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Physiological Responses to Heat Acclimation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Introduction

Hot and humid ambient environments affect the human physiological response to physical activity (No and Kwak, 2016; Tucker et al., 2004), and exercise-induced increases in core temperature ([T.sub.C]) and increased ambient temperature result in premature fatigue and loss of athletic performance (Al-Nawaiseh et al., 2013). Muscle and skin blood flow (Sawka et al., 2011), aerobic capacity (Tucker et al., 2004), early onset of anaerobic threshold (Tyka et al., 2009), stimulation and accumulation of stress hormones (Jones et al., 2010), increased anaerobic glycolysis, increased use of intramuscular glycogen and lactate accumulation (Tan et al., 2018), are all factors associated with increased body temperature during exercise. However, competitive athletes compete in a variety of environmental conditions, which emphasizes the importance of reducing the potential adverse effects of a hot environment on athletic performance (Al-Nawaiseh et al., 2013). Heat acclimatization (HA) has been undertaken by endurance athletes to enhance tolerance and exercise performance in hot conditions (Guy et al., 2016; Periard et al., 2015a). Generally, HA has been undertaken at sub-maximal intensities during exposure to elevated temperature and/or humidity (Taylor, 2014; Tyler et al., 2016). Some of these studies have reported beneficial responses, such as decreases in heart rate (HR), [T.sub.C] and skin temperatures ([T.sub.S]) (Brade et al., 2013).

Alterations in critical physiological parameters such as increased plasma volume (PV), reduced exercise HR ([HR.sub.E]) (Kelly et al., 2016; Sawka et al., 2011), lower resting and exercise [T.sub.C] (Sawka et al., 2011; Tyler et al., 2016), and improved maximal cardiac output (Sawka et al., 1985; Shvartz et al., 1977), can all lead to increased performance (Guy et al., 2016) via short and medium duration HA programs. These adaptations could be beneficial for consequent performance in the heat, as well as in the cold, where possible fluid loss may be considerable (Corbett et al., 2014). The apparent dose-response to HA proposes that 15 days or more is required to optimize performance (Guy et al., 2015). Nevertheless, PV, HR and [T.sub.C] adjustments can take place as quickly as four days, and sustained thermal adaptation needs to be maintained by regular exertional exposure to hot climates (Weller et al., 2007).

Numerous elite sporting competitions are programmed in geographical locations that involve exposure to hot and humid environments, such as the 2020 Tokyo Olympics and 2022 Qatar World Cup. Hence, it is essential that athletes should be readied for such competitions, especially those who live and exercise in cold environments or are unaccustomed to heat stress (Milne and Shaw, 2008).

A previous meta-analysis on HA efficacy was conducted (Tyler et al., 2016), but only included investigations up until February 2016 and also included non-randomized, controlled trials. Additional randomized controlled trials (RCTs) have since been published, and this argues in favor of carrying out an updated meta-analysis. This update includes data pooling for several outcomes that were previously not carried out because of insufficient outcome data. The aim of this meta-analysis was to update previous pooled analyses, using only level 1 (RCT) evidence, on outcome measures relating to thermoregulatory adaptations attributed to HA with athletic performance in RCTs.

Methods

Search strategy

This systematic review and meta-analysis has been rep orte d using the PRISMA guid eline s (Liberati et al., 2009). Accordingly, using a PubMed search strategy (1966 to Nov 1, 2018), we identified relevant articles by the following keywords: "acclimation", "acclimatization", "heat", "acclimation and performance", "temperature", "exercise training in heat". Then, after the initial screening, the references of all studies based on the inclusion and exclusion criteria were examined to find additional studies.

Study selection

Two reviewers separately looked at the titles and read the abstracts and filtered relevant articles to be included. The four-phase (identifying, screening, qualification and inclusion) method identified were used in the PRISMA report to diminish the number of primary search results.

Inclusion/exclusion criteria

Study design: full text articles of controlled trials and RCTs of heat exercise training of natural and artificial HA, excluding review articles, conference abstracts and study protocols.

Comparison intervention: study protocols that used heat training (HOT) with thermo-neutral training (NEUTRAL), in a pre-post design, excluding the studies on acute interventions (e.g., single-session interventions) and also water immersion interventions.

