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PALMAR DERMATOGLYPHICS IN PATIENTS WITH DIABETES MELLITUS TYPE II AND HYPERTENSION IN THE AGE GROUP OF 35-55 YEARS.

BACKGROUND

Dermatoglyphics is a branch of genetics dealing with skin ridge system. The study of epidermal ridges, patterns formed by them in palmar and plantar regions and flexion creases is known as dermatoglyphics. Ridges are genetically determined and influenced by environmental, physical and topographical factors. [3] Dermatoglyphics is a growing discipline and its ease and ready applicability renders it as a useful tool to the clinician.

The relevance of dermatoglyphics is not to diagnose but to prevent by predicting a disease; not for defining an existing disease but to identify people with genetic predisposition to develop certain diseases. In the present study, we try to determine significant palmar dermatoglyphic parameters in case of diabetes mellitus type 2 and essential hypertension in the age group between 35-55 years. It indicates that there are some genetic factors in the causation of diabetes mellitus type 2 and essential hypertension. Like clinical history, examination and investigations, dermatoglyphics will play an important role in revealing the genetic susceptibility to diabetes mellitus type 2 and essential hypertension.

The term dermatoglyphics (Greek- derma- skin, glyphic-carvings) is the scientific term coined by Anatomist Prof. Harold Cummins of Tulane University in 1926 in the United States (Penrose). The analysis of dermal ridges and their configurations by studying prints of them is called dermatoglyphics. The term is also used as a collective name for all the features of ridged skin. The skin patterns are studied from prints and impressions. The study of dermatoglyphics was pioneered long back by Galton in 1892. The dermal ridge differentiation takes place early in foetal development, evident around 6th week of gestation and reach maximal size by the 12th to 13th week. By the 4th month, the epidermal ridges are nicely developed, but the process is probably not complete before the 6th month of gestation (Alter). Patterns once established never change throughout life. The significance of dermatoglyphic science is based upon two major facts (4)-a) The ridges remain throughout life and survive superficial injury, in other words they are age stable, permanent and also environment stable after 21st week of intrauterine life; b) The ridges are slightly different for each finger and differ from person to person.

MATERIALS AND METHODS

The study was a descriptive comparative study carried out for over a period of one and a half years from October 2005 to March 2007 with minimum sample of 100 patients. The material for study consisted of patients selected from those attending BLDEA's Shri. B. M. Patil Medical College, Hospital and Research Centre, Bijapur. Patients between age group of 35-55 years who were diagnosed as diabetes mellitus type 2 and hypertension were taken for the study by convenient sampling technique. Finger and palm prints of 100 normal persons, i.e. control group were obtained from the outpatient department and staff of Department of Anatomy in the age group between 35-55 years. Control group was diagnosed by laboratory tests having (fasting blood sugar < 126 mg/dL, post prandial sugar < 200 mg/dL, fasting and post prandial urine sugars--nil) and recording of blood pressure (< 140/190 mmHg).

Patients were asked to wash both hands with soap and water, so as to remove any oil or dirt. Obtaining of prints was as follows: Black kajal was smeared on both hands one by one and prints were taken by rolling the hands from wrist crease to fingertips on bond paper. The fingers were rolled sideways, so that the whole ridge pattern present on distal aspect of digit (Including the distal interphalangeal crease) was recorded for the palm prints, the person's hand was pressed using even pressure on the dorsum of the hand.

Inclusion and Exclusion Criteria: Patients with deformed finger and palm prints, infection and injuries like burns of fingers and palms, scars of burns of fingers and palms of both hands, patients with type 1 diabetes mellitus, patients with only type 2 diabetes mellitus without hypertension and patients with only hypertension without type 2 diabetes mellitus were excluded from the study.

Statistical Analysis

The Arithmetic mean and standard deviation were calculated. Z-test was applied. Software used is SPSS 16.0 for statistical analysis.

Significance

For the value of Z, the critical value of P is obtained from the normal table for 5% level of significance.

