Nosocomial pandemic (H1N1) 2009, United Kingdom, 2009-2010.
On June 11, 2009, the World Health Organization reported the first influenza pandemic of the 21st century (21,22). Although most cases of pandemic (H1N1) 2009 have been mild or subclinical, patients with severe disease have considerably affected hospital systems (23). Three nosocomial outbreaks of pandemic (H1N1) 2009 were reported in hemopoietic transplantation units and oncology wards. One outbreak was reportedly mild (24), and the other 2 involved aggressive illness, severe complications, and deaths (25,26).
In addition to outbreaks of nosocomial influenza, sporadic nosocomial influenza infections also occur but generally are not reported in the literature. We describe the clinical and epidemiologic characteristics of nosocomial pandemic (H1N1) 2009 infections during 2009-2010 in the United Kingdom that were identified during surveillance rather than through outbreak control activity.
During the pandemic (H1N1) 2009 outbreak in the United Kingdom, the Influenza Clinical Information Network (FLU-CIN) collected clinical and epidemiologic data for patients with virologically confirmed pandemic (H1N1) 2009 virus infection admitted to hospitals (27). Data included demography, symptoms, medical history, influenza vaccination history, relevant timelines, investigations and results, treatment (e.g., antiviral and antibacterial drugs), outcome, and cause of death when available. Trained health care workers abstracted data from case notes. During May 11, 2009-January 31, 2010, data were accrued from 75 National Health Service hospitals in 31 cities or towns in England, Scotland, Wales, and Northern Ireland.
From this source cohort, we defined patients with nosocomial pandemic (H1N1) 2009 as those admitted to a hospital for a reason other than acute respiratory infection in whom respiratory symptoms developed [greater than or equal to] 72 hours (3 days) after admission. In addition, we included infants who had not left the hospital since birth in whom pandemic (H1N1) 2009 had developed. We included transfers from other hospitals when a transfer was for a reason other than influenza and when the history of influenza clearly indicated that it had been acquired at another hospital. FLU-CIN procedures were reviewed and approved by the Ethics and Confidentiality Committee of the National Information Governance Board for Health and Social Care in England for collection, storage, and use of personal data for surveillance purposes.
Of 1,520 patients in the FLU-CIN cohort, illnesses in 30 (2.0%) (15 children) met the criteria for nosocomial influenza (Tables 1, 2 [adults] and Tables 3, 4 [children]). Patient ages ranged from 41 days to 76 years at onset of influenza symptoms (median age 44 years for adults and 1 year for children).
Concurrent Conditions and Reasons for Admission
Twelve (80%) adults and 14 (93%) children had serious underlying illnesses. The most common illnesses were hematologic malignancy for adults (5), and congenital abnormality or prematurity (7) or malignancy (4) for children.
Of the 15 adults, 2 had been admitted for elective surgical procedures; 1 for emergency surgery; and 8 for deterioration of chronic conditions, including complications caused by chemotherapy, malignancy, or transplantation. Two patients were admitted for pancreatitis (1 of whom had underlying myeloma); 1 patient was admitted for obstetric complications, and another patient was admitted for psoriasis. Of 15 children, 3 were admitted for elective procedures, 6 had been in the hospital since birth (because of prematurity or congenital abnormality), 1 was transferred from another hospital, and 5 had acute conditions (Table 2).
Pandemic Vaccination Status and Use of Antiviral and Antibacterial Drugs
None of the patients had received pandemic influenza vaccine. Although 14 adults were eligible because of concurrent conditions, influenza symptoms developed in 11 either before vaccine became available or before they would have seroconverted if vaccinated at the earliest opportunity (vaccine became available in the United Kingdom at the end of October 2009). Four children were eligible because of age and concurrent conditions, and symptoms developed in 3 before vaccine became available or before they would have seroconverted. Only 2 patients (both adults) had received seasonal influenza vaccine.