Population: Men and women (age [greater than or equal to] 18 years) who identified as triathletes, runners, endurance athletes, cyclists or team sport athletes from both elite and sub elite competitive levels.

Publications: English language manuscripts published in specialised English journals.

Outcome measures

The outcome measurements of this meta-analysis were;

Time trial (TT) performance (in seconds): in included studies TT performance were measured with the test of maximal leg cycle exercise test (time to reach exhaustion), 5 km TT performance, 20-km cycling, and running 3 km TT on a motorized treadmill.

Maximum oxygen uptake (V[O.sub.2max] in ml/kg/min), Exercise ([HR.sub.E]), time trials ([HR.sub.TT]) and maximal heart rate ([HR.sub.M]).

Core ([T.sub.C]) and mean skin temperature ([T.sub.S]): in included studies [T.sub.C] was measured in the rectal (Guy et al., 2016; Lorenzo et al., 2010; Sunderland et al., 2008; Willmott et al., 2016), gastrointestinal (Chalmers et al., 2016; Petersen et al., 2010; Schmit et al., 2018), and oesophageal (Nielsen et al., 1993) sites. In addition, end exercise values (Lorenzo et al., 2010; Nielsen et al., 1993) and also delta temperature from pre-post values (Chalmers et al., 2016; Guy et al., 2016; Petersen et al., 2010; Schmit et al., 2018; Willmott et al., 2016) were used for T.sub.C and T.sub.S in included studies.

Thermal comfort ([T.sub.Comf]): in included studies [T.sub.Comf] was determined according to the 5-point scale, 8-point scale or a 10-point scale.

Plasma volume (PV in percent): change in PV (%) was estimated using the method of Dill and Costill 1974 or PV was calculated from body mass by the equation of Sawka et al 1992.

Blood lactate (mmol.L).

Rate of perceived exertion (RPE): in included studies RPE was measured using the Borg and Kaijser 2006 scales.

Statistical analysis

For all included studies, we summarized the effect size for any outcome by measuring the mean difference between the heat and neutral condition from before and after the intervention. If multiple articles were published from the same dataset then we checked the data in order to avoid using the same results for the same outcome measure on more than one occasion. Results were analyzed by weighted mean difference (MD), if the measurement method or reporting was identical. For outcomes using different measurement or reporting techniques a standardized mean difference (SMD) was used. All analyses were conducted using Review Manager 5.3 (The Nordic Cochrane Centre, Copenhagen, Denmark). Extracted outcome data employed were change in the mean [+ or -] SD. In studies that reported SE data, these were converted to SD. A random-effects inverse variance was employed. When a standardized mean difference (SMD) was used the guideline for commentary was used (Cohen, 1988), with 0.2 described as small, 0.5 medium and 0.8 as large. Where an article contained a control group and more than one HA group, we separately labelled each HA groups and adjusted the sample size of the control group according to the number of HA groups. We presented meta-analysis using forest plots and applied a 5% level of significance to describe the significance of results.

Heterogeneity: To evaluate the heterogeneity among the studies, the I2 statistic was employed, with values > 50% showing substantial heterogeneity (Higgins et al., 2003). The risk of publication bias was assessed using the Egger plot (Egger et al., 1997). Any analysis of heterogeneity depends on the number of trials included in a metaanalysis, which is generally small, and this limits the statistical power of the test. We therefore based evidence of asymmetry on P<0.1, and we present intercepts with 90% confidence intervals.

Study quality: Study quality and reporting was assessed using the validated TESTEX scale (Table 1) (Smart et al., 2015). This is a validated 15-point scale which evaluates quality of the study (5 points maximum) and reporting (10 points maximum). A study with a TESETX quality score of less than 10 was deemed of low quality.

Results

Study characteristics

Figure 1 displays the selection process employed to include manuscripts in our meta-analysis. Of 617 possibly associated articles reclaimed from the search, 113 were animal studies and a further 489 were excluded by title or abstract, leaving 19 full text articles. A further 4 were excluded as duplicate studies, two more were excluded as they used immersion water protocol and 2 used an acute protocol, leaving 11 studies for the meta-analysis.

