Printer Friendly

Prevalence and post-exposure prophylaxis use for needlestick injuries among health care providers in a tertiary care hospital in Kochi, India.

Introduction

Health care providers (HPs) are at a higher risk of occupational exposure to blood-borne infections through percutaneous exposure. The World Health Organization has stated that worldwide, nearly three million HPs experience such an incident (1). Around 60 pathogens can be transmitted through needlestick injuries (NSIs), of which human immunodeficiency virus (HIV) tops the list (2). NSIs have a 0.3% risk of transmitting HIV, which is the second highest (3).

Around 57% of HPs had multiple unreported NSIs in the preceding 12 months, which highlights a negligence seen among HPs (4). However, previous studies have suggested that anti-retroviral treatment (ART) reduces the risk of HIV transmission by 81% following occupational exposure (5). Limited epidemiological studies regarding the risk and circumstances of NSIs among HPs have been identified in developing countries; the use of post-exposure prophylaxis (PEP) has also been identified. The availability of similar epidemiological data will help in formulating an effective prophylactic strategy against NSIs in India. Hence, we conducted this study with the following objectives:

(a) To assess the prevalence of NSIs among HPs

(b) To assess PEP use among HPs following HIV exposure in NSIs

Materials and Methods

A cross-sectional study was conducted among HPs in Amrita Institute of Medical Sciences, Kochi, India to assess the prevalence of NSIs and PEP use among HPs following HIV exposure. This study was conducted at the Emergency Department (ED) and Infection Control Department in AIMS. This is a tertiary care institution with an average number of in-patients of 25,000 per year and employs approximately 2500 HPs. Institutional ethical committee approval was obtained prior to the commencement of the study. The study population selected was HPs comprising doctors, staff nurses, nursing assistants, health care volunteers, lab workers, students, and paramedical staff who had a documented occupational/percutaneous exposure by a needlestick. All NSIs were self-reported to the ED from January 2006 to December 2014, which were systematically recorded by the Infection Control Department. Data were classified as per the Epinet (University of Virginia) format on the basis of job category, department, device type, procedure involved, injury depth, time since initiating PEP following NSI, prescribed regimen, and follow-up status. ELISA, which confirms HIV infection, was performed immediately and at the sixth month post-exposure. On reporting to the ED, possible sources were identified and confirmed by a serology test for communicable diseases for both health care workers and the patient source.

NSIs are defined as injuries caused by an object such as hypodermic needles, IV cannulas, blood collection needles, suture needles, winged IV sets, and needles used to connect parts of IV delivery systems (6). The severity of injury was defined as a superficial (surface scratch and absence of bleeding), moderate (penetration of skin and bleeding), or deep (deep puncture or wound with or without bleeding (5)). PEP consisted of first aid, counseling, risk assessment, and short-term courses of anti-retroviral given for 30 days, along with follow-up and evaluation.

Statistical analysis

The Statistical Package for Social Science version 20 (IBM SPSS Statistics, New York; USA) was used for data analysis. Descriptive statistics were used to determine the frequency and percentage of occupational exposure. Logistic regression was used to find the association of the variables with HIV exposure. Tables and graphs are used to present the results.

Results

A total of 949 cases were reported from 2006 to 2014, and the highest incidence was noted in 2014 (15.2%) (Figure 1). Overall, there was a significant preponderance of the occurrence of NSIs among staff nurses (42.9%), followed by nursing assistants, and housekeepers with 16.9% and 9.2%, respectively. The incidence rate among doctors in our study was comparatively low (5%) (Figure 2).

The highest incidence rate of NSIs was reported in the patient room/ward (32.5%), followed by the dental clinic (18.1%) and ICU (18%). In total, 67.7% of the sustained NSIs were moderately deep, while 22.6% of injuries were superficial. The types of needles causing the NSIs were hypodermic needles (36.7%), disposable syringes (14.9%), and intravenous catheters (10%), followed by other needles (Table 1).

Most NSIs reported were during "post-procedure work-up" (64%), of which 22.4% of NSIs occurred "during manipulation after procedure" and 9.7% during recapping, while 36% occurred "during the procedure," of which 19.8% were during the use of needles (Table 2).

A total of 32 HPs of the 949 cases had received NSIs from known HIV seropositive patients, of which 62.5% of the HPs were staff nurses. In total, 84.4% of the HIV exposure cases following NSIs comprised female HPs. The mean age of HPs who received NSIs from known HIV seropositive patients were 26.6 years (Table 3). The commonest device involved was the hypodermic needle (65.6%) (Table 4). The greatest number of HIV exposure cases due to NSIs, occurred in the ICU (40.6%).

