Printer Friendly

New discovery may explain premature ageing.

Byline: ANI

Washington, Aug 7 (ANI): Scientists from Swedish medical university Karolinska Institutet claim to have identified the cause of premature ageing.

The normal ageing process has been linked to problems with cell respiration, the process through which the cells extract energy from nutrients.

The study showed that certain proteins that are synthesised in the cellular mitochondria - popularly known as the cells' power plants - become unstable and disintegrate, which in turn can impair cell respiration and cause premature ageing.

Problems with cell respiration have been linked to numerous conditions, from rare genetic diseases to diabetes, cancer, Parkinson's disease and the normal ageing process.

For cell respiration to function properly, it needs proteins synthesised outside and then imported into the mitochondria, and proteins synthesised within the mitochondria themselves from their own DNA (mtDNA).

It has long been known that an accumulation of harmful mutations of mtDNA can cause premature ageing.

The study involving mouse model revealed that changes in mtDNA can cause ageing by introducing errors into the proteins manufactured by the mitochondria.

The amount of protein is normal, but the proteins are rendered unstable and quickly disintegrate, leading eventually to the breakdown of cell respiration.

"Our results show that premature ageing is caused by point mutations in the mtDNA, which cause the mitochondrial proteins to become unstable and disintegrate," said Aleksandra Trifunovic, one of the scientists involved in the study.

The findings appear in journal Cell Metabolism. (ANI)

Copyright 2009 Asian News International (ANI) - All Rights Reserved.

Provided by an company
COPYRIGHT 2009 Al Bawaba (Middle East) Ltd.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2009 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:Asian News International
Date:Aug 7, 2009
Previous Article:Man nabbed over alleged death threats to Jay-Z, Beyonce.
Next Article:Stroke survivors at two-fold risk of hip or thigh fracture.

Related Articles
Scientists closer to creating elixir of youth.
Eternal youth is a fishy tale.

Terms of use | Privacy policy | Copyright © 2020 Farlex, Inc. | Feedback | For webmasters