The characteristics of the included articles are shown in Table 2. The eleven included studies had a total of 215 subjects, 195 (91%) males and 20 (9%) females. There were 123 (57%) subjects in heat group and 92 (43%) in the non-heat group. The mean age of all subjects was 26.09 [+ or -] 0.09 years. All included articles were RCTs promulgated since 1993. Studies were performed in the United State (1), France (1), Taiwan (1), Denmark (2), England (2), and in Australia (4). The intervention period for studies ranged from 4-14 days and the mean length of each session was 59 min (range 27-90 min). The HOT protocols frequency were 4-14 days (1-2 session per day), 27-90 min in each session at 30% V[O.sub.2] to 100% [HR.sub.max]. The reviewed full-text studies were excluded from the analysis with 3 reasons (non-randomized control trial study, used an acute protocol, inadequate participants population).

Outcome measures

Change in Time Trial (TT) performance: The change in exercise TT performance following HA is depicted in Figure 3. Four studies reported the effects of HA on TT performance, nevertheless, six data sets were investigated owing to subgroups in the studies of Schmit et al. (2018) and Willmott et al. (2016). The SMD in the TT performance significantly changed after HA (SMD, 0.50; 95% CI, 0.03 to 0.97; p = 0.04).

Change in V[O.sub.2max]: The change in V[O.sub.2max] (ml.[kg.sup.-1]. [min.sup.-1]) following HA is displayed in Figure 4. Four studies evaluated the V[O.sub.2max]. HA did not have a significant effect on V[O.sub.2max] (MD, 2.51 ml.[kg.sup.-1] x [min.sup.-1]; 95% CI, -1.36 to 6.37; p = 0.20).

Change in Exercise Heart Rate ([HR.sub.E]): Five studies reported the effects of HA on [HR.sub.E], however, seven intervention groups were evaluated owing to subgroups in the studies of Chalmers and Willmott. The MD in the [HR.sub.E] did not significantly change after HA (MD, -1 beats/min; 95% CI, -2 to 1; p = 0.15) (Figure 5).

Changes in Time Trial Heart Rate ([HR.sub.TT]): The effects of HA on [HR.sub.TT] was reported in three studies, nonetheless, owing to subgroups in the studies of Schmit and Willmott, five intervention groups were analyzed. Figure 6 reveals the SMD change in [HR.sub.TT] with HA. The change in [HR.sub.TT] was significantly higher in the HA groups (SMD, 1 beats/min; 95% CI, 1 to 2; p = 0.007).

Changes in Maximum Heart Rate ([HR.sub.M]): The effects of HA on [HR.sub.M] was reported in three studies, nonetheless, owing to subgroups in the studies, four data collections were reported. Figure 7 displays the MD changes in [HR.sub.M] with HA. The [HR.sub.M] decreased significantly after HA (MD, -7 beats/min; 95% CI, -13 to -1; p = 0.03).

Changes in Core Temperature ([T.sub.C]) and mean skin temperature ([T.sub.S]): The effects of HA on [T.sub.C] was reported in eight studies, however, owing to subgroups in the studies, 11 data collections were reported. On the other hand, the mean [T.sub.S] was reported in five studies. Figure 8 displays the MD changes in [T.sub.C] (A) and mean [T.sub.S] (B) with HA, respectively. Neither the changes of [T.sub.C] nor the changes of mean T.sub.S were significant. (MD, -0.05[degrees]C; 95% CI, -0.15 to 0.04; p = 0.28; MD, -0.31[degrees]C; 95% CI, -0.68 to 0.06; p = 0.10 for [T.sub.C] and mean [T.sub.S] respectively).

Changes in Plasma Volume (PV): Six studies reported the effects of HA on PV, nevertheless, eight data collections were evaluated owing to subgroups in the studies. Figure 9 illustrates the SMD in the PV. PV did not change significantly after HA (SMD, 0.64 percent; 95% CI, -0.18 to 1.45; p = 0.13).

Change in Blood Lactate: Four studies reported the effects of HA on blood lactate, nevertheless, five data sets were evaluated owing to subgroups in one of the studies. Figure 10 illustrates the MD in blood lactate which did not change significantly after HA (MD, 0.37 mmol.L; 95% CI, -0.22 to 0.97; p = 0.22).

Changes in [T.sub.Comf]: The effects of HA on [T.sub.Comf] was reported in five studies, however, owing to subgroups in the studies, six data collections were reported. The change in [T.sub.Comf] was less than 0.2 of a unit and is therefore not reported graphically as it is not physiologically meaningful.

