Printer Friendly

Outcome following open and laparoscopic Cholecystectomy.

INTRODUCTION:

* Gastro-intestinal surgery has undergone a revolution in the recent years by the introduction of laparoscopic techniques.

* Acute acalculous/calculous cholecystitis, which continues to be one of the most common digestive disorders encountered, was traditionally being dealt by conventional (open) cholecystectomy. With the introduction of laparoscopic cholecystectomy, the surgical community witnessed a revolution in post-operative recovery of the patient.

* Laparoscopic cholecystectomy (LC) is safe and easy, which can be performed with much ease and safety because of the better magnification.

* LC has shown clear benefits in terms of shortened hospital stay, less morbidity, a quicker return to work and with cosmetic advantage.

* Some surgeons have suggested that the rates of serious complications, particularly bile duct injury might be significantly higher in laparoscopic procedure.

* The high costs of the laparoscopic equipment and the specialized training that is mandatory for mastery of the technique, the procedure inherently carries hazards and risks.

* Could laparoscopic cholecystectomy establish itself as a safe and cost effective alternative to the open method?

* In our study, we have planned an attempt to compare the advantages and drawbacks of both the procedures.

OBJECTIVES: The aim of this study is to compare conventional cholecystectomy and laparoscopic cholecystectomy with respect to:

1. Duration of the procedure.

2. Post- operative recovery.

3. Analgesic requirement.

4. Complications encountered.

5. Period of hospitalization.

6. Patient satisfaction.

METHODOLOGY: The study subjects were patients, admitted with diagnosis of acute acalculous/calculous cholelcystitis, who subsequently underwent cholecystectomy at Adichunchnagiri institute of medical sciences, BG nagara, between November 2010 and April 2012.

All the patients were selected randomly, and as per the proforma, all the patients were interviewed for detailed clinical history and examined. They were then subjected to routine blood, urine and other investigations and an abdominal ultrasound was performed in all cases.

INCLUSION CRITERIA: Patients with acute calculous/acalculous cholecystitis, proven by USG with at least one attack of upper abdominal pain and considered fit for elective cholecystectomy were included in the study.

EXCLUSION CRITERIA: The patients with following conditions were excluded from the study:

* History or investigations suggesting CBD stones. History of prior abdominal surgery.

* Patient's age above 70 years.

* Patients of coagulopathy and those on Anti-Coagulant therapy.

METHOD OF COLLECTION OF DATA: A written informed consent was taken from all patients before their inclusion in the study. The study was approved by the ethical committee of the hospital.

Patients were randomly allocated to the two study groups using simple lots (25 in each group). Patients in one group underwent laparoscopic cholecystectomy while those in the other group underwent open cholecystectomy.

All the patients were kept nil by mouth overnight, prior to surgery and were given a dose of prophylactic antibiotic. All the patients were asked to evacuate bladder prior to surgery and a nasogastric tube was passed if thought to be necessary. All the surgeries were performed under general anesthesia, by the surgical team, consisting of consultants and residents.

Intra operative findings and post-operative data were all recorded and analyzed, using simple statistical tests like Chi square test and Z-test, to compare the results.

RESULTS:

DURATION OF SURGERY:
TABLE 1
               Open cholecystectomy       Laparoscopic
                                        cholecystectomy

60-90 min               9                      0
90-120 min              11                     8
120-150 min             5                      14
> 150 min               0                      3


Minimum time for open method: 70 min

Maximum time for open method: 130 min

Average time for open method: 90 min

Minimum time for laparoscopic method: 105 min

Maximum time for laparoscopic method: 170 min

Average time for laparoscopic method: 120 min

DURATION OF SURGERY:
Graph 1

TIME IN MINUTES

OPEN   90 min
LAP   120 min

TYPE OF SURGERY

Note: Table made from bar graph.