Twenty-one (72%) of 29 patients (10 children) received antiviral medication as inpatients (data were unknown for 1 patient); all initially received oseltamivir as monotherapy. Therapy for 2 patients (nos. 13 and 18) was switched from oseltamivir to zanamivir after 4 days and 10 days, respectively, because drug-resistant virus carrying the H275Y mutation was identified. Administration of antiviral drugs ranged from 0 to 8 days after symptom onset; 12 (57%) of 21 patients who received therapy did so within 48 hours. Sixteen patients were already receiving antibacterial drugs when influenza symptoms began. Two of these patients had a bacterial co-infection: coagulase-negative staphylococci in a blood culture for 1 patient and Pseudomonas aeruginosa in an unspecified intravenous line in 1 patient. Twelve patients received antibacterial drugs during their respiratory illness, 2 of whom had Haemophilus influenzae in sputum samples and 1 (coinfected with rhinovirus) who had had a blood culture positive for Klebsiella sp.
Signs and Symptoms
The most common signs were fever (8 [53%] adults and 12 [80%] children), cough (10, mostly adults), coryza (8, mostly children), and dyspnea (7). Fewer patients had malaise (4); myalgia (3); anorexia, nausea, diarrhea (2 each); and arthralgia, sore throat, headache, vomiting, altered consciousness, sneezing, and rash (a child) (1 each).
Course of Illness
Median length of hospitalization before onset of influenza symptoms was 11 days for adults (range 4-78 days) and 13 days (range 6-54 days) for children, excluding infants in a hospital since birth. For infants in a hospital since birth, the interval from birth to onset of influenza signs ranged from 41 to 123 days (median 78 days).
Results of chest radiography [less than or equal to] 3 days after onset of influenza symptoms were documented for 8 adults and 5 children (43%). Of these patients, 4 adults and 1 child (38%) had radiologically confirmed pneumonia.
Level 0 is care given to patients whose care needs can be met through normal ward care. Level 1 care is given to patients at risk for a deteriorating condition or recently relocated from higher levels of care whose needs can be met in an acute-care ward with additional advice and support from the critical-care team. Level 2 care is given to patients requiring more detailed observation or intervention, including support for a single failing organ system and those changing from higher levels of care (high dependency unit). Level 3 care is given to patients requiring advanced respiratory support alone or basic respiratory support and support for [greater than or equal to]2 organ systems. This level includes all patients with complex conditions requiring support for multiorgan failure (ICU).
Seven adults and 8 children (50%) required level 3 care (ICU, pediatric ICU, or neonatal ICU). One (3%)
adult required level 2 care. Six adults required mechanical ventilation and 1 required noninvasive ventilation (data for ventilatory support were unknown for 1 adult). Three children required mechanical ventilation and 1 required noninvasive ventilation. The remaining 4 children who received level 3 care were 3 infants and 1 child, each of whom required a period of close monitoring, but did not ultimately require ventilation. The remaining 7 adults and 7 children required level 0 or 1 care.
Outcomes and Mortality Rates
Five (33%) of 15 adults died in the acute-care hospital that provided treatment, 2 within 30 days after symptom onset. Of adults who died, 3 had underlying malignancy (1 noted to be terminal) or were immunocompromised and 2 had diabetes (type I and type II respectively). Pandemic (H1N1) 2009 was included in the recorded causes of death for all 5 adults. Although some patients had a prolonged hospital stay of [less than or equal to] 7 months, all remaining adults recovered from influenza and were discharged from the hospital.
Of 15 children, 3 (20%) were known to have died, although only 1 (a neonate with multiple congenital problems) died at the hospital where surveillance was conducted; acute respiratory distress syndrome/lower respiratory tract infection was stated as a cause of death. Another child, with malignancy, whose death was expected, died at home shortly after discharge. The third child was transferred to another hospital, and cause of death is unknown. All other children recovered from pandemic (H1N1) 2009. Two children remained in the hospital for treatment of their underlying malignancy, and the other children were discharged.
