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Portal vein ligation and in situ liver splitting in metastatic liver cancer.

INTRODUCTION

One of the most important limiting factors for major liver resection is insufficient remnant liver volume. Depending on preoperative liver function, a liver remnant of 25%-40% is considered sufficient to avoid postoperative liver failure (1, 2). Portal vein embolization (PVE), chemotherapy, local ablation, and surgical portal vein ligation have been developed to induce liver tissue hypertrophy before major liver resection. In situ liver splitting and portal vein ligation (PVL) have been developed to induce rapid and effective hepatic hypertrophy as an alternative to these methods (3). In this approach, at the first stage, the hepatic vein, artery, and hepatic canal are preserved while PVL is performed; then, the liver parenchyma is split. At the second stage, the hepatic artery, vein, and hepatic canals are tied and the approach is completed with hepatectomy. This technique has been well accepted and used with good outcomes worldwide. Herein, we present a case where we performed PVL combined with in situ liver splitting.

CASE PRESENTATION

A 37-year-old male patient with a diagnosis of sigmoid adenocarcinoma and liver metastasis (cT4N1M1) underwent anterior resection in December 2012 because of an obstructing sigmoid tumor; he also underwent palliative chemotherapy. After the chemotherapy, abdominal computed tomography (CT) revealed that there was no regression over the metastatic lesions localized in the right lobe of the liver; thus, a right hepatectomy procedure was planned. A written informed consent was obtained from the patient. Abdominal CT revealed a lesion, 50 mm in diameter, localized between segments 5 to 8 of liver on the bifurcation of the anteroposterior segmental branch of the right portal vein (Figure 1). According to abdominal CT volumetric evaluation during the preoperative period, the volume of the left liver remnant was less than 25% and would not be sufficient for liver function.

In the first stage, perioperative ultrasound was performed to evaluate the left lobe. Only a subcapsular millimetric nodule was detected. The right portal vein was transected with a vascular staple; the right hepatic artery, vein, and right hepatic canal were saved (Figure 2, 3), and the parenchymal dissection of the right liver lobe was performed with an ultrasonic dissector and isolated with a sterile plastic bag (Figure 4). Additionally, the subcapsular millimetric nodule localized to the left lobe was excised. At the end of the first stage of this approach, a drain was placed in the subhepatic region before closure of the abdomen. The total operation time was 210 minutes and the total amount of blood loss was 1000 ml.

On postoperative days (PODs) 2 and 6 of the first operation, it was revealed by abdominal CT that the volume of the left lobe was hypertrophied by more than 25% (Figure 5). It was seen that the left lobe passed the midline, extending toward the spleen (Figure 6). For the second stage, the right hepatic vein was transected with a vascular staple, and the right hepatic artery and right hepatic canal, which had been saved during the first stage, were tied with 2/0 silk sutures. Right hepatectomy was completed with removal of the previously split right liver parenchyma. The total operation time was 60 minutes, and the total blood loss was 50 mL After the second stage of surgery, the patient's INR, total bilirubin, and direct bilirubin levels were 1.61, 3.7 mg/dl, and 2.82 mg/dL, respectively. His AST and ALT levels were two times higher than the normal range. However, before his discharge from the hospital, the patient's liver function tests were normal. The patient was discharged on POD 11 uneventfully. On POD 20, abdominal CT revealed that the left lobe was hypertrophied by passing through the midline up to the midclavicular line (Figure 7). Histopathological examination revealed a colonic-type metastatic adenocarcinoma on the right lobe of the liver at segment four. After a follow-up of two years, the patient has no recurrence. A recent PET-CT scan is shown in Figure 8.

DISCUSSION

The only curative treatment option for primary or metastatic liver cancers is surgical excision. However, in some patients with large tumors or with small tumors close to central main structures, the functional remnant liver volume after radical resection may be too small to maintain normal liver function. At least 25%-40% of the liver volume should be left after surgery to maintain normal liver function (3). Schnitzbauer et al. (3) described a two-stage technique that enhanced liver hypertrophy in a short period of time. This technique is known as associating liver partition and portal vein ligation (ALPPS).

Portal vein ligation, chemotherapy, local ablation, and surgical PVL are other methods used to increase the volume of the liver before resection. In an article published by Liu and Zhu (4), it was demonstrated that the liver underwent hypertrophy by about 10%-46% within 2-8 weeks after PVE. In another study, it was shown that the liver was hypertrophied by 38% within eight weeks after PVL (5). However, tumor progression, insufficient hypertrophy, and invasions of tumors to the right portal vein and precluding PVE are some disadvantages of these techniques. Additionally, in the case of small metastatic lesions on the left liver lobe, the blood supply to these lesions also increases with radiologic right PVE. The ALPPS approach induces a median hypertrophy of 74% within nine days (3). One of the benefits of ALPPS is the ability to remove tumors earlier than radiologic PVE. According to some authors, a disadvantage of ALPPS is the persistence of the right liver parenchyma within the plastic bag; if, for some reason, the second stage of this procedure cannot be performed, further surgery is required to remove this plastic bag.

In our case, it was seen that the liver was hypertrophied on the 6th day after the first stage; right hepatectomy was then performed for the second stage. Liver function tests were slightly elevated in the early days of postoperative evaluation, but no liver failure occurred. It was observed that starting on the 10th day after the first operation, the patient's liver function tests were normal.

