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OncoSec Medical doses first patient in TRIFECTA.

M2 EQUITYBITES-May 27, 2019-OncoSec Medical doses first patient in TRIFECTA


It was reported on Friday that OncoSec Medical, a late-stage cancer biotechnology company developing intratumoral gene-delivery immunotherapies, has dosed its first patient in its TRIFECTA triple combination clinical trial of OncoSec's TAVO, an IDO1 drug (epacadostat) and KEYTRUDA in patients with unresectable squamous cell carcinoma head and neck cancer.

Dr Chase Heaton, MD, an oncologic head and neck surgeon at UCSF, led the study in collaboration with Dr Alain Algazi, leader of the Head and Neck Medical Oncology Program at UCSF and Clinical Strategic Advisor to OncoSec. Preliminary data from the TRIFECTA study is expected later this year.

The triple combination of IL-12, IDO1 and anti-PD-1 monoclonal antibody is a first-of-its-kind clinical trial and aims to assess this three-way combination in squamous cell carcinoma head and neck cancer and to potentially expand testing to other tumour types if successful.

TRIFECTA is an investigator-initiated, single-arm, open-label clinical trial in which 35 evaluable unresectable squamous cell carcinoma head and neck cancer patients will receive TAVO, pembrolizumab, and epacadostat.

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Publication:M2 EquityBites (EQB)
Date:May 27, 2019
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