Changes in RPE: The effects of HA on the RPE was reported in six studies, however, owing to subgroups in the studies, nine data collections were reported. The change in RPE was less than 0.5 of a unit and is therefore not presented graphically as it is not physiologically meaningful.

Heterogeneity: For the analyses of TT performance, [HR.sub.TT], [HR.sub.M] and [T.sub.Comf] (all 0%) and also for the RPE analysis (6%) heterogeneity was low.

Study Quality: Median TESTEX score was 10 (see Table 1). Allocation concealment and assessor blinding were not performed in any of the included studies. Only two studies performed intention to treat analyses. Only two studies adjusted the relative training intensity.

Discussion

This meta-analysis aimed to update previous pooled analyses, using only level 1 RCT evidence on outcome measures relating to thermoregulatory adaptations attributed to HA during athletic performance. The results reveal that HA significantly improved TT performance, [HR.sub.TT], [HR.sub.M]. The change in RPE and [T.sub.Comf] were too small to be meaningful. However, there was no evidence of improvement in V[O.sub.2max], [HR.sub.E], [T.sub.C], [T.sub.S], PV and blood lactate concentration after HA. The relatively low levels of heterogeneity indicate data pooling was justified in the analyses.

TT Performance

Our result indicates HA had a significant effect on exercise TT performance. This finding is consistent with the results of Tyler et al. 2016, who reported HA had a moderately beneficial impact on exercise performance in the heat; nevertheless, they stated longer regimens (14 days) were more efficient than shorter programs (< 7 days). Another study has also suggested the extent of enhancements are dependent upon the training situation, exercise intensity and duration, environmental conditions and period of the HA protocol utilized (Periard et al., 2015b; Sunderland et al., 2008). Other work has shown that, by diminishing physiological pressure and reducing various other potential fatigue mechanisms, HA mediates improved performance (Nybo et al., 2011). The magnitude of HA advantage depends on the heat exposure frequency, with the highest effect sizes after long-term HA regimens, however both short-term and medium-term HA (8-14 days) shows moderate benefits (Tyler et al., 2016). Our sub-analysis also illustrates that the two studies with 5 days HA produced the highest alteration in TT performance (Chen et al., 2013; Schmit et al., 2018). Whilst there is no information to demonstrate the number of heat exposures required to improve performance, older work suggests full acclimatization may take up to one month (Horvath and Shelley, 1946).

V[O.sub.2max] and PV

Our results revealed no significant change in V[O.sub.2max] and PV following HA. A recent meta-analysis reported that HA had a moderate impact on reducing V[O.sub.2max] during steady-state, fixed-intensity exercise (Tyler et al., 2016). Blood volume adaptations in response to climate manipulation were first published via Barcroft et al. (1922). A full description of the hematologic adjustments correlated with heat exposure have been published in subsequent works thereafter, suggesting that alterations in PV occur quite quickly and induce a transient reduction in hemoglobin and hematocrit, and sometimes the concentration of plasma proteins (Bazett et al., 1940). It has been suggested that an increase in V[O.sub.2max] could be mediated by PV expansion (Periard et al., 2015a), increased myocardial efficiency, and enhanced ventricular compliance (Bhella et al., 2014; Opondo et al., 2015), which would provide larger end-diastolic volume. In our study, neither myocardial efficiency nor ventricular compliance was investigated. Kanstrup and Ekblom (1984) stated that PV expansion was counter-productive in that it enhanced maximal cardiac output 8% but declined hemoglobin concentration by 8%; therefore V[O.sub.2max] remained unaltered. Furthermore, our findings indicate that the size of PV increase is influenced by the number of days of HA, the hydration state when calculated, [T.sub.S] and whether the person is resting or exercising (Harrison, 1985; Kenefick et al., 2014; Sawka et al., 1983).