All the 28 cases were initiated on triple-drug ART, containing tenofovir 300 mg, emtricitabine 200 mg, and efavirenz 600 mg, taken orally, once daily, 2 h after food at night time for 30 days. Four of the HPs deferred due to the fear of side effects. All the HPs at risk were asked to do HIV ELISA on the day of sustaining the NSIs, followed by HIV-RNA PCR two weeks after the NSIs, and HIV ELISA during follow-up at 1 month and 6 months, respectively, and no seropositivity was reported in any of the cases.

On a logistic regression of variables with HIV exposure, the only variable significantly associated with HIV exposure was the job category of the HP. Staff nurses were proven to have 1.56 times more risk compared to the other HPs (OR=1.56, 95% CI 0.58-4.19, p=0.026).

Discussion

From a literature search, only a few hospital-based studies on the incidence of NSIs among HPs in South India could be obtained.

A total of 949 self-reported cases of NSIs from January 2006 to December 2014 were recorded, with the incidence of NSIs increasing over the years. The increased incidence of NSIs among HPs can be explained by the circumstances/procedures during which the exposure had occurred, ineffective in-service education and training on the use of person protection equipment, relative inexperience, and negligence from the HP. All HPs, after recruitment, are given initial training in infection control and waste management.

In the present study, the incidence of NSIs in a calendar year was only 105.4 HP, which could be explained by some underreporting. The main reasons for underreporting might be due to the fact that a significant proportion of HPs did not know about the existence of a PEP service and were unaware about whom to contact in the event of an occupational exposure. Other reasons include an underestimation of HIV transmission and an unwillingness to take anti-retroviral drugs, as has been noted in previous studies (7-12).

In the present study, majority of NSIs were reported by staff nurses, (42.9%), which is a similar result compared with previous studies (4, 6, 13-16). This incidence rate is high though compared with a study done by Jayanth et al. (17), where 28% of nurses had experienced NSIs. In the present study, it was revealed that students (11.4%) were found to have a higher incidence rate than doctors, probably due to their lack of awareness of occupational exposure to blood pathogens and lack of training on the use of personal protection equipment. Nursing assistants (16.3%) were also found to have a significant proportion of NSIs, probably because they were not involved in awareness programs (18-21).

In the present study, majority of NSIs occurred in patient rooms (32.5%), which was consistent with the observations made by Guo et al. (22) (38%) but differs from results of other studies, where the highest percentage of NSIs were observed in the minor operation theater and emergency operation theater (18, 23). The present study reveals that the maximum number of NSIs occurred during the "post-procedure" work-up from used needles (64%) compared to the "during procedure" work-up (36%). In the post-procedural work-up, "manipulation after use before disposal" (22.4%) had the highest incidence rate, probably because of a lack of technical preparation, distraction, and working in a hurry. In our study, NSIs during recapping had an incidence rate of 9.7%, which is in concordance with a study conducted by Yoshikawa et al. (24). Despite the existence of "universal precautions" since 1987 to prevent NSIs due to the recapping of needles, the incidence rate of NSIs due to recapping remains high (66.3%) among HPs in India (25). In total, 2.4% of the NSIs occurred due to the needle piercing the disposal container, which underlines the need for puncture-proof disposal containers. The commonest device involved was the hypodermic needle (36.7%); this fining was similar to the observations made by Radha et al. (4) (44%) (18). Studies regarding the depth of injury are rarely reported in India. In the current study, majority of pricks were moderately deep (66.3%). Superficial injuries (23.8%) were found in only 23.2%.

Of the total of 949 cases, 32 (3.47%) were found to have NSIs from HIV seropositive patients. These findings were less when compared to observations made by Kumakech et al. (26) in the UK, in which 8.93% were exposed to HIV through NSIs. This difference in the incidence rate was probably due to the higher prevalence of HIV in western countries. In the present study, 84.4% of HIV exposures to NSIs comprised female HPs, with a mean age of 26.6 [+ or -] 6.0 years, which is a similar result to that of the study conducted by McEvoy et al. (27), where 50% of the HPs were below 25 years of age. This may be due to the relative work inexperience of the staff. Staff nurses (62.5%) acquired the maximum exposure to HIV due to NSIs, which can be explained by the circumstances/procedures during which exposure would have occurred. Similar observations were made by Kumakech et al. (26) and McEvoy et al. (27), where 61% of staff nurses were exposed. In the present study, the incidence rate of NSIs among doctors was 15.6%, which is less compared to the study conducted by McEvoy et al. (27) (21%). The commonest device involved was the hypodermic needle (65.6%), for which no comparative study data could be obtained. The greatest number of HIV exposure due to NSIs occurred in the ICU (40.6%), similar to the observations made by Kumakech et al. (26), in which 46.8% occurred in medical and surgical wards. van der Maaten et al. (7) reported the highest incidence of NSIs in the obstetrics ward. Observations made in the UK and China, where physicians were not available around the clock and non- of anti-retroviral medications, had reported significant underreporting and improper PEP delivery (7, 17).

