PHARMACOLOGICAL STUDIES EXAMINING THE EFFECTS OF CHOLINERGIC AGENTS ON THE EMBRYONIC CHICK PANCREAS.
Avian carbohydrate metabolism is regulated by a multifaceted of neural, nutrient and hormonal components. The pancreaticoduodenal nerve plexus supplies the exocrine portion of the avian pancreas. An embryonic whole organ culture system has been developed to determine whether the muscarinic receptor for the chick pancreatic cells is functionally similar to the mammalian muscarinic receptors. Pharmacological levels of synthetic muscarinic agonists and antagonists have demonstrated the regulatory role of the muscarinic receptors for the embryonic chick exocrine pancreas. Through immunohistochemical studies in our lab we have localized amylolytic enzymes in the chick embryonic pancreas. In addition, cryosectioning and indirect immunofluorescent techniques will be used to determine muscarinic (M3) receptor subtype specificity in the embryonic chick pancreas. These studies will be important for understanding neural regulation of the exocrine pancreas and will examine the differences between avian and mammalian carb ohydrate metabolism.
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|Publication:||Journal of the Alabama Academy of Science|
|Article Type:||Brief Article|
|Date:||Apr 1, 2001|
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