Parameters

The quantitative study included mean total finger ridge count (TFRC), mean absolute finger ridge count (AFRC), mean 'a-b' ridge count and mean 'a-t-d' angles. The qualitative study included fingerprint patterns (arches, radial loops, ulnar loops and whorls) and palmar patterns (Simian line and Sydney line). Statistical analysis was done.

RESULTS

DISCUSSION

Study conducted on diabetes mellitus by Ravindranath and Thomas M and also by Verbov(5) showed increase in number of arches. Sant et al(6) showed reduced frequency of radial loops in male diabetics and frequency of ulnar loops reduced in diabetes of both sexes. However, Ravindranath and Thomas found increased radial loops. Verbov and Ravindranath and Thomas found low incidence of whorls, while Sant et al and Ahuja et al(7) found higher incidence of whorls in diabetics.

Study conducted on patients having hypertension by Pursnani et al(8) showed increase in number of arches. According to Jain et al,(9) there was decrease in ulnar loop and Pursnani et al and Godfrey et al showed non-significant difference in ulnar loops on hypertensives. Pursnani et al found higher frequency of whorls. According to Igbigbi et al, whorls were absent in digits of all patients.

In the present study, there were increased ulnar loops and whorls with both hands combined in female patients and decreased whorls with both hands combined in male patients (Table 1).

In studies conducted by Sant et al and Ahuja et al on diabetes found no significant difference. Godfrey et al and Pursnani et al in their study on hypertension observed a decrease in the 'a-t-d' angle.

Verbov, Ahuja et al and Ravindranath and Thomas in their study of non-diabetes mellitus noted an increase in the total finger ridge count. Studies on hypertension by Jain et al and Pursnani et al also showed an increase in TFRC.

Godfrey et al,(10) in their study on hypertension have reported a significant increase in AFRC.

Studies by Ravindranath and Thomas and Ahuja et al on diabetes mellitus showed no significant difference in 'a-b' ridge count.

In the present study, there was decrease in 'a-b' ridge count in the left hand of female patients with diabetes mellitus and hypertension as compared to controls (Table 5).

Verbov observed 7.5% of Sydney line in control male and none in diabetics. In females he noted 11.25% in control and 2.6% in diabetics.

Verbov found 2.9% of diabetic males showed Simian line and 6.25% showed in control. He also showed 5.3% presence of Simian line in females and none in control.

In the present study, there was increase in Simian line in the left hand of female patients with diabetes mellitus and hypertension compared to controls (Table 7).

No significant difference was observed in case of either hand, combined or separate in both sexes in a-t-d angle, TFRC, AFRC and Sydney line in the present study (Tables 2, 3, 4 and 6).

CONCLUSION

Dermatoglyphics, the study of small ridges in palms and soles has proved its importance at least in 3 fields--medicolegal, anthropological and clinical. It is not only a help to the clinicians, but to the cytogeneticists too for resolving the problems in chromosomal identification. This study is also helpful in cases where cytogenetic studies are not possible, e.g. in a pathological specimen, autopsied or aborted materials.

REFERENCES

[1] Penrose LS. Medical significance of finger-prints and related phenomena. Br Med J 1968;2(5601):321-5.

[2] Penrose LS, Ohara PT. The development of the epidermal ridges. J Med Genet 1973;10(3):201-8.

[3] Alter M. Dermatoglyphic analysis as a diagnostic tool. Medicine (Baltimore) 1967;46(1):35-56.

[4] Ravindranath R, Thomas IM. Finger ridge count and finger print pattern on individual finger in maturity onset diabetes mellitus. J Anat Sciences 1995;14(2):32-6.

[5] Verbov JL. Dermatoglyphics in early-onset diabetes mellitus. Human Hered 1973;23(6):535-42.

[6] Sant SM, Vare AM, Fakruddin S. Dermatoglyphics in diabetes mellitus. J Anat Soc India 1983;32(3):127-30.

[7] Ahuja YR, Iqbal MA, Khubchand J, et al. Dermatoglyphics in diabetes mellitus type 2 Revisted. In: Human biology. Recent advances. New Delhi, India: Today and Tomorrow's Printers and Publishers 1981;2:1-24.

