleep onset latency;
TST, total sleep time; WASO, wake after sleep onset.

* Behavioral therapy showed greater reductions in sleep
onset latency than pharmacotherapy (t=2.88, degree of
freedom=20.62; P=.01).
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Title Annotation:CLINICAL INQUIRIES; cognitive behavioral therapy
Author:Fox, Steven; Nashelsky, Joan; Jack, Michael; Guthmann, Rick
Publication:Journal of Family Practice
Article Type:Report
Date:Jul 1, 2018
Words:933
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