[HR.sub.E], [HR.sub.M] and [HR.sub.TT]

The changes in [HR.sub.M] and [HR.sub.TT] after HA were statistically significant in the HA groups, but [HR.sub.E] was unchanged. The mechanisms of adaptation in [HR.sub.E] are various and complicated, however PV changes induced via exercise, may account for most of the exercise-induced hypervolemia up to 2-4 weeks (Convertino, 1991). Willmott et al., 2016 reported no statistically significant changes in resting or [HR.sub.E] after short-term HA. However, applying their predefined analytical limits, significant decreases of 4% (twice daily for 2 days) and 6% (once daily for 4 days) were seen in exercising HR from sessions 1-4, with no change in the control group (1%). These authors reported that this adjustment is typically concurrent with hypervolemia and is recommended to diminish HR by 1 beat.[min.sup.-1] per 1% [DELTA]PV, consistent with their analytical limits and previous investigations (Garrett et al., 2009; Lorenzo et al., 2010; Nielsen et al., 1993; Patterson et al., 2004).

TC and mean [T.sub.s]

Our results failed to show changes in [T.sub.C] and [T.sub.S] after HA. Tyler et al. (2016) reported a moderate-to-large positive impact of HA in reducing the [T.sub.C] prior to and during exercise and they also reported HA had a large impact in decreasing mean [T.sub.S] during exercise, these findings are different from our results. They stated that for short- (< 7 days) and medium-term (8-14 days) HA protocols, the effect sizes for Ts and [T.sub.C] were similar and smaller than in longterm HA (14 days) protocols. There is evidence that people living and training over many weeks in the heat might endure higher maximal [T.sub.C] than those undertaking HA training for just 1 or 2 weeks (Sawka et al., 2001), and trained people can tolerate higher [T.sub.C] (Mora-Rodriguez et al., 2010; Periard et al., 2012). In addition, it has been reported that trained runners completing an 8-km running TT in warm situations are capable of sustaining running velocity, notwithstanding a T.sub.C exceeding 40 [degrees]C (Ely et al., 2009). More recently, it was reported that trained cyclists approach a [T.sub.C] of 40.1-40.2 [degrees]C at the end of a 43.3-km TT in hot situations (Racinais et al., 2015). Consequently, it does appear that raised aerobic fitness presents an enhanced capability to tolerate higher [T.sub.C]. However, the extent to which HA provides such an advantage remains unclear.

Considerable proof of marked alterations in Tc and Ts exist in many physiological and biochemical functions at a crucial temperature in vivo and in vitro, and heterogeneity in thermo sensitivity exists among different tissues (Brinnel et al., 1987). The [T.sub.C] level can rely on several agents such as exercise intensity and duration, fitness, nutrition, dehydration and motivation; and hence would be expected to vary significantly in absolute terms. Moreover, [T.sub.C] relies on the measurement site and the temperature gradients that exist within the body, particularly throughout exercise heat storage (Nielsen et al., 1993; Nielsen et al., 1990).

Blood Lactate

Our results illustrate that blood lactate did not change significantly after HA and this conflicts with recent metaanalysis findings (Tyler et al., 2016). The decrease in blood lactate concentration through submaximal exercise after HA suggests a decline in glycolytic participation from the contracting muscle, and this is known to happen with more traditional HA programs (Febbraio et al., 1994). Moreover, a prior investigation suggested that the blood lactate alteration was in part due to a reduction in sympathoadrenal activation and levels of circulating catecholamines (Febbraio, 2001). Some investigators propose that metabolic conformities caused by HA during exercise are due to a diminishing aerobic metabolic rate (Aoyagi et al., 1994), or diminishing rate of glycogenolysis (Febbraio et al., 1996). Alternatively, the expanded PV and consequently total blood volume (Bass et al., 1955; Harrison et al., 1981) could affect blood lactate concentration via enhanced blood flow to the splanchnic circulation, improving lactate elimination (Rowell et al., 1968), and therefore delaying the onset of blood lactate accumulation.

RPE and [T.sub.Comf]

The change in RPE and [T.sub.Comf] were too small to be meaningful, in agreement with our findings, Tyler et al. (2016) stated HA had a moderate impact on RPE and small impact on [T.sub.Comf]. [T.sub.Comf] is a crucial stimulus which drives voluntary behavior (such as exercise performance and capability) in a warm situation, as it follows seasonal alterations in air temperature (De Dear and Brager, 2001). This emphasizes that [T.sub.Comf] can be improved transiently in the heat via passive exposure to warmer temperatures. [T.sub.Comf] is due to various psychophysical criteria, and it appears logical to recommend that HA could enhance [T.sub.Comf] via shifting exposure to higher temperatures. Nevertheless, data concerning the effectiveness in doing so are currently inadequate to draw firm conclusions. Further investigation is also needed to examine the variation and specificity of adjustment between natural and artificial heat exposure and the potential for unnatural exposure to improve performance in natural competition. HA may vary with the environmental exercise situations to be faced, including the exercise task, solar radiation, and terrain/geography.

