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Post traumatic borderline tuberculoid leprosy over knee in an Indian male.

Case History

A 23-year-old Indian male presented with a 6-month history of asymptomatic, skin lesions over the left knee. There was a history of traumatic injury at the same site. While playing football in his village 2 years ago he fell down on the ground and abraded his left knee. Such injuries are routine while playing football, and as it was a minor one no treatment was sought. Cutaneous examination showed multiple shiny, flat-topped, mildly erythematous, discrete and grouped papular lesions and annular plaques with central atrophy, varying in size from 2-8 mm in diameter, distributed in a linear fashion on the medial aspect of the left knee, along with an ill-defined, hypopigmented oval patch in the central part on medial aspect of the knee joint (Figure 1).

On sensory testing hypoaesthesia to temperature and pinprick sensation was observed in the plaques and on the hypopigmented patch. There were no other skin lesions, nerve thickening or systemic complaints. There was no hepatosplenomegaly or abnormal systemic finding. The haematological investigations, X-ray chest, high resolution CT thorax, serum calcium and serum ACE levels were normal. Mantoux test was 10 mm X 10 mm. Staining and culture for fungus was negative. Slit smear examination from the skin lesions and routine sites including both the ear lobes did not reveal any acid-fast bacilli.

Histology of skin biopsy revealed multiple non-caseating lymphohistiocytic granulomas in the upper and mid-dermis along with Langhan's giant cells (Figure 2), at places linear in distribution along the nerves (Figure 3), which suggested borderline tuberculoid leprosy.

The Ziehl-Neelsen stain of the tissue did not reveal any acid-fast bacilli. The patient was diagnosed as a case of borderline tuberculoid leprosy and put on WHO PB-MDT (Pauci Bacillary Multidrug Therapy) with tablet dapsone 100 mg. daily and capsule rifampicin 600 mg. monthly. The lesions regressed significantly after 6 months of treatment, corroborating the diagnosis.

[FIGURE 1 OMITTED]

Discussion

The asymptomatic lesions, hypoaesthesia in the plaques and in the hypopigmented patch raised the suspicion of leprosy. However, the linearly distributed papules and plaques as observed here were unusual. Histoid leprosy, cutaneous sarcoidosis, granuloma annulare and lupus vulgaris were considered in the differential diagnosis clinically. The histopathological findings from the plaque and the papules were of borderline tuberculoid leprosy and various investigations mentioned earlier ruled out the other clinical possibilities. There have been scant reports of leprosy developing at the site of injury, (1,2) tattooing and vaccination. (3-7) The period between entry of the organism and development of leprosy lesion is known to vary from a few years to a few decades. (3) The observation of pseudo-isomorphic phenomenon of Koebner was reported for the first time in leprosy in 2009.8 The linear distribution of the lesions over a frequently traumatised site in this case is also suggestive of inoculation leprosy as well as koebnerization. However, it is not easy to pinpoint the mode of acquisition of infection in this particular case, but circumstantial evidence points towards inoculation leprosy. Minor traumatic injuries on the extremities are common while engaged in sports and work activities such as farming, are often left untreated and are usually forgotten. It is difficult to conclude which particular injury or injuries were responsible for bacillary inoculation. In this highly endemic region, the wound site could have been exposed to M. leprae following the injury. There is also a possibility of bacilli being drawn to this site, after entry from the respiratory tract, as has been proposed earlier in a report of similar inoculation in a leprosy hospital. (1) Several factors, including the depth of the inoculum and its volume along with genetic factors and environmental micro-organisms could modulate the development of inoculation leprosy. (9) This case validates the author's earlier suggestion, that if one or two leprosy lesions are found in exposed and trauma prone and/or abraded parts of the body, especially extremities, a possibility of inoculation leprosy should be entertained, and that leprosy is inoculable. (2,7)

[FIGURE 2 OMITTED]

[FIGURE 3 OMITTED]

The reports of demonstration of M. leprae in the epidermis, their transepidermal elimination and presence in epidermal washings in multibacillary patients, point towards the possible role of skin in spread of leprosy. (10-12) This particular case and the earlier referenced publications highlight the importance of skin in leprosy transmission.

References

(1) Brandsma JW, Yoder L, Macdonald M. Leprosy acquired by inoculation from a knee injury. LeprRev, 2005; 76: 175-179.

(2) Ghorpade A. Post traumatic tuberculoid leprosy after injury with a glass bangle. Lepr Rev, 2009; 80: 215-218.

(3) Ghorpade A. Inoculation (tattoo) leprosy: a report of 31 cases. J Eur Acad Dermatol Venereol, 2002; 16: 494-499.

(4) Ghorpade A. Ornamental tattoos and skin lesions. Int J Dermatol, 2009; 48: 11-13.

(5) Sehgal VN, Rege VL, Vediraj SN. Inoculation leprosy subsequent to smallpox vaccination. Dermatologica, 1970; 141: 393-396.

(6) Ghorpade A. Inoculation indeterminate leprosy on smallpox vaccination scar. Lepr Rev, 2007; 78: 398-400.

(7) Ghorpade A. Inoculable leprosy. Int J Dermatol, 2009; 48: 1267-1268.

(8) Ghorpade A. Molluscoid skin lesions in histoid leprosy with pseudo-isomorphic phenomenon of koebner. Int J Dermatol, 2009; 47: 1278-1280.

(9) Naafs B, Silva E, Vilani-Moreno F et al. Factors influencing the development of leprosy: an overview. Int J Lepr Other Mycobact Dis, 2001; 69: 26-33.

(10) Satapathy J, Kar BR, Job CK. Presence of Mycobacterium leprae in the epidermal cells of lepromatous skin and its significance. Indian J Dermatol Venereol Leprol, 2005; 71: 267-270.

(11) Ghorpade AK. Transepidermal elimination of Mycobacterium leprae in histoid leprosy: a case report suggesting possible participation of skin in leprosy transmission. Indian J Dermatol Venereol Leprol, 2011; 77: 59-61.

(12) Job CK, Jayakumar J, Kearny M et al. Transmission of leprosy: a study of skin and nasal secretions of household contacts of leprosy patients using PCR. Am J Trop Med Hyg, 2008; 78: 518-521.

ASHOK GHORPADE

Department of Dermatology, Venereology & Leprosy, JLN Hospital & Research Centre, Bhilai Steel Plant, Bhilai, Chhattisgarh state, India

Accepted for publication 1 October 2013

Correspondence to: Ashok Ghorpade, BK D-18, Sector 9, Bhilai, Chhattisgarh-490006, India (Tel: + 91 788 2227856; Fax: + 91 788 2241926; e-mail draghorpade@yahoo.com)
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Title Annotation:CASE REPORT
Author:Ghorpade, Ashok
Publication:Leprosy Review
Date:Sep 1, 2013
Words:1015
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