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Plant polyphenol may help improve wound healing.

OSAKA, Japan, April 21, 2016 -- Scientists here have found that a plant-based polyphenol promotes the migration of mesenchymal stem cells (MSCs) in blood circulation and accumulates them in damaged tissues to improve wound healing, scientists have found.

The results could be used for stem cell treatments for cutaneous disorders associated with various damage and lesions.

A group of Osaka University researchers showed that cinnamtannin B-1, or vegetable-based polyphenol, promotes the migration of mesenchymal stem cells (MSCs) in blood circulation and accumulates them in damaged tissues to improve wound healing.

Cinnamtannin B-l likely increases mobilization through the activation of enzymes surrounding MSC membranes and that the unique structure of cinnamtannin B-l played an important role in that mechanism.

Flow cytometry analysis using mouse blood showed that MSCs were released from bone marrow to the blood in cinnamtannin B-1-administered mice.

In vivo imaging analysis showed that MSCs migrate to wound treated with cinnamtannin B-l. It was also observed through experimentation that cinnamtannin B-l enhanced wound healing.

Cinnamtannin B-l migrated MSCs surrounding bone marrow and blood vessels to the blood and accumulated them on the wound site to enhance wound healing.

Experiments using enzyme inhibitors showed the possibility that cinnamtannin B-l enhanced mobilization through by activating enzymes such as PI3 kinase near the cell membrane.

Evaluating the activity of the molecular structure of cinnamtannin B-l by structural unit found that a dimeric structure in which two cate-chin are bound at a specific site is important for promoting the mobilization of MSC.

Cinnamtannin B-l accumulated MSC to damaged tissues to improve wound healing. These results will be used for stem cell treatments for cutaneous disorders associated with skin damage and lesions.

Citation: Kosuke Fujita et al., "Cinnamtannin B-l Promotes Migration of mesenchymal stem cells and Accelerates Wound Healing in Mice," PLOS ONE, 2015; 10(12): e0144166 DOI: 10.1371/journal.pone.0144166

Abstract: http://goo.gl/Fj8LMN

Contact: Akito Maeda, amaeda@uic.osaka-u.ac.jp

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Title Annotation:Basic Research
Publication:Stem Cell Research News
Date:Apr 25, 2016
Words:321
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