Average operating time for Open -90 min

Average operating Time for Lap-120 min

COMPLICATIONS:
TABLE 2A
INTRA OPERATIVE COMPLICATIONS:

Complications        Open    Laparoscopic

Bleeding               1          2
Bile duct injury      Nil        Nil
Bowel injury          Nil        Nil
Others                Nil        Nil


POST OPERATIVE COMPLICATIONS:
TABLE 2B

Complications                    Open    Laparoscopic

Bleeding                          Nil        Nil
Bile leak through drain           Nil         3
Wound infection                    2         Nil
Jaundice                          Nil        Nil
Post cholecystectomy syndrome     Nil         2
Pulmonary complications           Nil        Nil


INTRA OPERATIVE COMPLICATIONS:
TABLE 2C

Complications        Open (n = 25)   (%)    Lap (n = 25)    (%)

Bleeding                   1          4           2          8
Bile duct injury           0          0           0          0
Bowel injury               0          0           0          0
Others                     0          0           0          0
Total                      1          4%          2          8%


POST OPERATIVE COMPLICATIONS:
TABLE 2D

Complications                    Open(n=25)   (%)    Lap (n=25)   (%)

Bleeding                             0         0         0         0
Bile leak through drain              0         0         3         12
Wound infection                      2         8         0         0
Jaundice                             0         0         0         0
Post cholecystectomy syndrome        0         0         2         8
Pulmonary complications              0         0         0         0
Total                                2         8%        5        20%


CHI--SQUARE TEST:
TABLE 2E

Complications [n=50]         Open               Lap          Total
                       cholecystectomy    cholecystectomy

Intra operative               1                  2             3
Post- operative               2                  5             7
Total                       3 [6%]            7 [14%]          10
P = 0.023 significance between the        Chi-dist = 0.7822
variables


DURATION OF ANTIBIOTICS GIVEN:
TABLE 3

             Open cholecystectomy   Lap cholecystectomy

< 4 days              0                      19
4-6 days              8                      4
>6 days               17                     2


Minimum days of antibiotic for open method: 5 days

Maximum days of antibiotic for open method: 10 days

Average days of antibiotic for open method: 7 days

Minimum days of antibiotic for lap method: 3 days

Maximum days of antibiotic for lap method: 7 days

Average days of antibiotic for lap method: 4 days

DURATION OF ANTIBIOTICS GIVEN:
Graph 2

POST-OP DAYS

OPEN   7 days
LAP    4 days

TYPE OF SURGERY

Note: Table made from bar graph.


Average Post op antibiotics given for Open Method- 7 Days

Average Post op antibiotics given for Lap Method- 4 Days

POST OPERATIVE PAIN: Number of patients in whom analgesics required:
TABLE 4

Post                    Open               Lap
Operative Day     cholecystectomy    cholecystectomy

1                        25                 25
11                       25                 5
111                      20                 3
1V                       15                 --
V                        10                 --
V1                       5                  --


POST OPERATIVE PAIN:
Graph 3

POST-OPERATIVE  NO. OF PATIENTS
DAYS              LAP   OPEN

DAY 6              0     5
DAY 5              0    10
DAY 4              0    15
DAY 3              3    20
DAY 2              5    25
DAY 1             25    25

Note: Table made from bar graph.


Maximum days of analgesic for open method: 6 days

Maximum days of analgesic for lap method: 3 days

RESUMPTION OF NORMAL DIET:
TABLE 5
                   Open               Lap
             cholecystectomy    cholecystectomy

< 3 days            0                  19
3-4 days            10                 4
> 4 days            15                 2


Minimum resumption of normal diet for open: 3 days

Maximum resumption of normal diet for open: 7 days

Average resumption of normal diet for open: 5 days

Minimum resumption of normal diet for lap: 2 days

Maximum resumption of normal diet for lap: 5 days

Average resumption of normal diet for lap: 3 days

RESUMPTION OF NORMAL DIET:
Graph 4

POST-OPERATIVE

OPEN    5
LAP     3

Note: Table made from pie chart.


Average Post op resumption of normal diet for Open-5 Days

Average Post op resumption of normal diet for Lap-3 Days

HOSPITAL STAY:
TABLE 6

              Open cholecystectomy     Lap cholecystectomy

< 3 days                0                      20
3-5 days                7                       3
> 5 days               18                       2


Minimum post-op hospital stay for open: 4 days

Maximum post-op hospital stay for open: 10 days

Average post-op hospital stay for open: 7 days

Minimum post-op hospital stay for lap: 2 days

Maximum post-op hospital stay for lap: 7 days

Average post-op hospital stay for lap: 3 days

HOSPITAL STAY:
Graph 5

NO. OF DAYS

OPEN    7
LAP     3

Note: Table made from pie chart.


Average Post op hospital stay for open--10 Days

Average Post op hospital stay for open--5 Days

CONVERSION RATE: Conversion rate: Lap to Open [n = 25]
Graph 6

NO. OF DAYS

LAP,          92%
CONVERSION     8%
TO OPEN,

Note: Table made from pie chart.


