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Phylogeny of the mononegavirales and evolutionary divergence of the structural glycoprotein gene.

Emerging infectious diseases of economically important animals such as fish and poultry, as well as lethal infections in humans are caused by members of the Mononegavirales. Phylogenetic relationships among members of the negative-sense RNA viral order Mononegavirales were examined using sequences of the structural glycoprotein. In addition to elucidating evolutionary relationships within the order, the phylogeny will serve as to tool for examination of epitope regions of the glycoprotein by identifying independent viruses for comparison. Identifying the rates and locations of particular types of substitutions within epitopes regions is paramount for understanding how to manage and treat potentially dangerous viruses. A neighbor-joining tree was generated from a multiple amino acid alignment using uncorrected p-distance. The phylogeny identified clusters corresponding to the known families within the order: Rhabdoviridae, Paramyxoviridae, Filoviridae, and Bornaviridae. A cluster including the genus Ebolavirus was found to be basal. Within the Rhabdoviridae, we investigated infectious hematopoietic necrosis virus (IHNV) and viral hemorrhagic septicemia virus (VHSV) whose placements in the family remain controversial, as well as the unclassified Sigma virus and a trout isolate known as Rhabdovirus 903/87. Contrary to previous reports in which VHSV is linked with the rest of the Lyssavirus group, our analysis showed a well-supported clade comprised of VHSV and IHNV. In addition, we found members of the Vesiculovirus group, including the trout rhabdovirus 903/87, to be more closely related to the Lyssavirus group than to the VHSV/IHNV clade. The unclassified Sigma virus was found to be associated with members of the Ephemerovirus group. *Supported by Winthrop Research Council Grant
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Title Annotation:SOUTH CAROLINA ACADEMY OF SCIENCE ABSTRACTS
Author:Ledbetter, Kristen; Westover, Kristi M.
Publication:Bulletin of the South Carolina Academy of Science
Date:Jan 1, 2005
Words:259
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