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Periodontal Tx failed to lower preterm births: pregnant women with periodontal disease fared the same whether their disease was treated or not.

Treating periodontal disease in pregnant women does not decrease their chances of preterm birth, according to a study of 756 women.

Several previous studies have found that pregnant women with periodontal disease have an increased likelihood of giving birth prematurely.

But this was the first study to use a randomized controlled trial to test the idea that treating periodontal disease may improve a woman's chances of carrying her pregnancy to term.

Periodontal disease is very common, affecting more than 30% of individuals in some populations. The investigators, led by Dr. George A. Macones of Washington University in St. Louis found that 50% of the 3,563 pregnant women they screened had either gingivitis or periodontitis (Am. J. Obstet. Gynecol. 2010; 202:147e1-8).

Women were included in the study if they had periodontal disease and were 6-20 weeks pregnant. They were excluded if they had already received periodontal treatment during their pregnancy, if they had used antibiotics or antibiotic mouthwash within 2 weeks, if they had a multiple pregnancy, or if they had known mitral valve prolapse.

The 376 women in the active treatment group received thorough periodontal treatment, in which trained dental hygienists removed stains, plaque, and calculus above and below the gum line, leaving the root surfaces smooth and clean. The 380 women in the control group received only a superficial cleaning and stain removal above the gum line.

The primary outcome was spontaneous preterm birth, which the investigators defined as births occurring before 35 weeks' gestation.

Secondary outcomes included the type of preterm birth (either spontaneous or indicated), delivery before 37 weeks' gestation, gestational age at delivery, birth weight, and major neonatal adverse outcomes, such as death, sepsis, and chronic lung disease.

There were no significant differences between active treatment and control groups on any of these measures. Investigators did, however, find one significant difference within the planned subgroup analyses: Among women with a history of previous preterm birth, those in the active treatment arm had a greater risk of preterm birth than those in the control treatment arm.

The investigators suggested that this one statistically significant result among many results that were not significant may have arisen by chance.

In an accompanying editorial, Dr. Kim A. Boggess of the University of North Carolina at Chapel Hill offered another possibility. Dr. Boggess suggested that scaling and root planing may have disseminated oral pathogens or their toxins to the rest of the body, accounting for the apparently increased risk of active treatment in this one subgroup of women (Am. J. Obstet. Gynecol. 2010;202:101-2).

Regarding the idea of treating pregnant women for periodontal disease, Dr. Boggess wrote: "Although promising, the current data do not support periodontal treatment during pregnancy to reduce the preterm birth risk."

However, she also said that the trial "confirmed that periodontal treatment improves the oral health of pregnant women, and oral health for the sake of oral health cannot be disputed."

VITALS

Major Finding: There was no significant difference between pregnant women who received treatment for periodontal disease and those who did not in terms of spontaneous preterm birth, gestational age at birth, or major neonatal adverse outcomes.

Data Source: Randomized, controlled trial of 756 pregnant women with periodontal disease.

Disclosures: The study was supported by the Pennsylvania Department of Health, the National Center for Research Resources, and the National Center on Minority and Health Disparities. No conflicts of interest were reported.
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Title Annotation:OBSTETRICS
Author:Finn, Robert
Publication:OB GYN News
Article Type:Clinical report
Date:Mar 1, 2010
Words:568
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