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PsychoGenics receives licenses from Mayo Clinic and TET Systems for rTg4510 tauopathy mouse model.

M2 EQUITYBITES-February 4, 2014-PsychoGenics receives licenses from Mayo Clinic and TET Systems for rTg4510 tauopathy mouse model


PsychoGenics, a provider of a range of standard and customised preclinical services, has received licenses from Mayo Clinic and TET Systems for the rTg4510 tauopathy mouse model, it was reported yesterday.

The rTg4510 mouse model expresses the P301L mutation in the tau gene associated with frontotemporal dementia and Parkinsonism linked to chromosome 17. Transgene expression in this model is made through the tetracycline-operon responsive element, which is licensed from TET Systems, and is reversibly suppressed after treatment with doxycycline.

Dr Karen K Hsiao Ashe, Dr Jada Lewis and Dr Michael Hutton have developed the rTg4510 mice that exhibit many salient characteristics of hereditary human dementia in an age-dependent manner covering cognitive impairment, motor deficits, the presence of neurofibrillary tangles and neuronal loss in the forebrain.

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Publication:M2 EquityBites (EQB)
Date:Feb 4, 2014
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