Printer Friendly

Protein controls 'bad' cholesterol levels outside cells.

Byline: ANI

Washington, Apr 17 (ANI): A protein called PCSK9, which regulates 'bad' cholesterol in the blood, has been found to work almost exclusively outside cells, according to researchers at UT Southwestern Medical Centre.

The finding could provide clues for the development of therapies to block the protein's disruptive actions.

"The fact that it works mostly extracellularly provides more opportunities to develop different kinds of therapies," said Dr. Jay Horton, professor of internal medicine and molecular genetics and co-author of the study.

PCSK9 disrupts the activity of a key molecule called the low-density lipoprotein receptor, or LDLR, which is made and secreted in the liver.

Horton said that the new findings show that PCSK9 principally acts as a secreted protein to cause the degradation of LDL receptors by latching on to it.

"Therefore, approaches to block the protein's activity in the blood should be successful in reducing plasma cholesterol levels," he said.

In order to know if PCSK9 works inside or outside the cell, the researchers designed peptides to jam the interaction between PCSK9 and the LDL receptor.

They then added the peptides to a cultured cell medium to see if they could block the activities of PCSK9.

It was found that the peptides prevented the secreted PCSK9 from binding to the surface of the LDL receptors.

Thus Horton said that PCSK9 is likely to perform its destructive duties outside cells, in order to provide more opportunities for drug development.

"It's much easier to design inhibitors of PCSK9 function to work outside a cell than to develop a small molecule that works inside a cell," he said.

The study has been published in the online edition of the Journal of Biological Chemistry. (ANI)

Copyright 2009 Asian News International (ANI) - All Rights Reserved.

Provided by Syndigate.info an Albawaba.com company
COPYRIGHT 2009 Al Bawaba (Middle East) Ltd.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2009 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:Asian News International
Date:Apr 17, 2009
Words:300
Previous Article:Here's what women want in their men.
Next Article:Kasab retracts confession, says it was made under duress.
Topics:


Related Articles
A baby's genetic make-up can affect the health of mums-to-be.
Anger control, venting drive CV risk in blacks.
Bad cholesterol inhibits breakdown of fat in cells.
Yeast studies provide clue about controlling cholesterol levels.
Eating your way to a healthy heart.
How too much cholesterol puts life at risk.

Terms of use | Privacy policy | Copyright © 2019 Farlex, Inc. | Feedback | For webmasters