Novel Method Produces Highest-Ever Signals For hESC Detection.
SINGAPORE, September 26, 2018 -- Researchers here have developed a way to achieve an ultra-high bioelectric signal from human embryonic stem cells.
Using direct current-voltage methods and few-layered 2D molybdenum disulphide (MoS2) sheets, they produced cell signals two orders of magnitude higher than previous electrical-based detection methods.
This method can be combined with complementary metal-oxide-semiconductor circuits to produce a broadly applicable, fast and damage-free stem cell detection method to identify stem cell pluripotency.
Developed by researchers at Singapore University of Technology and Design (SUTD), the method can potentially ensure patient safety for future stem cell -based therapies, by enhancing native stem cell bioelectric signals.
Reliable methods to monitor and validate stem cell pluripotency are required to advance stem cell therapies and ensure patient safety.
Electrical-based detection (EBD) methods are non-invasive and can be used to detect stem cell pluripotency in real-time, and avoid the cost and cell-damaging issues caused by traditional detection methods.
However, past EBD methods have produced low current signals, preventing commercialization.
The research team achieved a 1.828 mA cell signal using direct current-voltage measurements and two-dimensional molybdenum disulphide sheets.
"Our method is able to enhance native stem cell signals feasible for commercialization to ensure therapeutic safety." said researcher Sophia S. Y. Chan.
The researchers also showed that the 2DMoS-2 sheets enhanced bioelectric signals without affecting the native characteristics of the stem cells.
From molecular dynamics (MD) simulations, the group deduced that the increased current flow was a result of the spontaneous interactions formed between the sheets and the cells.
Citation: Sophia S. Y. Chan et al., Ultra-High Signal Detection of Human Embryonic Stem Cells Driven by Two-Dimensional Materials. ACS Applied Bio Materials, 2018; 1 (2): 210 DOI: 10.1021/acsabm.8b00085
Contact: Desmond K. Loke,
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|Publication:||Stem Cell Research News|
|Date:||Oct 8, 2018|
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