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Oxidative potential as biomarker of PM exposure.

Numerous epidemiological studies have documented the effects of particulate matter (e.g., [PM.sub.10], [PM.sub.2.5]) air pollution on morbidity and mortality from respiratory and cardiovascular diseases. Although oxidative stress appears to be a critical mechanism by which exposure to PM causes adverse health effects, its use as a biomarker of exposure has been limited. Boogaard et al. (p. 185) assessed the oxidative potential of PM collected at major urban streets and background locations, the relationship between oxidative potential with other PM characteristics, and the oxidative potential of different PM size Fractions. They measured [PM.sub.10], [PM.sub.2.5], soot, and the elemental composition and oxidative potential of PM simultaneously in samples from 8 major streets and H) urban and suburban background locations in the Netherlands. Six 1-week measurements were performed at each location over a 6-month period in 2008. The [PM.sub.10] oxidative potential was 3.6 times higher for samples from major streets than for samples from urban background locations, exceeding the contrast for PM mass, soot, and all measured chemical PM characteristics. The contrast between major streets and suburban background locations was even higher (factor 6.5). Oxidative potential was highly correlated with soot, barium, chromium, copper, iron, and manganese. The oxidative potential of [PM.sub.10] was 4.6 times higher than the oxidative potential of [PM.sub.2.5] when expressed per volume unit and 3.1 times higher when expressed per mass unit. The results of this study suggest that measures of oxidative stress could serve as biologically relevant indicators of exposure to air pollutants.
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Title Annotation:Research; particulate matter
Publication:Environmental Health Perspectives
Article Type:Brief article
Geographic Code:1USA
Date:Feb 1, 2012
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