The morbidity after major liver resections is 20%-50%, depending on the general status of the patient during the operation, the presence of an underlying disease, and the size of the resection (6, 7). In the literature, biliary fistula, sepsis, and infection have been described as the major complications of ALPPS during the postoperative period (3).

Between 2011 and 2014, 320 ALPPS operations have been performed in 55 different centers worldwide (8). The age of the patient, type of tumor, timing of the operation during the first stage, and intraoperative blood transfusion are factors affecting the mortality. Patients over 60 years of age who are treated with ALPPS and those who undergo operations due to gallbladder carcinoma or cholangiocarcinoma show higher mortality rates (8).

The disadvantage of ALPPS that we encountered in our case was higher intraoperative blood loss compared to standard right hepatectomy.

CONCLUSION

Portal vein ligation combined with in situ splitting has been used to obtain rapid and adequate liver hypertrophy. This new approach could increase the number of curative resections in patients with locally advanced and primary or metastatic liver tumors.

Informed Consent: Written informed consent was obtained from patient who participated in this study.

Peer-review: Externally peer-reviewed.

Author Contributions: Concept - B.B., I.H., I.M.; Design - A.A., B.B., D.A.; Supervision - I.H., B.B., A.A.; Resource - S.F., S.U., I.A.B.; Materials - A.A., B.B., S.B.; Data Collection and/or Processing - A.A., S.B., IA.B.; Analysis and/or Interpretation - D.A., A.A., B.B.; Literature Search - S.F., S.U., A.A.; Writing Manuscript - A.A., DA, B.B.; Critical Reviews - B.B., I.H., I.M.

Conflict of Interest: The authors have no conflicts of interest to declare.

Financial Disclosure: The authors declared that this study has received no financial support.

REFERENCES

(1.) Tucker ON, Heaton N. The 'small for size' liver syndrome. Curr Opin Crit Care 2005; 11: 150-155. [CrossRef ]

(2.) Tanaka K, Shimada H, Matsuo K, Ueda M, Endo I, Togo S. Remnant liver regeneration after two-stage hepatectomy for multiple bilobar colorectal metastases. Eur J Surg Oncol 2007; 33: 329-335. [CrossRef]

(3.) Schnitzbauer AA, Lang SA, Goessmann H, Nadalin S, Baumgart J, Farkas SA, et al. Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings. Ann Surg 2012; 255: 405-414. [CrossRef]

(4.) H. Liu, S. Zhu. Present status and future perspectives of preoperative portal vein embolization. Am J Surg 2009; 197: 686-690. [CrossRef]

(5.) Aussilhou B, Lesurtel M, Sauvanet A, Farges O, Dokmak S, Goasguenet N, et al. Right portal vein ligation is as efficient as portal vein embolization to induce hypertrophy of the left liver remnant. J Gastrointest Surg 2008; 12: 297-303. [CrossRef]

(6.) Sgourakis G, Sotiropoulos GC, Bockhorn M, Fuzas I, Radtke A, Molmenti EP, et al. Major liver resections for primary liver malignancies in the elderly. Acta Chir Belg 2009; 109: 340-344. [CrossRef]

(7.) Lang H, Sotiropoulos GC, Fruhauf NR, Domland M, Paul A, Kind EM, et al. Extended hepatectomy for intrahepatic cholangiocellular carcinoma (ICC): when is it worthwhile? Single center experience with 27 resections in 50 patients over a 5-year period. Ann Surg 2005; 241: 134-143.

(8.) Schadde E, Raptis DA, Schnitzbauer AA, Ardiles V, Tschuor C, Lesurtel M, et al. Prediction of mortality after ALPPS stage-1: an analysis of 320 patients from the international ALPPS Registry. Ann Surg 2015; 262: 780-786. [CrossRef]

Afag Aghayeva (1), Bilgi Baca (1), Deniz Atasoy (1) [iD], Sina Ferahman (2), Sezgin Uludag (2), Ismail Ahmet Bilgin (3), Sonay Beyatli (4), Ismail Mihmanli (5), Ismail Hamzaoglu (3)

ORCID ID of the author:

D.A. 0000-0002-5703-4549.

Cite this paper as:

Aghayeva A, Baca B, Atasoy D, Ferahman S, Uludag S, Bilgin IA, et al. Portal vein ligation and in situ liver splitting in metastatic liver cancer. Turk J Surg 2018; 34(4): 327-330.

(1) Department of General Surgery, Acibadem University School of Medicine Atakent Hospital, Istanbul, Turkey

(2) Department of General Surgery, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey

(3) Department of General Surgery, Acibadem University School of Medicine Maslak Hospital, Istanbul, Turkey

(4) Student of Acibadem University School of Medicine, Istanbul, Turkey

(5) Department of Radiology, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey

This study was presented at the 19th National Surgical Congress, 16-20 April 2014, Antalya, Turkey.

Corresponding Author

Afag Aghayeva

e-mail: aghayevaa@gmail.com

Received: 31.01.2016

Accepted: 19.04.2016

[c]Copyright 2018 by Turkish Surgical Association

Available online at turkjsurg.com

DOI: 10.5152/turkjsurg.2017.3507
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Title Annotation:Case Report
Author:Aghayeva, Afag; Baca, Bilgi; Atasoy, Deniz; Ferahman, Sina; Uludag, Sezgin; Bilgin, Ismail Ahmet; Be
Publication:Turkish Journal of Surgery
Article Type:Case study
Date:Dec 1, 2018
Words:1772
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