Although pandemic (H1N1) 2009 produced a generally mild illness, in the United Kingdom, as elsewhere, severe illness developed in a small proportion of relatively young patients who required hospitalization (28). Although nosocomial outbreaks of pandemic (H1N1) 2009 have been described, (24-26) sporadic nosocomial cases of pandemic (H1N1) 2009 identified during surveillance activities have not been described. The present case series has the advantage of being derived from a larger cohort of hospital inpatients in whom confirmation of pandemic (H1N1) 2009 was obtained by using nationally standardized PCR criteria, from settings where clinical management and infection control precautions were driven by national guidelines (29,30), and with data abstracted by trained nurses (27).
We based our definition of nosocomial influenza on a recent study of health care-associated influenza in children (31). A recent systematic review of incubation periods of acute respiratory viral infections found that the median incubation period for influenza was 1.4 days for influenza A, and symptoms developed in 95% of patients in [less than or equal to]2.8 days (32). These findings suggest that our cutoff point, 3 days after admission, make inclusion of community cases unlikely. In addition, in no patients did onset of respiratory illness occur <4 days after hospital admission; median length of hospitalization before symptom onset was 11 days for adults and 13 days for infants. Therefore, inadvertent inclusion of community-acquired cases is highly unlikely.
On the basis of information obtained in the study, we cannot determine where and from whom patients acquired influenza. However, 3 routes are possible. First, infection could have been acquired from other patients; 1 patient shared a bay with a patient who was presymptomatic at the time but for whom influenza was diagnosed 1 day later. Second, transmission from visitors of patients cannot be ruled out. Although national guidelines strongly discourage persons with influenza-like symptoms from visiting patients (29), this recommendation may have been difficult to implement, particularly for parents of sick children who often provide most hands-on care in a hospital. Third, transmission may have occurred from an infectious health care worker (because staff continue to work when infected with influenza ) or from contaminated hands of a health care worker. Transmission from asymptomatic persons might occur in all 3 instances (34).
Nosocomial cases in this study occurred equally in adults and children. Consistent with previous findings (3), most patients had [greater than or equal to]1 serious underlying illnesses, notably hematologic malignancies, congenital disorders, or prematurity. Staff and caregivers of patients with hematologic malignancy and prematurity are often particularly vigilant for symptoms suggestive of infectious disease. Although we detected nosocomial influenza in patients admitted to nonmedical areas (for emergency or elective surgery), many cases of nosocomial infection in other patient groups probably have been overlooked, particularly because influenza in these groups is likely to have been milder. Additionally, some patients are likely to have been discharged from a hospital during the incubation period of nosocomially acquired pandemic influenza. Thus, in this case series, detecting such patients would not have been possible.
More than half of patients required level 2 or level 3 care, which is higher than that required by the source cohort (12%) (27). Approximately one fifth of children and one third of adults died. Although the deaths of 2 patients were expected because of the stage of their underlying malignancy, this case-fatality rate is far higher than that for patients with pandemic (H1N1) 2009 and concurrent conditions in the source cohort (5%) (27). The combined factors of increased host susceptibility (18-20), prolonged virus shedding in immunocompromised children (35), and increased likelihood of development of drug resistance (36) raise questions about the need for enhanced infection control procedures in special-care-infant units, pediatric wards, and hemopoietic transplant units and a requirement that staff working in these areas be vaccinated (37-39). Precautions should include restricting unnecessary movement of patients to units with particularly vulnerable patients and postponement of semi-elective (nonurgent) procedures for hematology patients during peak pandemic activity.
Vaccine against pandemic (H1N1) 2009 became available at the end of October 2009. Assuming a 2-week period for vaccine administration, case-patients in groups at risk with influenza onset dates after November 30, 2009, could have been vaccinated and would have had time to seroconvert (14 days). Using these criteria, we determined that 4 cases (in 3 adults and 1 child) (13%) were potentially preventable by vaccination; 2 of these patients required escalated care, and 1 patient died. Although 72% of patients received antiviral therapy, similar to 75% in the source cohort (27), we observed avoidable delays between recording of respiratory symptoms and start of specific antiviral therapy in some adults and all children. Although under ordinary circumstances the complex clinical picture of such patients might result in delayed or incidental finding of influenza, in a pandemic situation or during a seasonal epidemic clinicians should be alert to the possibility of influenza. Delays encountered in this series most likely reflect a failure to consider such a diagnosis early. Other reasons are caution or uncertainty in using oseltamivir in patients younger than the drug licensing permits (12 months) in nonpandemic situations, reluctance to empirically instigate antiviral treatment in advance of a confirmed diagnosis of pandemic (H1N1) 2009, lack of confidence about absorption of oseltamivir by nasogastric tube insertion in patients already receiving mechanical ventilation or concerns about potential gastrointestinal side effects.