Study Quality

Median TESTEX score was 10. Allocation concealment and assessor blinding were not performed in any of the included studies, however this is unavoidable in HA experiments. Only two studies performed intention to treat analyses, this may be a reflection of the relatively low attrition rates due to small sample sizes of included studies, but ITT may also have been simply overlooked in some case where it was indicated . Only two studies adjusted the relative training intensity and this may explain why V[O.sub.2max] and related performance outcomes were unchanged, although by nature HA studies may be of insufficient duration to elicit changes in these parameters.

Limitations

Our meta-analysis has some limitations that should be considered. First, we only analyzed 11 RCTs, and eight of them have small sample sizes (n<20). This argues that more RCTs with larger sample sizes are needed to provide more definitive results. Second, exercise intensity and duration, environmental conditions and period of the HA protocol varied substantially in the utilized RCTs, and this may have impacted our results. Finally, about the data collecting, we calculated the mean differences between pre and post-intervention. Nevertheless, in cases where accurate p values within or between groups or 95% CI were unavailable, default p values were employed, and this may also have impacted our results. Egger plots suggest minimal likelihood of publication bias, indicating there may not be negative, unpublished datasets in existence. However, the small number of studies limited the relevance of Egger plots in these analyses.

Conclusion

HA has a beneficial effect on TT performance, [HR.sub.TT], [HR.sub.M], but was not statistically significant in V[O.sub.2max], [HR.sub.E], [T.sub.C], mean [T.sub.S], PV and blood lactate. The changes in RPE and [T.sub.Comf] were too small to be meaningful. From a high performance coaching perspective, these findings suggest HA improves the athlete's tolerance to discomfort during heat exposure, but may not alter the associated physiological markers of improved performance.

Acknowledgements

The authors report no conflict of interest.

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AUTHOR BIOGRAPHY

Alsaeedi Lafi ALBANAQI

Employment

Masters student in Biomedical Science at the University of New England, Australia.

Degree

BSc

E-mail:aalbanaq@myune.edu.au

Gholam Rasul Mohammad RAHMI

Employment

A doctoral researcher and a teacher in exercise and sports Science and exercise physiology.

Degree

PhD

Research interests

The effects of exercise in people with chronic diseases.

E-mail: rmohammadrahimi@mail.um.ac.ir

Tom van der TOUW

Employment

Senior lecturer in biomedical science at the University of New England, Armidale, Australia.

Degree

PhD

Research interests

Chronic obstructive pulmonary disease, ischaemia-reperfusion and blood flow responses to isometric exercise

E-mail: tvandert@une.edu.au

Neil A. SMART

Employment

Prof School of Science and Technology, University of New England, Australia

Degree

PhD

Research interests

The optimal exercise dose for managing a range of chronic illnesses including heart, lung, metabolic and renal.

E-mail: nsmart2@une.edu.au

([??]) Neil A Smart

School of Science and Technology, University of New England, NSW 2350, Australia

Gholam R. Mohammed Rahimi (1, 2), Alsaeedi L. Albanaqi (3), Tom Van der Touw (1) and Neil A. Smart (1[??])

(1) School of Science and Technology, University of New England, Australia; (2) Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran; (3) Turaif General Hospital, Ministry of Health, Kingdom of Saudi Arabia

Received: 29 January 2019 / Accepted: 10 April 2019 / Published (online): 01 June 2019

Key points

* The primary finding of this analysis is that athletic performance is improved with heat acclimatization training

* Our analysis was unable to determine the physiological variable(s) that are associated with improved performance

* After heat acclimatization training athletes may be able to tolerate greater levels of thermal stress but our analysis was unable to determine physiological markers of adaption
Table 1. Study quality assessment of included studies using the tool
for the assessment of study quality in exercise (TESTEX).

