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Oncolytics Biotech granted Ras targeted herpes virus patent.

Oncolytics Biotech, Inc. (Calgary, Canada) announced that it has been granted United States Patent 6,649,157 entitled "Viruses for the Treatment of Cellular Proliferative Disorders." The claims in this patent cover the treatment of Ras mediated tumors using modified herpes viruses.

"We now have issued patents covering the treatment of cancers using three groups of viruses, including herpes, adenovirus and reovirus, that target the Ras pathway," said Dr. Matt Coffey, Vice President, Product Development of Oncolytics. "Herpes viruses having alterations in the (gamma)34.5 gene are commonly used in programs ranging from basic research to advanced clinical studies."

The issued claims in this patent cover the use of a herpes virus that has been modified by a mutation in the (gamma)34.5 gene, for the treatment of Ras mediated cancers. This is believed to cause this virus to provide specificity in Ras activated cancer cells.

Oncolytics is focused on the development of REOLYSIN, its proprietary formulation of the human reovirus, as a potential cancer therapeutic. Oncolytics' researchers have demonstrated that in vitro the reovirus is able to selectively kill human cancer cells that are derived from many types of cancer, including breast, prostate, pancreatic and brain tumors. They have also demonstrated successful results in a number of animal models. Phase I clinical trial results have indicated that REOLYSIN was well tolerated and that the reovirus demonstrated activity in tumors injected with REOLYSIN.

Oncolytics Biotech, Inc.

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Publication:BIOTECH Patent News
Article Type:Brief Article
Geographic Code:1CANA
Date:Nov 1, 2003
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