Nosocomial infections with pandemic (H1N1) 2009 in this case series were associated with high rates of illness and death. This finding highlights the need for adherence to infection control guidelines for staff and visitors (including the need to urge visitors not to visit when they are ill, particularly when providing hands-on care for vulnerable children), staff vaccination, maintenance of clinical suspicion for influenza in areas of high risk, prompt (empirical) antiviral treatment for vulnerable patients in whom influenza is possible or likely, and consideration of postponing nonurgent procedures for hematology patients during periods of known high influenza activity. This report demonstrates that nosocomial transmission is a recurrent problem when the prevalence of influenza is high and the total effect of nosocomial influenza is underestimated by outbreak reports alone.
We thank Alison Booth, Margaret Charlesworth, Sarah Rodenhurst, Angela Ballard, Alison Holmes, Sally Batham, Phayre Parkinson, Tracy Kumar, Aiden Dunphy, Anne Tunbridge, Patty Hempsall, Joyce Linskill, Aimee Turner, Eric Moulds, Elvina White, Sharon Grindle, Dawn Shevlin, Elaine Scott, Jennifer Cater, Erica Sergi, Helen Hill, Lorna Roche, Sarah Dyas, Maria Boswell, Gillian Vernon, Gillian Houghton, Heather Longworth, Angela Kerrigan, Sonia Greenwood, Gemma Thompson, Emily Jarvis, Tom Bewick, Charlotte Minter, Kristina Lum Kin, Jacqueline Daglish, Sam Hayton, Gemma Slinn, Michelle Lacey, Karen Duffy, and Anne Gordon for identifying cases and collating clinical data; Kevin Rooney, Brian Smyth, and Cathriona Kearns for identifying cases and facilitating data collection; Eleanor Anderson, Hilary Davison, William Carman, Mark Cotton, Arlene Reynolds, Heather Murdoch, Karen Voy, Rosie Hague, Ali McAllister, Teresa Cunningham, and Leslie Boydell for facilitating data collection; Ahmed Hashim, for performing data analysis; Alemayehu Amberbir, Safaa Al-Badri, Baraa Mahgoob, and Nachi Arunachalam for performing data entry and obtaining background population data; Gordon Duff and Janet Darbyshire for providing support and constructive comments; Shona Kelly for helping develop the initial data collection tool; Stephen Brett and Patrick O'Brien for assisting with further development of the dataset; and chief executive officers, clinicians, virologists, and managers for reporting cases to FLU-CIN.
This study was supported by the Department of Health, England, and the Scottish Government Chief Medical Officer and Public Health Directorate (support only for the center in Scotland).
Ms Enstone is research coordinator (influenza studies) in the Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK. Her research interests include influenza and health care-associated infections.