The mean duration between initiating PEP and occupational injury was 2.8 h in the current study, but it was found to be 7.6 h in a previous study (28). This may be due to the availability of an ER physician 24 h a day and 7 days a week who could counsel HPs and prescribe anti-retroviral medications.

Among the 32 HPs who received NSIs from HIV seropositive patients, 28 were initiated on triple-drug therapy, which consisted of tenofovir 300 mg, emtricitabine 200 mg, and efavirenz 600 mg taken orally, once daily, 2 h after food at night for 30 days. Four HPs deferred due to the fear of side effects. All HPs at risk were asked undergo HIV ELISA on the day of receiving the NSI, followed by HIV-RNA PCR 2 weeks after receiving the NSI, and HIV ELISA during follow-up at 1 month and 6 months, respectively, and no seropositivity was reported.

Conclusion

The present study shows the high prevalence of NSIs among HPs, particularly among staff nurses. HPs have always been known to be at risk of contracting acquired infectious diseases. In light of new emerging communicable diseases with new or unknown pathogens as causative agents, the prevention of NSIs among HPs has acquired significant value. Periodic health education campaigns should be promoted, and strict adherence to standard precautionary protocols should be made mandatory to prevent and minimize the incidence of NSIs among HPs. Periodic updates about PEP should also be made to raise awareness among HPs.

Ethics Committee Approval: Ethics committee approval was received for this study from the ethics committee of Amrita Vishwa Vidyapeetham University.

Peer-review: Externally peer-reviewed.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study has received no financial support.

References

(1.) Pruss-Ustun A, Rapiti E, Hutin Y. Estimation of the global burden of disease attributable to contaminated sharps injuries among health-care workers. Am J Ind Med 2005; 48: 48-90. [CrossRef]

(2.) Tarantola A, Abiteboul D, Rachline A. Infection risks following accidental exposure to blood or body fluids in health care workers: a review of pathogens transmitted in published cases. Am J Infect Control 2006; 34: 367-75. [CrossRef]

(3.) Bryant J, Baxter L, Hird S. Non-occupational postexposure prophylaxis for HIV: a systematic review. Health Technol Assess 2009; 13: 1-60. [CrossRef]

(4.) Radha R, Khan A. Epidemiology of needle stick injuries among the healthcare workers of rural tertiary care hospital--A cross sectional study. Nat J Community Med 2012; 3: 589-94.

(5.) Cardo DM, Culver DH, Ciesielski CA, Srivastava PU, Marcus R, Abiteboul D, et al. A case-control study of HIV seroconversion in health care workers after percutaneous exposure. N Engl J Med 1997; 337: 1485-90. [CrossRef]

(6.) Hashmi A. Prevalence of Needle-stick and Sharps Injuries among Healthcare Workers, Najran, Saudi Arabia. Epidemiology: Open Access. 2012: 117. DOI:10.4172/2161-1165.1000117. [CrossRef]

(7.) van der Maaten GC, Nyirenda M, Beadsworth MJ, Chitani A, Allain T, van Oosterhout JJ. Post exposure prophylaxis of HIV transmission after occupational injuries in Queen Elizabeth Central Hospital, Blantyre, Malawi, 2003-2008. Malawi Med J 2010; 22: 15-9. [CrossRef]

(8.) Lin C, Li L, Wu Z, Wu S, Jia M. Occupational exposure to HIV among health care providers: A Qualitative study in Yunnan, China. J Int Assoc Physicians AIDS Care (Chic) 2008; 7: 35-41.

(9.) Gumodoka B, Favot I, Berege ZA, Dolmans WM. Occupational exposure to the risk of HIV infection among health care workers in Mwanza Region, United Republic of Tanzania. Bull. Bull World Health Organization. 1997;75:133-140.

(10.) Abdel-Malek ZA, Kadekaro AL, Kavanagh RJ, Todorovic A, Koikov LN, McNulty JC, et al. Melanoma prevention strategy based on using tetrapeptide alpha-MSH analogs that protect human melanocytes from UV-induced DNA damage and cytotoxicity. FASEB J 2006; 20: 1561-3. [CrossRef]

(11.) Haiduven DJ, Simpkins SM, Phillips ES, Stevens DA. A survey of percutaneous/ mucocutaneous injury reporting in a public teaching hospital. Journal of Hosp Infect 1999; 41: 151-4. [CrossRef]

(12.) Sohn S, Eagan J, Sepkowitz KA. Safety engineered device implementation: does it introduce bias in percutaneous injury reporting? Infect Control Hosp Epidemiol 2004; 25: 532-5.