Study            Eligibility   Randomisation  Allocation  Groups
                Criteria       Details        concealed   similar
                specified      Specified                  at baseline

Chalmers 2016    1             0              0           1
Chen 2013        1             1              0           1
Guy 2016         1             1              0           1
Karlsen 2015     1             0              0           1
Kelly 2016       1             1              0           0
Lorenzo 2010     1             1              0           1
Nielsen 1993     1             0              0           1
Peterson 2010    1             1              0           1
Schmit 2017      1             1              0           1
Sunderland 2007  1             0              0           1
Willmott 2016    1             1              0           1

Study            Assessors  Outcomes      Intention   Reporting
                 blinded    measures      to treat    between group
                            assessed      analysis    statistical
                            >85%                      comparison
                            participants

Chalmers 2016    0          3             1           2
Chen 2013        0          2             0           2
Guy 2016         0          2             0           2
Karlsen 2015     0          2             0           2
Kelly 2016       0          2             0           2
Lorenzo 2010     0          2             0           2
Nielsen 1993     0          3             1           2
Peterson 2010    0          2             0           2
Schmit 2017      0          2             0           2
Sunderland 2007  0          2             0           2
Willmott 2016    0          2             0           2

Study            Point        Activity    Relative    Exercise
                 measures &   monitoring  exercise    volume &
                 measures     in control  intensity   Energy
                 of           group       constant    expenditure
                 variability

Chalmers 2016    1            1           0           1
Chen 2013        1            1           0           1
Guy 2016         1            1           1           0
Karlsen 2015     1            1           0           1
Kelly 2016       1            1           0           1
Lorenzo 2010     1            1           0           1
Nielsen 1993     1            1           0           1
Peterson 2010    1            1           0           1
Schmit 2017      1            1           0           0
Sunderland 2007  1            1           0           1
Willmott 2016    1            1           1           0

Study            Overall
                 TESTEX
                 (/15)

Chalmers 2016     11
Chen 2013         10
Guy 2016          10
Karlsen 2015       9
Kelly 2016         9
Lorenzo 2010      10
Nielsen 1993      11
Peterson 2010     10
Schmit 2017        9
Sunderland 2007    9
Willmott 2016     10

Table 2. Meta-analysis of heat acclimation included studies.

Study          HA / C    HA activity
               group

               Study 1:
               9 / 9     Perceptually regulated
Chalmers 2016            treadmill exercise
               Study 2:  training
               12 / 11
Chen 2013      7/7       Cycling at 10% below
                         VT to 10% above VT
                         Cycling at 55 % V[O.sub.2max]
Guy 2016       8 / 8     Cycling at 50, 60, and
                         70 % VO2 max
                         Cycling at 80-100%
                         HRMAX
Karlsen 2015   9 / 9     Cycling at moderate
                         intensity
                         High Intensity Interval
Kelly 2016     7 / 7     Training at 90% and
                         30% V[O.sub.2]
Lorenzo 2010   12/8      Cycling at 50 % V[O.sub.2max]
Nielsen 1993   8 / 5     Cycling at 60 % V[O.sub.2max]
Petersen 2010  6 / 6     High intensity cycling
                         Low intensity training or
Schmit 2017    19/10     High intensity training
Sunderland     12 / 5    Loughborough
2007                     Intermittent Shuttle Test
Willmott 2016  14 / 7    Cycling at 50 % V[O.sub.2max]

Study           Intervention group: HA
                frequency and duration


                Study 1:
                5 days x 38 min in 35 [degrees]C
                and 30% RH
Chalmers 2016   Study 2:
                4 days x 58 min in 35 [degrees]C
                and 30% RH
                5 days x 35 min (mean)
Chen 2013       in 38.4[degrees]C [+ or -] 0.4[degrees]C, 52.0%
                [+ or -] 4.6% RH
                7 days x 40 min at 35[degrees]C
                and 70% RH
Guy 2016        3 HST tests x 3 sets x 10
                min at 35 [degrees]C and
                70 % RH
                14 days x 38 min in
                35 [degrees]C
Karlsen 2015    14 days x 90 min in
                35 [degrees]C
                5 sessions x 27 min in
Kelly 2016      38.7 [+ or -] 0.5 [degrees]C; 34.4 [+ or -] 1.3
                % RH
                10 days x 2 bouts x 45
Lorenzo 2010    min with 10 min rest in
                40[degrees]C and 30% RH
Nielsen 1993    9-12 days x 90 min in 40-
                42[degrees]C and 10-15% RH
Petersen 2010   4 days x 38 min (mean)
                in 30[degrees]C, 60% RH
                5 days x 60 min in 30[degrees]C,
Schmit 2017     50% RH
Sunderland      4 sessions x 38 min
2007            (mean) in 30[degrees]C, 24% RH
                SDHA:
                4 days x 45 min in 35.2
                [+ or -]0.5[degrees]C, 60[+ or -]2% RH
Willmott 2016   TDHA:
                2 days x 2 sessions x 45
                min in 35.4[+ or -]0.8,
                61[+ or -]3% RH

