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PATHOPHYSIOLOGICAL ASPECTS OF CHANGES IN THE VASCULAR SYSTEM OF PERIODONT IN INFLAMMATION.

Introduction: periodontal disease is a chronic inflammatory process occurring in the the complex of tissues supporting the tooth named periodont. A gradual degradation of periodontal tissues in periodontal disease finally leads to the loss of a tooth. According to scientific data, periodontal disease is a particular kind of the systemic inflammatory process in the body, the causative factor of which is the dysfunction of vascular endotheliocytes.

Aim: to evaluate the pathophysiological features of vascular changes of periodont in periodontal disease

Methods: study of patient's case histories, collection of anamnestic data, visual examination of the oral cavity, assessment of marked changes in periodontal disease, doppler ultrasonography

Results: the study of case histories of 15 patients showed that the middle age of patients was 40 years. Psycho-emotional stress and insufficient chewing are noted. Doppler ultrasonography study showed hemodynamic changes in periodontal vessels, that indicates a decrease in the elastic properties of the vascular wall. Because of various inadequate effects on periodont, uncontrolled endothelium-dependent synthesis of NO occurs in local vessels. It leads to the vasodilation. Long-term expansion of blood vessels leads to the alteration of the vascular wall that is accompanied by increased synthesis of inflammatory mediators - cytokines, adhesins, IL-1, TNF-[alpha], prostaglandins. During the visual examination of oral cavity, such signs of the inflammation as swelling of the gums, hyperemia and bleeding are noted. The pathogenic influence of the microflora of plaque and subgingival zone is activated. Probably, mediators induce the synthesis of other mediators that leads to the weakening of local immunity. Bacteria (anaerobic bacilli and spirochetes) actively penetrate into the bloodstream and cause systemic uncomplicated bacteremia.

Conclusions: periodontal disease is characterized not only by the typical signs of inflammation but by specific ones too, such as the cyclic chain of synthesis of mediators, uncomplicated bacteremia and secondary infection with auto-flora. The starting stimulus for alteration is probably the uncontrolled synthesis of nitric oxide.

J. Babadjanov, P. Sharipova

Tashkent State Dental Institute

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Author:Babadjanov, J.; Sharipova, P.
Publication:Journal of Asian Medical Student Association
Article Type:Report
Geographic Code:9UZBE
Date:Jun 1, 2019
Words:322
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