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Address for correspondence: Joanne E. Enstone, Epidemiology and Public Health, Clinical Sciences Building, University of Nottingham, Hucknall Rd, Nottingham NG5 1PB, UK; email: email@example.com
Joanne E. Enstone, Puja R. Myles, Peter J.M. Openshaw, Elaine M. Gadd, Wei Shen Lim, Malcolm G. Semple, Robert C. Read, Bruce L. Taylor, James McMenamin, Colin Armstrong, Barbara Bannister, Karl G. Nicholson, and Jonathan S. Nguyen-Van-Tam
Author affiliations: University of Nottingham, Nottingham, UK (J.E. Enstone, P.R. Myles, J.S. Nguyen-Van-Tam); Imperial College, London, UK (P.J.M. Openshaw); Department of Health, London (E.M. Gadd, C. Armstrong, B. Bannister); Nottingham University Hospitals National Health Service Trust, Nottingham (W.S. Lim); University of Liverpool, Liverpool, UK (M.G. Semple); University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK (R.C. Read); Portsmouth Hospitals National Health Service Trust, Portsmouth, UK (B.L. Taylor); Health Protection Scotland, Glasgow, Scotland (J. McMenamin); and University Hospitals of Leicester National Health Service Trust, Leicester, UK (K.G. Nicholson)
Table 1. Characteristics of 15 hospitalized adults with nosocomial pandemic (H1N1) 2009, United Kingdom, 2009-2010 Patient no. Age, y/sex Reason for admission 1 51/F Pancreatitis 2 44/M Transplant complications 3 34/M Emergency surgery 4 18/F Elective surgery 5 48/M Chemotherapy 6 43/M Pancreatitis 7 51/M Not recorded 8 39/F Metastatic soft tissue 9 76/M Elective surgery 10 45/F Not stated 11 44/F Psoriasis 12 22/M Posttransplant complications 13 52/M Elective procedure 14 33/F Obstetric complications 15 60/M Cerebrovascular disease Patient no. Main underlying illnesses 1 None recorded 2 Lymphoma 3 Diabetes 4 Neurodegenerative disease 5 Hematologic malignancy 6 Chronic liver disease 7 Lymphoma 8 Malignancy 9 Diabetes, heart disease 10 Myeloma 11 Psoriasis 12 Renal transplant, congenital abnormalities 13 Lymphocytic leukemia 14 None recorded 15 Diabetes, obesity Patient no. Signs and symptoms 1 Fever, unknown data in other fields 2 Productive cough, headache, coryza, myalgia 3 Unknown 4 Dyspnea, malaise 5 Fever, sore throat 6 Fever, malaise, myalgia 7 Fever, dry cough, diarrhea, myalgia, arthralgia 8 Dry cough, dyspnea 9 Productive cough, diarrhea, dyspnea 10 Fever, productive cough, nausea, anorexia, malaise 11 Fever, unknown data in other fields 12 Fever, cough, anorexia, malaise 13 Dyspnea, altered consciousness 14 Fever, productive cough 15 Unknown Table 2. Timelines and outcomes for 15 hospitalized adults with nosocomial pandemic (H1N1) 2009, United Kingdom, 2009-2010 Duration, d Symptom onset Hospital to receipt of admission to antiviral Patient no. Age, y/sex symptom onset therapy 1 51/F 26 0 2 44/M 14 0 3 34/M 8 0 4 18/F 4 Not given 5 48/M 9 4 6 43/M 5 0 7 51/M 29 0 8 39/F 5 3 9 76/M 11 Not given 10 45/F 24 2 11 44/F 14 Not given 12 22/M 5 0 13 52/M 78 1t 14 33/F 7 3 15 60/M 13 Not given Maximum Patient no. level of care * Outcomet 1 0/1 Unknown data 2 0/1 Recovered 3 3 Died 4 2 Transferred to other hospital 5 0/1 Recovered 6 0/1 Recovered 7 3 Died 8 0/1 Died 9 3 Died 10 0/1 Recovered 11 3 Transferred, improved 12 3 Died 13 3 Recovered 14 0/1 Recovered 15 3 Recovered * Level 0 care is given to patients whose care needs can be met through normal ward care. Level 1 care is given to patients at risk for a deteriorating condition or recently relocated from higher levels of care whose needs can be met in an acute-care ward with additional advice and support from the critical-care team. Level 3 care is given to patients requiring advanced respiratory support alone or basic respiratory support and support for >2 organ systems; this level includes all patients with complex conditions that required support for multiorgan failure (intensive care unit). Level 2 care