(13.) Falagas ME, Karydis I, Kostogiannou I. Percutaneous exposure incidents of the health care personnel in a newly founded tertiary hospital: a prospective study. PLoS One 2007; 2: e194.

(14.) Foley M. Update on needlestick and sharps injuries: the Needle Stick Safety and Prevention Act of 2000. Am J Nurs 2004; 104: 96. [CrossRef]

(15.) Tan L, Hawk JC, Sterling ML. Report of the Council on Scientific Affairs: preventing needlestick injuries in health care settings. Arch Intern Med 2001; 161: 929-36. [CrossRef]

(16.) Katkuri S, Begum S. Occupational Exposure to Blood and Body Fluids Among Health Care Workers in Teaching Hospital, Hyderabad, India. J Pharm Biomed Sci 2015; 5: 95-9.

(17.) Jayanth ST, Kirupakaran H, Brahmadathan KN, Gnanaraj L, Kang G. Needle stick injuries in a tertiary care hospital. Indian J Med Microbiol 2009; 27: 44-7.

(18.) Gilks CF, Wilkinson D. Reducing the risk of nosocomial HIV infection in British health worklers working overseas: role of postexposure prophylaxis. BMJ 1998; 316: 1158-60. [CrossRef]

(19.) Reis JMB, Lamounier Filho A, Rampinelli CA, Soares ECS, Prado RS, Pedroso ERP. Training-related accidents during teacher-student-assistance activities of medical students. Rev Soc Bras Med Trop 2004; 37: 405-8. [CrossRef]

(20.) Salzer HJ, Hoenigl M, Kessler HH, Stigler FL, Raggam RB, Rippel KE, et al. Lack of risk-awareness and reporting behavior towards HIV infection through needlestick injury among European medical students. Int J Hyg Environ Health 2011; 214: 407-10. [CrossRef]

(21.) Sharma GK, Gilson MM, Nathan H, Makary MA. Needlestick injuries among medical students: incidence and implications. Acad Med 2009; 84: 1815-21. [CrossRef]

(22.) Guo YL, Shiao J, Chuang YC, Huang KY. Needlestick and sharps injuries among health-care workers in Taiwan. Epidemiol Infect 1999; 122: 259-65. [CrossRef]

(23.) Souza-Borges FRF de, Ribeiro LA, Oliveira LCM. Occupational exposures to body fluids and behaviors regarding their prevention and post-exposure among medical and nursing students at a Brazilian public university. Rev Inst Med Trop 2014; 56: 157-63. [CrossRef]

(24.) Yoshikawa T, Wada K, Lee JJ, Mitsuda T, Kidouchi K, Kurosu H, et al. Incidence rate of needlestick and sharps injuries in 67 Japanese hospitals: a national surveillance study. PLoS One 2013; 8: e77524.

(25.) Muralidhar S, Singh PK, Jain RK, Malhotra M, Bala M. Needle stick injuries among health care workers in a tertiary care hospital of India. Indian J Med Res 2010; 131: 405-10.

(26.) Kumakech E, Achora S, Mbchb FB. Occupational exposure to HIV: a conflict situation for health workers. Int Nurs Rev 2011; 58: 454-62. [CrossRef]

(27.) McEvoy M, Porter K, Mortimer P, Simmons N, Shanson D. Prospective study of clinical, laboratory, and ancillary staff with accidental exposures to blood or body fluids from patients infected with HIV. Br Med J (Clin Res Ed) 1987; 294: 1595-7. [CrossRef]

(28.) Chen M, Fox E, Rogers C. Post-exposure prophylaxis for human immunodeficiency virus: knowledge and experience of junior doctors. Sex Transm Infect 2001; 77: 444-5. [CrossRef]

Arun Kumar Krishnan [1], Gireesh Kumar KS [1], Srinath Kumar TS [2], Sreekrishnan TP [1], Vijay Kumar [3], Sumi Soman [4]

[1] Department of Emergency Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, India

[2] Departmnt of Emergency Medicine, Narayana Hospital, Hosur Main Road, Bangalore, India

[3] Department of Public Health Dentistry, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, India

[4] Department of Public Health, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, India