[8] Pursnani ML, Elhence GP, Tibrewala L. Palmar dermatoglyphics in essential hypertension. Indian Heart J 1989;41(2):119-22.

[9] Jain PK, Sharma BK, Mathur BD. Dermatoglyphics in essential hypertension. J Assoc Physicians India 1984;32(4):335-7.

[10] Godfrey KM, Barker DJP, Peace J, et al. Relation of fingerprints pattern and shape of the palm to foetal growth and adult blood pressure. Br Med J 1993;307(6901):405-9.

Sumathi Shekar (1)

(1) Assistant Professor, Department of Anatomy, Bangalore Medical College and Research Institute, Bangalore, Karnataka.

'Financial or Other Competing Interest': None.

Submission 23-04-2018, Peer Review 05-05-2018, Acceptance 07-05-2018, Published 14-05-2018.

Corresponding Author:

Dr. Sumathi Shekar, Department of Anatomy, Bangalore Medical College and Research Institute, Bangalore, Karnataka.

E-mail: sumathishekar@gmail.com

DOI: 10.14260/jemds/2018/550
Table 1. Frequency of Patterns (Both Hands)

Pattern    Male     Female     Male     Female      P       Inference
          Patient   Patient   Control   Control    value

Arch        18        16        14        04       <0.05        S

Whorl       140       259       262       133      <0.05        S

Radial      05        09        04        11       <0.05        S
loop

Ulnar       237       316       350       222      <0.05        S
loop

Table 2. Mean 'a-t-d' Angle (SD in Brackets)

        Hand     Patients      Controls    Z-test  P-value  Inference

Male    Left   41.28 (4.92)  41.76 (5.93)   0.45   >=0.77      NS
        Right  41.98 (6.44)  41.03 (5.6)    0.78   >=0.43      NS

Female  Left   40.60 (4.04)  41.75 (5.29)   1.14   > =0.25     NS
        Right  40.38 (3.71)  40.73 (4.15)   0.42   >=0.67      NS

Table 3. Mean TFRC (SD in Brackets)

         Patient   Controls   Z-test   P-value    Inference

Male      121.9     134.98     1.58    >=0.1141      NS
         (39.88)   (42.680

Female   132.68     126.19     0.83    >=0.4066      NS
         (40.83)    (35.1)

Table 4. Mean AFRC (SD in Brackets)

         Patient   Control   Z-test    P-value    Inference

Male     157.77    186.35     1.77    >=0.07677      NS
         (78.89)   (80.62)

Female   181.55    156.13     1.79     >=0.07        NS
          (73)     (62.74)

Table 5. Mean 'a-b' Ridge Count

         Hands   Patient   Control   Z-test    P-value    Inference

Male     Left     37.42     37.55    Z=0.11   >=0.9124       NS
                 (5.66)    (5.64)

         Right    35.92     35.68    Z-0.21   >=0.8414       NS
                   (6)     (5.38)

Female   Left     37.07     40.54    Z=2.99   P<=0.0028      HS
                 (6.01)    (5.68)

         Right    37.2      37.81    Z=0.01    P>=0.99       NS
                 (5.13)    (6.04)

Table 6. Presence of Sydney Line

         Hands   Patient (%)   Controls (%)   Inference

Male     Left       1.01            0            NS
         Right        0             0

Female   Left         0             0            NS
         Right        0             0

Table 7. Presence of Simian Line

         Hands   Patients (%)   Controls (%)   Inference (Z-test)

Male     Left     06 (6.06)      02 (2.02)         NS, P>0.05
         Right    04 (4.04)      02 (2.02)         NS, P>0.05

Female   Left     12 (12.12)     04 (4.04)         S, P<0.05
         Right    04 (4.04)      03 (3.03)         NS, P<0.05
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Title Annotation:Original Research Article
Author:Shekar, Sumathi
Publication:Journal of Evolution of Medical and Dental Sciences
Article Type:Report
Geographic Code:9INDI
Date:May 14, 2018
Words:1896
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