Peony for myocardial infarct.
The roots of Paeoniae rubrae have been used in Asian medicine for thousands of years in the treatment of conditions from dementia to diabetes. The glucosides are suggested to have antiallergic, anti-inflammatory, immunoregulatory and antioxidant activities.
In order to assess the effects of the plant on cardiovascular disease, researchers induced acute myocardial infarction (AMI) in a number of rats. Animals were randomly divided into six groups: a control, a sham operation group, those with induced AMI, those with AMI plus Paeoniae extract (PE) low dose, AMI and PE high dose and AMI plus isosorbide dinitirite positive control.
The extract utilised was prepared from the dried root of the plant with 70% alcohol. It contained 25 mg/ mL of paeoniflorin in water. Those animals in active groups received the herbal preparation by intragastric administration for 6 days (2 mL twice/day.) Low dose was considered to be 5 mg/mL and high dose was 25 mg/mL.
In comparison with control animals, those with AMI exhibited increased levels of the inflammatory cytokines IL-10 and TNF[alpha]. Dosage with PE or positive control inhibited this increase by between 60% and 85%. There was also a decrease in markers of oxidative stress. Changes in other markers suggested that PE may inhibit collage hyperplasia, lessen the interstitial fibrosis of cardiac muscle and increase compliance of cardiac muscle to improve the heart's diastolic function in AMI rats.
Injury to the cardiac muscle in AMI due to myocardial ischemia results in increases of serum myocardial enzymes, such as creatine kinase isoenzyme MB (CKMB). In the current study administration of high dose PE had a significant positive effect in preventing this. Paeonia extract also inhibited rises in a number of other myocardial enzymes in a dose dependant manner. Further measurements indicated that AMI may induce apoptosis in cardiomyocytes, and that PE may protect against this.
Overall PE has a beneficial effect on cardiac muscle, protecting it from:
* damage to cytomembranes
* outleakage of myocardial enzymes
* decreases in blood anticoagulating ability and antioxidant defences
* AMI induced increased in IL-10 and TNF[alpha].
Radix paeoniae rubrae may be of benefit clinically for treating cardiovascular diseases and reducing the negative repercussions of AMI.
Tessa Finney-Brown MNHAA
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|Publication:||Australian Journal of Medical Herbalism|
|Date:||Jun 22, 2011|
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