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New Essential Workbook for Organic Synthesis.

DUBLIN -- Research and Markets ( has announced the addition of "Workbook for Organic Synthesis: Strategy and Control" to their offering.

Workbook for Organic Synthesis: Strategy and Control - This workbook provides a comprehensive graded set of problems to illustrate and develop the themes of each of the chapters in the textbook Organic Synthesis: Strategy and Control. Each problem is followed by a fully explained solution and discussion. The examples extend the students' experience of the types of molecules being synthesised by organic chemists, and the strategies they employ to control their syntheses. By working through these examples students will develop their skills in analysing synthetic challenges, and build a toolkit of strategies for planning new syntheses. Together the workbook and textbook provide a complete course in advanced organic synthesis.

Organic Synthesis: Strategy and Control is a sequel to Stuart Warren's bestseller Organic Synthesis: The Disconnection Approach.

The Disconnection book concentrated on the planning behind the synthesis of compounds. This book focuses on putting the planning into practice. The two themes of the book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work.

The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. Interpenetrating this structure, the 36 chapters start with classic methods and progress to modern methods and modern strategic considerations. Heterocyclic chemistry is treated throughout the book with full mechanistic explanations as part of organic chemistry rather than a separate entity. Students and professional chemists familiar with Organic Synthesis:

The Disconnection Approach will enjoy the leap into a book designed for chemists at the coalface of organic synthesis.

Key Topics:

- Planning Organic Syntheses: Tactics, Strategy and Control

- Chemoselectivity

- Regioselectivity: Controlled Aldol Reactions

- Stereoselectivity: Stereoselective Aldol Reactions

- Alternative Strategies for Enone Synthesis

- Choosing a Strategy: The Synthesis of Cyclopentenones

- The Ortho Strategy for Aromatic Compounds

- s-Complexes of Metals

- Controlling the Michael Reaction

- Specific Enol Equivalents

- Extended Enolates

- Allyl Anions

- Homoenolates

- Acyl Anion Equivalents

- Synthesis of Double Bonds of Defined Stereochemistry

- Vinyl Anions

- Electrophilic Attack on Alkenes

- Vinyl Cations

- Allyl Alcohols: Allyl Cation Equivalents (and More)

- Control of Stereochemistry -- Introduction

- Diastereoselectivity

- Resolution

- The Chiral Pool: Asymmetric Synthesis with Natural Products as Starting Materials

- Asymmetric Induction I: Reagent-Based Strategy

- Asymmetric Induction II: Asymmetric Catalysis: Formation of C-O and C-N Bonds

- Asymmetric Induction III: Asymmetric Catalysis: Formation of C-H and C-C Bonds

- Asymmetric Induction IV: Substrate-Based Strategy

- Kinetic Resolution

- Enzymes: Biological Methods in Asymmetric Synthesis

- New Chiral Centres from Old: Enantiomerically Pure Compounds & Sophisticated Syntheses

- Strategy of Asymmetric Synthesis

- Functionalisation of Pyridine

- Oxidation of Aromatic Rings and of Enol(ate)s

- Functionality and Pericyclic Reactions: Nitrogen Heterocycles by Cycloadditions and Sigmatropic Rearrangements

- Synthesis and Chemistry of Azoles and other Heterocycles with Two or more Heteroatoms

- Tandem Organic Reactions

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Publication:Business Wire
Date:Apr 24, 2008
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