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Oncogenes and cancer aggressiveness.

Oncogenes and cancer aggressiveness

The fate of children with neuroblastoma, a cancer of the nervous system, can be gauged by looking at how many copies of the responsible oncogene, or cancer-causing gene, are present in their tumor cells, says Garrett M. Brodeur of Washington University in St. Louis. Collaborating with laboratories across the United States, Brodeur found that 68 percent of children whose tumor cells had only one copy of the oncogone were likely to have been spared disease progression after 18 months. This compared with a 30 percent figure in children with three to 10 copies and no children with more than 10 copies. The presence of mutiple gene copies may somehow increase the aggressiveness of the tumor, he says.
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Title Annotation:neuroblastoma
Author:Silberner, Joanne
Publication:Science News
Date:Apr 20, 1985
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