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PathAlert Infectious-Agent Detection System.

PathAlert[TM] Detection System, a cost-effective screening and confirmatory detection system for infectious agents, has undergone successful evaluations coordinated by the U.S. Department of Defense and the U.S. Environmental Protection Agency (U.S. EPA). In those tests, the system was shown to be sensitive and specific for the identification of air and waterborne pathogens.

The PathAlert Detection System can be used by government, military, and research organizations for accurate detection of infectious agents such as Bacillus anthracis (anthrax), Yersinia pestis (plague), Vaccinia (smallpox simulant), and Francisella tularensis (tularemia) in samples collected from the air, food, and water. According to the U.S. EPA assessment, the system accurately detected infectious agents such as anthrax and plague in drinking water with no false positives or false negatives at expected sensitivity levels.

Each PathAlert Detection Kit is a reagent system optimized for the detection of a specific infectious agent. Based on multiplex-PCR, the kits detect multiple regions of pathogen DNA and include internal and external controls, greatly reducing false-positive and false-negative readings. Using the PathAlert multiplex-PCR kits with the Agilent 2100 bioanalyzer and DNA chip and reagent kits, users can monitor DNA targets and controls simultaneously without the constraints imposed by conventional real-time PCR. Agilent's 5100 Automated Labon-a-Chip Platform can be used for biodefense applications requiring high-throughput analysis. The PathAlert System also provides less costly capabilities for detecting anthrax, plague, smallpox simulant, and tularemia.

The system also offers the unique capability of multi-agent analysis in a single assay based on the biothreat agents of interest in a specific matrix, such as water, food, or animal feed. It is being co-marketed by Invitrogen Corporation and Agilent Technologies, Inc.

For more information on the PathAlert System, contact Greg Geissman by phone at (760) 476-7032 or by e-mail at, or visit
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Title Annotation:Products & Services
Publication:Journal of Environmental Health
Date:Oct 1, 2005
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