CONVERSION TO OPEN METHOD: Procedure was converted to open method in two cases out of 25 patients due to the following reasons:

1. In one case there were plenty of thick adhesions between gallbladder and surrounding structures.

2. In another case there was excessive fat in the calot's triangle and cystic pedicle could not be identified.

Clinical details of patients subjected to laparoscopic or conventional cholecystectomy:
TABLE 7

Variables                  Lap cholecystectomy    Open cholecystectomy
                                 (n = 25)               (n = 25)

Age (years)                  42.76 +/- 12.09        39.12 +/- 13.79
Sex ratio (M/F) nos.              7/ 18                  11/ 14
Duration of surgery           120 +/- 10.80           90 +/- 13.84
  (min)
Analgesic requirement         3.12 +/- 0.33          6.08 +/- 0.40
  (days)
Antibiotic requirement        4.28 +/- 0.46          7.40 +/- 1.58
  (days)
Complications (%) [N=50]           14 %                   6 %
Resumption of normal          3.16 +/- 0.85          5.24 +/- 1.23
  diet (days)
Post-operative hospital       3.04 +/- 1.34          7.76 +/- 1.23
  stay (days)

Values are mean +/- S.D

P < 0.005


STATISTICAL ANALYSIS:

--The data are reported as the mean SD or the median (25thto75thpercentiles), depending on their distribution.

--The differences in quantitative variables between groups were assessed by means of the unpaired t test or the Mann-Whitney test.

--The chi-square test was used to assess differences in categoric variables between groups.

--Values of P< 0.005 were considered to be significant.

--All statistical analyses were performed using the SAS software.

DISCUSSION: A study of 25 open cholecystectomy patients of which 18 female and 7 male patients were compared with that of 25 cases of laparoscopic cholecystectomy of which 14 female and 11 male patients.

Duration of Procedure: In this study, the laparoscopic procedure was found to be associated with a longer operating time than open procedure (Median of 120 minutes for laparoscopic method against 90 minutes for open method). The more time required in LC was due to intra-operative gas leak, difficult adhesions, slippage of clips and delivery of gall bladder through the port site.

This is comparable with that of studies of Trondsenxand Porte. (2) Trondsendid a prospective randomized study to compare LC with OC (35 patients each). The results were that, LC took twice as long as OC (100 min v/s 50 min, p<0.01). Porte compared the results of 100 LC and 100 OC for cholelithiasis in elective surgery in a prospective age and sex matched cohort study and found that median operating time for LC [75, (40-180min)] was significantly longer than for OC [55, (20155min); p<0.001]. As experience is gained, the operating time is decreased. This "learning curve" represents adapting to operating in the 2-D screen, becoming familiar with the instrumentation and becoming accustomed to the technique. The surgeon gets trained in dealing with challenging cases in the course of his/ her learning curve.

Analgesia Requirement: Use of minimally invasive techniques in elective surgeries is associated with a reduced inflammatory stress response with improved pulmonary function and less hypoxia. (3,4) The VAS was significantly less for LC group (median 2days) compared to (median 4days) for OC group; p<0.005. Kum (5) also found a mean VAS score of 3.8 v/s 7.7 between LC and OC. There was more pain and more analgesics were required in patients in the OC group, especially when the patient developed wound infection.

The pain duration (median 2days for LC and median 4days for OC patients) and the duration of analgesics used (median 2days for LC and median 4days for OC patients) also were significantly less in LC group patients. This was due to the lesser incision size in LC. Other studies have also shown similar results. (6-11)

Complications Encountered: In this study, there were no major complications and had several minor ones. There was no peri-operative mortality and no CBD injury. The complications observed were bile leak (OC-0, LC-3), blood loss (OC-1, LC-2), wound infection (OC-2, LC-0) and post cholecystectomy syndrome (OC-0, LC-2) which were found to be comparable in both the groups.

Bile leak through drain tube in LC group was because of injury to the gall bladder bed in the liver during dissection. All the three patients were treated conservatively, drains were kept for a period of 2 days and the leak subsided. The main reason for blood loss in LC group was the slippage of the clip applied to the cystic artery and from the gall bladder bed.

There was no wound infection in LC group. 2 patients of OC group had wound infection, requiring regular dressing of the wounds, and the wounds healed over a period of 10 days. Wound infections were more commonly seen in the open group compared to laparoscopic group.