Correspondence to: Arun Kumar Krishnan

e-mail: knowaboutarun@gmail.com

Received: 26.03.2016

Accepted: 09.05.2016

DOI: 10.5152/eajem.2016.47966
Table 1. Properties of needlestick injuries

Section-wise Distribution of        Frequency    %
Needlestick Injuries

* Patient Room/Ward                    308      32.5
* Dental Clinic                        172      18.1
* Intensive Care Unit                  171      18.0
* Procedure Room                       73       7.7
* Out Patient Clinic                   60       6.3
* Emergency Department                 49       5.2
* Other Describe                       42       4.4
* Service/Utility                      29       3.1
* Clinical Laboratories                25       2.6
* Outside Patient Room                 15       1.6
* Dialysis Unit                         5       0.5

Depth of Injury

* Superficial                          226      23.8
* Moderate                             629      66.3
* Severe                               94       9.9

Devices Associated with
Needlestick Injuries

* Hypodermic Needle                    348      36.7
* Syringe Disposable                   141      14.9
* Intravenous Catheter                 95        10
* Needle Holder/Vacuum Tube            82       8.6
* Suture Needle                        82       8.6
* Vacuette Needle                      54       5.7
* Intravenous Stylet                   39       4.1
* Needle On Intravenous Tubing         31       3.3
* Syringe, Prefilled Cartridge         28        3
* Needle, Other Vascular Catheter      17       1.8
* Butterfly Needle                     14       1.5
* Needle Described                      8       0.8
* Needle Unknown Type                   5       0.5
* Syringe, Other Type                   3       0.3
* Trocar                                2       0.2
Total                                  949      1 00

Table 2. Procedures associated with needlestick injuries

Procedure                                       Frequency     %

During the Procedure

During the use of needles                          188      19.8
Blood collection                                   44        4.6
Between steps of a multi-step procedure            25        2.6
Intravenous line insertion                         26        2.7
During surgery                                     20        2.1
Checking random blood sugar                        18        1.9
Giving injection                                   10        1.1
Cleaning                                            6        0.6
Suturing                                            4        0.4
Withdrawing a needle from rubber or other           2        0.2
  resistance

After the Procedure

Manipulation after use before disposal             213      22.4
Recapping                                          92        9.7
Device left on the floor, table, bed or other      67        7.1
  place
After disposal protruding from disposal            26        2.7
Item pierced the side of disposal container        23        2.4
While putting items into the disposal              45        4.7
  container
Waste collection                                   16        1.7
Disassembling device                               10        1.1
In preparation for reuse of reusable                3        0.3
From items left on the floor near a disposal        2        0.2
  container
Others                                            1 09      11.5
Total                                              949      100.0

Table 3. Distribution of HIV exposure among health care providers

Job Category         Number    %

Staff Nurse            20     62.5
Doctors                5      15.6
Nursing Students       3      9.4
Nursing Assistants     4      12.5
Total                  32     1 00

Table 4. Devices and HIV exposure

Type of Device        Number     %

Hypodermic needle       21     65.6
IV stylet               7      21.9
Vacuette needle         2       6.3
K wire                  1       3.1
Prefilled cartridge     1       3.1
Total                   32     100.0

Figure 1. Distribution of the incidence of needlestick injuries
by year

Year   % of NSI

2006   9.3
2007   8.7
2008   10.2
2009   10.9
2010   7.6
2011   11.5
2012   12.8
2013   13.8
2014   15.2

Note: Table made from bar graph.

Figure 2. Prevalence of needlestick injuries among health care
providers

NSI PREVALENCE IN PERCENTAGE

PARAMEDICAL              0.1
HEALTH CARE VOLUNTEERS   3.2
RESIDENT                 3.5
OTHERS                   3.9
LAB TECHNICIAN           4.5
DOCTOR                   5
HOUSE KEEPER             9.2
STUDENT                  11.4
NURSING ASSISTANT        16.3
NURSES                   42.9

Note: Table made from bar graph.
COPYRIGHT 2016 AVES
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2016 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:Original Article
Author:Krishnan, Arun Kumar; Gireesh, Kumar K.S.; Srinath, Kumar T.S.; Sreekrishnan, T.P.; Kumar, Vijay; So
Publication:Eurasian Journal of Emergency Medicine
Article Type:Report
Geographic Code:9INDI
Date:Jun 1, 2016
Words:3607
Previous Article:The predictive effect of the neutrophil-to-lymphocyte ratio (NLR) on the mortality of acute ischemic stroke and its subtypes: a retrospective...
Next Article:Effects of a standard dose of fresh frozen plasma on various elevations in the international normalized ratio.
Topics:

Terms of use | Privacy policy | Copyright © 2020 Farlex, Inc. | Feedback | For webmasters