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Phase 3 Detox.

Is one of the biggest mistakes you 're making as a practitioner not properly supporting phase 3 detoxification ?

In this day and age, the air we breathe, the water we drink and the food we eat is chalked full of a multitude of toxins such as heavy metals, plastics, pesticides, volatile chemicals and other environmental toxins that place a large burden on our bodies. Our patients come to us seeking help for various health complaints but foundational support is typically where we all start in order to help set the stage for their healing. One of the most important foundations of health is detoxification. Lessening their toxic-load is key in order to begin to treat their health ailments.

Detoxification refers to the process of taking endogenous substances such as hormones and endogenous compounds such as heavy metals and making them water-soluble so that they will be able to be excreted from the body in the bile or urine.

Practitioners are typically good at supporting the organs of detoxification (liver & kidneys) but fail to "seal the deal" by not using intestinal binders properly or if they do use binders they are not broad-enough range to bind a plethora of toxins.

Selective intestinal binders used in tandem to cover a broad-range of toxins are a crucial part of any detox protocol When the liver processes toxins, they get excreted through bile and into the small intestine. If the toxins are not bound to anything, most of them will get reabsorbed in the gut. This is called enterohepatic recirculation. Binders ensure the products of Phase 1, 2 & 2.5 Detoxification are actually excreted fully from the body through elimination.

There are a variety of intestinal binders available for safe use. Different binders have selective affinities for various toxins based on their net charge and molecular bonds. The following are some of the most commonly used binders and the substrates to which they bind:

Activated charcoal:

pathogenic bacteria, mold toxins, pesticides, herbicides, volatile organic compounds (VOCs).


ochratoxin, polychlorinated biphenyls (PCBs), phthalates, BPA, endotoxin, metals, also has prebiotic activity *not indicated for those with shellfish allergy


metals,VOCs, pesticides, herbicides and mycotoxins.


aluminum and other trivalent metals (thallium).


mold toxins, bisphenol A (BPA), pesticides and herbicides, healing to GI lining.

Cholestyramine and Welchol:

These are prescription medications that were developed to bind cholesterol. Commonly used to bind to mycotoxins, but they can decrease absorption of fatsoluble vitamins over time.

Humic and Fulvic Acids:

These are made of decomposed plant matter, essentially dirt. They have been shown to detox glyphosate but can cause renal damage.

Selecting a binder that will actively bind many environmental and endogenous toxins is imperative in properly executing all phases of detoxification, which is part of a much-needed foundation of care in those with chronic illness.

About the Author

Dr. Kelly Halderman, MD, PSc.D completed a Family Practice Medical Internship with the University of Minnesota; has a Naturopathic Medical Degree from the Kingdom College of Natural Health where she is the current Academic Dean of Students. She is on the medical advisory board for NutriGenetic Research Institute and holds certification in MethylGenetic Nutrition[R] and Functional Neurology from the American Functional Neurology Institute. Dr. Halderman is currently completing her Ph.D in clinical nutrition and has a certification in Plant based Nutrition from Cornell University. Her practice interests include Chronic Lyme, of which she has personally had to fight and overcome, Cancer, & genetic optimization and mitochondrial restoration.

by: Kelly Halderman, MD, PSc.D
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Author:Halderman, Kelly
Publication:Original Internist
Date:Sep 1, 2018
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