Harris (12) in his study found similar results, Bile leak (LC-2%, OC-1%), bleeding requiring transfusion (LC-1%, OC-2%) and wound infection rate (LC-0%, OC-1%). Other studies also reported similar results. (6, 2)

The conversion from laparoscopic procedure to open procedure was necessary in 2 patients out of 25. One patient required conversion due to difficult dissection in view of thick adhesions and the other due to excessive fat in calot's triangle. Conversion rate was 8%. Conversion rate was also found to be higher in acute cases in other studies (0-45%).13, 14 15

Post-operative recovery and Period of Hospitalization: The two most beneficial aspects of LC are the short hospital stay and the rapid recovery. (16) In this study, the median duration of hospital stay was 3days for LC group and 7days for OC group. The difference was found to be statistically significant (p<0.005). Hospital stay was more in OC group due to increased pain, wound infection, injectable antibiotics used and less mobilization due to pain. Porte (2), Trondsen (1) and Lujan (14) also found similar results. This was also confirmed in various other series. (6, 7 17 15 11 18)

The minimum resumption of normal diet for open method was 3 days compared to 2 days for laparoscopic method. The maximum resumption of normal diet for open method was 7 days due to wound infection, compared to 5 days for laparoscopic method following conversion. The mean resumption of normal diet for open method was 5 days compared to 3 days for laparoscopic method, suggesting the LC group returning to normal life earlier.

Patient Satisfaction: The OC group had larger wounds, which healed by primary intention with a big single scar. The LC group had port incisions of <1.5cm, wound healed by primary intention without much visible scar. Thus the cosmesis is the greatest advantage after laparoscopic cholecystectomy compared to open cholecystectomy.

CONCLUSION: In our study the laparoscopic cholecystectomy surpasses the open cholecystectomy by the following:

1. Post-operative recovery with quicker ambulance, better compliance and rapid return to normal activity with rapid resumption of normal diet.

2. Shorter duration of analgesic requirements.

3. Decreased wound infection.

4. Shorter post-operative hospital stay.

5. Best cosmesis with patient satisfaction.

The disadvantages in the laparoscopic procedure are the prolonged operative time, and the complications which can be minimized in due course of time as the learning curve progresses.

We have also found that the conversion to open cholecystectomy should be done in proper time without any hesitation in case of complications that could not be managed by laparoscopic surgery and conversion in such case reflects sound judgment and should not be considered as a complication.

DOI: 10.14260/jemds/2014/2400

REFERENCES:

(1.) Trondsen E, Riertsen O, Anderson OK, Kjaersgaard P. Laparoscopic and open cholecystectomy: A prospective randomized study. Eur J Surg 1993 Apr; 159(4): 217-21.

(2.) Porte RJ, De Vries BC. Laparoscopic versus open cholecystectomy: a prospective matchedcohort study. HPB Surg 1996; 9(2): 71-5.

(3.) Williams MD, Sulentich SM, Murr PC. Laparoscopic cholecystectomy produces less postoperative restriction of pulmonary function than open cholecystectomy. Surg Endosc 1993 Nov-Dec; 7(6): 489-92.

(4.) Farrow HC, Fletcher DR, Jones RM. The morbidity of surgical access: a study of open versus laparoscopic cholecystectomy. Aust NZJ Surg 1993 Dec; 63(12): 952-4.

(5.) Kum CK, Wong CW, Goh PM, Ti TK. Comparative study of pain level and analgesic requirement after laparoscopic and open cholecystectomy. Surg Laparosc Endosc 1994 Apr; 4(2): 139-41.

(6.) Hardy KJ, Miller H, Fletcher DR, Jones RM, Shulkes A, McNeil JJ. An evaluation of laparoscopic versus open cholecystectomy. Med J Aug 1994 Jan 17; 160(2): 58-62.

(7.) Chan HS, Ha XF, Ooi PJ, Mack P. A prospective comparative study between conventional and laparoscopic cholecystectomy. Singapore Med J 1995Aug; 36(4): 406-9.

(8.) Buanes T, Mjaland O. Complications in laparoscopic and open cholecystectomy: a prospective comparative trial. Surg Laparosc Endosc 1996 Aug; 6(4): 266-72.

(9.) de Pouvourville G, Reibet-Reinhat N, Fendrick M, Houry S, Testas P, Huguier M. A prospective comparison of costs and morbidity of laparoscopic versus open cholecystectomy. Hepatogastroenterology 1997 Jan-Feb; 44(13): 35-9.

