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Provision of Nucleotide Second Messenger Signaling in Bacteria.

Tenders are invited for Provision of Nucleotide Second Messenger Signaling in Bacteria.

The Senate of the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)

has established the Priority Programme Nucleotide Second Messenger Signaling in Bacteria

(SPP 1879) which is intended to run for six years. This call invites proposals for the first threeyear

funding period.

Nucleotide second messengers are key components of the signal transduction networks that

link sensory input with the regulatory responses of all living cells. Despite having provided early

textbook examples such as cAMP and ppGpp, the astonishing diversity, mechanistic complexity

and pervasive roles of bacterial second messenger signaling have become apparent only

recently. This progress has been triggered by the discovery of the ubiquitous cyclic dinucleotide

cA[degrees]diA[degrees]GMP, a bacterial lifeA[degrees]style signaling molecule that controls biofilm formation, cell cycle

progression, development and virulence. Research on cA[degrees]diA[degrees]GMP has led to entirely new

concepts in bacterial second messenger signaling and has motivated the search for previously

unknown bacterial signaling molecules such as the recently discovered cA[degrees]diA[degrees]AMP and cA[degrees]GMPAMP.

The goal of this Priority Programme is to establish the first systematic and comprehensive

strategy ever to understand all fundamental aspects of second messenger signaling in bacteria

at the molecular level. Biosynthesis, turnover and functions of cA[degrees]diA[degrees]GMP, the classics cAMP

and ppGpp, as well as newcomers such as cA[degrees]diA[degrees]AMP will be studied from molecular, cellular,

physiological, systemsA[degrees]level and ecological perspectives.


Address : Professor Dr. Regine Hengge,

Institute of Biology/Microbiology,

HumboldtA[degrees]University Berlin,

ChausseestraE-e 117,

10115 Berlin

Country :Germany

Email : regine.hengge@huA[degrees]

Tender notice number : SPP 1879

Notice type : Tender Notice

Open date : 2015-10-30

Tender documents : T28070366.pdf

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Publication:Mena Report
Date:Jul 1, 2015
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