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Psoriasis and Guillain-Barre Syndrome: Incidental or Associated?

Guillain-Barre syndrome (GBS) is an acute autoimmune inflammatory demyelinating polyneuropathy. (1) Psoriasis is an inflammatory disease characterized by lesions of the skin, nails, and joints. (2) In this article, we report a male patient with psoriasis presenting with GBS.

A 66-year-old male patient presented to the emergency department with complaints of numbness, tingling, and weakness in his legs since last two hours. The patient had a history of chronic plaque psoriasis affecting the lower limbs (Figure 1). On neurological examination, his dorsiflexor strength of right ankle was 4/5 and eversion strength of left ankle was 3/5. His vibratory sense was decreased on lumbar 3 and 4 dermatomes in left lower extremity. Deep tendon reflexes were normal on upper extremities; but patella reflexes were decreased in the lower extremities. The patient's laboratory studies did not reveal any infectious process. His cerebrospinal fluid studies revealed protein count of 35.8 mg/dL and glucose of 60 mg/dL with normal cell count. Cerebrospinal fluid cultures were sterile. Nerve conduction studies of the patient reported early stage acute inflammatory demyelinating polyneuropathy (Table 1). He fulfilled the Brighton criteria for GBS. (3) After GBS diagnosis, therapy with intravenous human immunoglobulin was instituted in addition to methotrexate (15 mg/week), folic acid (5 mg/week), and pregabalin (600 mg/day). He recovered gradually over the next three weeks gaining a muscle power of 5 in lower limbs. He showed significant improvement functionally and became able to walk independently. He was discharged from the hospital and the patient was called for a control visit two weeks later.

Neurologic disorders of psoriasis are rare manifestations. (4-6) To our knowledge, this is the first psoriasis patient presenting with GBS. When neurologic dysfunctions develop in patients with psoriasis history, the possibility of GBS should be kept in mind and the patients should be examined in this respect.

doi: 10.5606/ArchRheumatol.2017.6296

Declaration of conflicting interests

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.


The authors received no financial support for the research and/or authorship of this article.


(1.) Li Z, Shen J, Liang J, Feng F. Successful surgical treatment of scoliosis secondary to Guillain-Barre syndrome: Case report. Medicine (Baltimore) 2016:95:3775.

(2.) Atyabi A, Shirbeigi L, Eghbalian F. Psoriasis and Topical Iranian Traditional Medicine. Iran J Med Sci 2016;41:54.

(3.) Fokke C, van den Berg B, Drenthen J, Walgaard C, van Doorn PA, Jacobs BC. Diagnosis of GuillainBarre syndrome and validation of Brighton criteria. Brain 2014;137:33-43.

(4.) Polienko EM, Pavlova TI, Getagazov ME. Neurologic disorders in patients with psoriatic arthropathy. Revmatologiia (Mosk) 1988;1:43-7. [Abstract]

(5.) Bartsch T, Rempe T, Wrede A, Leypoldt F, Bruck W, Adams O, et al. Progressive neurologic dysfunction in a psoriasis patient treated with dimethyl fumarate. Ann Neurol 2015;78:501-14.

(6.) Zhu TH, Nakamura M, Farahnik B, Abrouk M, Lee K, Singh R, et al. The Role of the Nervous System in the Pathophysiology of Psoriasis: A Review of Cases of Psoriasis Remission or Improvement Following Denervation Injury. Am J Clin Dermatol 2016;17:257-63.

Betul SARGIN, Gulcan GURER

Department of Physical Medicine and Rehabilitation, Medical Faculty of Adnan Menderes University, Aydin, Turkey

Received: November 24, 2016 Accepted: December 05, 2016 Published online: April 11, 2017

Correspondence: Betul Sargin, MD. Adnan Menderes Universitesi Tip Fakultesi Fiziksel Tip ve Rehabilitasyon Anabilim Dali, 09010 Aydin, Turkey. Tel: +90 554-592 94 30 e-mail:

Caption: Figure 1. Chronic plaque psoriasis affecting the lower limbs.
Table 1. Nerve conduction study

Anatomic site         Amplitude   Latency     Conduction
                        (mV)       (ms)     velocity (m/sec)

Right median motor
  Wrist                 11.2        2.6           52.3
  Elbow                  8.9        7.0
Right ulnar motor
  Wrist                 19.8       1.50
  Elbow                 19.1        6.2
  Axilla                18.6        7.3
  Erb's point           14.9       10.4
Right tibial motor
  Ankle                  6.5        7.6           32.0
  Knee                   4.3       17.9
Left tibial motor
  Ankle                  1.6        4.4           35.1
  Knee                   0.4       15.8
Left peroneal motor
  Ankle                  4.5        4.2           36.1
  Knee                   4.5       12.5           62.5
Left sural sensory
  Ankle                  4.0        3.2           41.9
  Calf                   3.7        3.1
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Author:Sargin, Betul; Gurer, Gulcan
Publication:Turkish Journal of Rheumatology
Article Type:Letter to the editor
Date:Sep 1, 2017
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