(10.) Hendolin HI, Paakonen ME, Alhava EM, Tarvainen R, Kempinen T, Lahtinen P. Laparoscopic or open cholecystectomy: a prospective randomized trial to compare postoperative pain, pulmonary function and stress response. Eur J Surg 2000 May; 166(5): 394-9.

(11.) Schietroma M, Carlei F, Liakos C, Rossi M, Carloni A, Enang GN et al. Laparoscopic versus open cholecystectomy: An analysis of clinical and financial aspects. Panminerva Med 2001 Dec; 43(4): 239-42.

(12.) Harris BC. Retrospective comparison of outcome of 100 consecutive open cholecystectomies and 100 consecutive laparoscopic cholecystectomies. South Med J 1993 Sep; 86(9): 993-6.

(13.) Eldar S, Sabo E, Nash E, Abrahamson J, Matter I. Laparoscopic versus open cholecystectomy in acute cholecystitis. SurgLaparosc Endosc 1997 Oct; 7(5): 407-14.

(14.) Lujan JA, Parrilla P, Robles R, Marin P, Torralba JA, Garcia-Ayllon J. Laparoscopic versus open cholecystectomy in the treatment of acute cholecystitis: a prospective study. Arch Surg 1998 Feb; 133(2): 173-5.

(15.) Koperna T, Kisser M, Schulz F. Laparoscopic versus open treatment of patients with acute cholecystitis. Hepatogastroenterology 1999 Mar-Apr; 46(26): 753-7.

(16.) Attwood SE, Hill AD, Mealy K, Stephens RB. A prospective comparison of laparoscopic cholecystectomy versus open cholecystectomy. Ann R Coll Surg Engl 1992 Nov; 74(6): 397400.

(17.) al Hadi FH, Chiedozi LC, Salem MM, George TV, Desouky M, Pasha SM. Comparison of laparoscopic and open cholecystectomy at Prince Abdulrahman Al Sudairy Hospital; Saudi Arabia. East Afr Med J 1998 Sep; 75(9): 536-9.

(18.) Capizzi FD, Fogli L, Brulatti M, Boschi S, Di Domenico M, Papa V et al. Conversion rate in Laparoscopic cholecystectomy: evolution from 1993 and current state. J Laparoendosc Adv Surg Tech A 2003 Apr; 13(2): 89-91.

Anmol N [1], Lakshminarayan G [2], T.M. Manohar [3], Avadhani Geeta K [4], Abinash Hazarika [5]

AUTHORS:

[1.] Anmol N.

[2.] Lakshiminarayan G.

[3.] T. M. Manohar

[4.] AvadhaniGeeta K.

[5.] Abinash Hazarika

PARTICULARS OF CONTRIBUTORS:

[1.] Assistant Professor, Department of General Surgery, RGUHS, Bangalore.

[2.] Professor and Guide, Department of General Surgery, RGUHS, Bangalore.

[3.] Professor and Medical Superintendent, Department of General Surgery, RGUHS, Bangalore.

[4.] Professor and Unit Chief, Department of General Surgery, RGUHS, Bangalore.

[5.] Associate Professor, Department of General Surgery, RGUHS, Bangalore.

NAME ADDRESS EMAIL ID OF THE CORRESPONDING AUTHOR:

Dr. Anmol N, Assistant Professor, Department of General Surgery, AIMS, B. G. Nagara, Mandya--571448.

E-mail: anmolhsn@yahoo.co.in

Date of Submission: 18/02/2014.

Date of Peer Review: 19/02/2014.

Date of Acceptance: 22/03/2014.

Date of Publishing: 14/04/2014.
COPYRIGHT 2014 Akshantala Enterprises Private Limited
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2014 Gale, Cengage Learning. All rights reserved.

 
Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:ORIGINAL ARTICLE
Author:Anmol, N.; Lakshminarayan, G.; Manohar, T.M.; Avadhani, Geeta K.; Hazarika, Abinash
Publication:Journal of Evolution of Medical and Dental Sciences
Article Type:Report
Date:Apr 14, 2014
Words:3143
Previous Article:Spectrum of hepatic dysfunction in dengue fever.
Next Article:Transient cortical blindness in a 15 year old boy: a case report.
Topics:

Terms of use | Privacy policy | Copyright © 2018 Farlex, Inc. | Feedback | For webmasters