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New NSAID risk with heart failure.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used by older adults to ease arthritis, but research has suggested they may increase the risk for heart attack and stroke. A study in the Jan. 26 issue of Archives of Internal Medicine reveals that their use by patients with chronic heart failure is associated with an increased risk of death and cardiovascular illness. Rofecoxib (Vioxx) and celecoxib (Celebrex), as well as ibuprofen (Advil), diclofenac (Cataflam), and naproxen (Aleve) were associated with a significantly increased risk of death among the 107,092 study subjects, who had a mean age of 75. NSAIDs have long been known to increase exacerbations of heart failure in those with this condition. Further research is required to establish the cardiovascular risk associated with all NSAIDs in subgroups of patients with cardiovascular disease, particularly to see whether a low dosage with analgesic effect can be used without increased risk. In the meantime, if you have established cardiovascular disease or increased cardiovascular risk, use these drugs with caution.

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Title Annotation:HEALTH UPDATE
Publication:Focus on Healthy Aging
Date:May 1, 2009
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