Study          Control group:
               frequency and
               duration

               Study 1:
               5 days x 38 min in
               19 [degrees]C and 30% RH
Chalmers 2016  Study 2:
               4 days x 58 min in
               19 [degrees]C and 30% RH
               5 days x 35 min
Chen 2013      (mean) in 24.1[degrees]C [+ or -]
               0.3[degrees]C, 51.5% [+ or -]
               4.5% RH
               7 days x 40 min at
               20?C, 45% RH
Guy 2016       3 HST tests x 3 sets
               x 10 min at 35 ?C
               and 70 % RH
               14 days x 38 min in
               5-13[degrees]C
Karlsen 2015   14 days x 90 min in
               5-13[degrees]C
               5 sessions x 27 min
Kelly 2016     in 22.3 [+ or -] 0.2 [degrees]C;
               35.8 [+ or -] 0.6 % RH
               10 days x 2 bouts x
               45 min with 10 min
Lorenzo 2010   rest in 13[degrees]C and
               30% RH
               9-12 days x 90 min
Nielsen 1993   in 18-20[degrees]C and 10-
               15% RH
               4 days x 38 min
Petersen 2010  (mean) in 20[degrees]C,
               60% RH
               Undertook some
               training sessions in
Schmit 2017    the lab at 21[degrees]C,
               50% RH
               4 sessions x 38 min
Sunderland     (mean) in 18[degrees]C,
2007           41% RH
               4 days x 45 min in
Willmott 2016  21.7[+ or -]0.6[degrees]C, 39[+ or -]5
               % RH

Study          Measure             Performance
               (Outcome)           test

               HRE, TC,
               VO2max, PV,
Chalmers 2016  Blood Lactate,      -
               TComf, RPE
                                   Maximal leg
                                   cycle exercise
Chen 2013      V[O.sub.2max],      test (GXT):
               Performance,        time
               TS, HRM             to reach
                                   exhaustion
               TC,
Guy 2016       Performance,        5 km TT
               HRTT, RPE,          performance
               TComf, HRE
Karlsen 2015   V[O.sub.2max], PV   -
Kelly 2016     HRE, TS,            -
               RPE, TComf
               TC, V[O.sub.2max],
Lorenzo 2010   TS, HRM, PV,        -
               Blood Lactate,
Nielsen 1993   TC, TS, PV          -
               HRE, TC, TS,
Petersen 2010  Blood Lactate,      -
               TComf
                                   20-km cy-
               Performance,        cling TT in
Schmit 2017    TC, HRTT,           35[degrees]C,
               RPE                 50% RH
               TC, HRE, PV,
Sunderland     Blood lactate,      -
2007           RPE, TComf
               Performance,        3 km TT
Willmott 2016  HRE, TC, PV,        performance
               HRTT, RPE           in 30 [degrees]C,
                                   60% RH

HA = Heat Acclimation, HR = Heart Rate, RH = Relative Humidity, PV =
Plasma Volume, VT = Ventilator Threshold, HST = Heat Stress Tests,
[HR.sub.TT] = Heart Rate Time Trial, [T.sub.C] = Core Temperature,
[T.sub.S] = Skin Temperature, [HR.sub.E] = Exercising Heart Rate, RPE =
Rate of Perceived Exertion, TComf = Thermal Comfort, [HR.sub.M] =
Maximum Heart Rate, HIIT = High Intensity Interval Training, SDHA =
Single Session Per Day Heat Acclimation, TDHA = Twice Daily Heat
Acclimation.
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Author:Rahimi, Gholam R. Mohammed; Albanaqi, Alsaeedi L.; Van der Touw, Tom; Smart, Neil A.
Publication:Journal of Sports Science and Medicine
Geographic Code:8AUST
Date:Jun 1, 2019
Words:7582
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