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Prediabetes occurs in obese youths: just like in adults.

ORLANDO, FLA. -- Children and adolescents develop impaired glucose tolerance before the onset of diabetes just like adults do, and the recognition of this reversible state could prevent the onset of type 2 diabetes in some obese youth, said Dr. Sonia Caprio of Yale University, New Haven.

"We've known that adults develop impaired glucose tolerance before diabetes, but we used to know nothing about that step in children," Dr. Caprio told the annual meeting of the American College of Preventive Medicine.

She and her colleagues set out to find the role of insulin resistance and [beta]-cell function in the transition from normal to impaired glucose tolerance to type 2 diabetes in youth.

They studied 28 obese children, half with impaired glucose tolerance and half with normal glucose tolerance.

Results of the Oral Glucose Tolerance Test showed that the impaired glucose tolerance group had significantly higher 2-hour glucose, fasting insulin, and 2-hour insulin levels, and significantly lower adipopectic levels.

The group with impaired glucose tolerance also had a significantly higher proportion of intramyocellular lipid content, as well as significantly lower levels of insulin-stimulated glucose metabolism, than those with normal glucose tolerance.

These findings suggest that prediabetes youth have the same insulin tolerance issues as do adults, and that clinicians need to watch for signs of impaired glucose tolerance in obese youngsters.

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Author:Perlstein, Steve
Publication:Pediatric News
Geographic Code:1USA
Date:Aug 1, 2004
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