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Pediatric weight loss. (Clinical Capsules).

Metformin shows potential for controlling weight gain in pediatric patients taking psychotropic drugs, said John A. Morrison, Ph.D., of the Children's Hospital Medical Center, and his colleagues.

While taking valproate, olanzapine, risperidone, or quetiapine for bipolar disorder and psychosis, 15 of 19 patients lost weight with metformin, a drug normally prescribed for patients with noninsulin-dependent diabetes to control blood sugar levels; 1 patient had no change in weight, while 3 others gained no more than 1.6 kg. Patients were restricted from changing their diet or level of physical activity during the course of the study (Am. J. Psychiatry 159[4]:655-57, 2002).

At 4 weeks, all 19 patients had lost a mean of 0.93 kg. At 8 weeks, 16 patients who remained in the study lost a mean of 1.05 kg. By the end of the 12-week trial, the 12 remaining patients lost a mean of 2.93 kg and had decreased their body mass index by a mean of 2.22 kg/[m.sup.2].
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Author:Evans, Jeff
Publication:Clinical Psychiatry News
Article Type:Brief Article
Geographic Code:1USA
Date:Jun 1, 2002
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