is given to patients requiring more detailed observation or intervention, including support for a single failing organ system and those changing from higher levels of care (high dependency unit). ([dagger]) Deaths were attributed to pandemic (H1N1) 2009. ([double dagger]) Oseltamivir was replaced with zanamivir on day 5 because of identification of the H275Y drug-resistance mutation. Table 3. Characteristics of 15 hospitalized children with nosocomial pandemic (H1N1) 2009, United Kingdom, 2009-2010 Patient no. Age/sex Reason for admission 16 12 y/F Elective surgery 17 2 y/M Malignancy 18 4 y/F Bone marrow aspirate 19 15 y/M Ulcerative colitis 20 123 d/F Inpatient care from birth 21 1 y/F Laryngomalacia, transfer from tertiary care center 22 1 y/M Investigation 23 9 y/M Sepsis 24 12 y/M Anorexia 25 82 d/M Inpatient care from birth 26 64 d/M Inpatient care from birth 27 151 d/M Prematurity 28 101 d/F Inpatient care from birth 29 41 d/F Inpatient care from birth 30 9 y/F Elective surgery Patient no. Main underlying illnesses 16 Heart disease 17 Malignancy 18 Acute myeloid leukemia 19 Ulcerative colitis 20 Prematurity 21 Genetic disorder 22 Acute lymphoblastic leukemia 23 Cerebral palsy, septic pressure sore 24 Anorexia 25 Congenital abnormalities 26 Congenital abnormalities 27 Prematurity 28 Congenital abnormalities 29 Cystic fibrosis 30 Hematologic malignancy Patient no. Signs and symptoms 16 Fever, unknown data in other fields 17 Dry cough, coryza 18 Fever, productive cough 19 Fever, unknown data in other fields 20 Fever, dyspnea 21 Fever, dyspnea 22 Fever, dry cough, coryza 23 Fever, patient sedated and ventilated 24 Fever, coryza, nausea, sneezing 25 Coryza, dyspnoea 26 Fever, coryza 27 Fever, coryza 28 Fever, coryza 29 Fever, rash 30 Fever Table 4. Timelines and outcome for 15 hospitalized children with nosocomial pandemic (H1N1) 2009, United Kingdom, 2009-2010 Duration, d Hospital Symptom onset admission to to receipt of Patient no. Age/sex symptom onset antiviral therapy 16 12 y/F 10 Not given 17 2 y/M 24 Not given 18 4 y/F 54 2 ([dagger]) 19 15 y/M 11 8 20 123 d/F 123 (double Unknown data dagger]) 21 1 y/F 14 1 22 1 y/M 6 5 23 9 y/M Unknown 3 (transferred) 24 12 y/M 14 Not given 25 82 d/M 82t 1 26 64 d/M 64 (double Not given dagger]) 27 151 d/M 151 (double 3 dagger]) 28 101 d/F 101 (double 1 dagger]) 29 41 d/F 41 (double 1 dagger]) 30 9 y/F 12 1 Maximum Patient no. level of care * Outcome 16 3 Recovered 17 0/1 Died at home 18 0/1 Recovered 19 0/1 Recovered 20 3 Died after transfer to another hospital 21 0/1 Recovered 22 3 Recovered 23 3 Recovered 24 0/1 Recovered 25 3 Died ([section]) 26 1 Recovered 27 3 Recovered 28 3 Recovered 29 3 Recovered 30 0/1 Recovered * Level 3 care is given to patients requiring advanced respiratory support alone or basic respiratory support and support for [greater than or equal to]2 organ systems; this level includes all patients with complex conditions that required support for multiorgan failure (intensive care unit). Level 0 care is given to patients whose care needs can be met through normal ward care. Level 1 care is given to patients at risk for a deteriorating condition or recently relocated from higher levels of care whose needs can be met in an acute-care ward with additional advice and support from the critical-care team. ([double dagger]) Oseltamivir was replaced with zanamivir on day 11 because of identification of the H275Y drug-resistant mutation (patient also received acyclovir throughout hospitalization); ([double dagger]) Inpatient since birth. ([section]) Attributed to pandemic (H1N1) 2009.
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|Author:||Enstone, Joanne E.; Myles, Puja R.; Openshaw, Peter J.M.; Gadd, Elaine M.; Lim, Wei Shen; Semple, Ma|
|Publication:||Emerging Infectious Diseases|
|Date:||Apr 1, 2011|
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