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Pseudomonas aeruginosa bacteraemia.

Pseudomonas aeruginosa bacteraemia (PAB) is still primarily a nosocomial infection, but the numbers of community-acquired cases are increasing, especially in patients with AIDS. Perovic and colleagues found that PAB is a major problem at Chris Hani Baragwanath Hospital. (5)

In their study the most common underlying conditions were burns, HIV infection, trauma and haematological malignancies. More than a third of episodes were catheter related. In 91 bacteraemic episodes the mortality rate was 46.8% for the 79 patients whose outcome was known.

For organism-directed therapy, appropriate treatment was significantly associated with reduced mortality. Combination therapy is not necessarily more advantageous than monotherapy.

The presence of multidrug-resistant (MDR) strains and evidence of transmissions in specialised ICU facilities at the hospital suggest that the extensive use of antimicrobial agents may have played a selective role, while prolonged stay created opportunities for selection of MDR strains.


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(4.) Brink A, Feldman C, Richards G, Moolman J, Senekal M. Emergence of extensive drug resistance (XDR) among Gram-negative bacilli in South Africa looms nearer. S Afr Med J 2008; 98:....

(5.) Perovic O, Koornhof HJ, Crewe-Brown HH, Duse AG, van Nierop W, Galpin JS. Pseudomonas aeruginosa bacteraemia in an academic hospital in South Africa. S Afr Med J 2008; 98:....
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Publication:South African Medical Journal
Article Type:Brief article
Geographic Code:6SOUT
Date:Aug 1, 2008
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