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Neuroprotective role of OLE.

Rabiei Z, Bigdeli M, Rasoulian B et al. 2012. The neuroprotection effect of pretreatment with olive leaf extract on brain lipidomics in rat stroke model. Phytomed 19:10;940-6.

Brain ischemia is profoundly debilitating, inducing the release of excitatory amino acids with subsequent receptor activation leading to calcium influx, metabolic and electrophysiological dysfunction and oxidative stress (including lipid peroxidation). Many phenomena observed during brain ischemia and reperfusion can be accounted for by damage to membrane lipids, specifically by lipolysis during ischemia and by radical mediated peroxidation of polyunsaturated fatty acids (PUFAs) during reperfusion.

Recent studies suggest that olive extracts suppress inflammation and reduce stress oxidative injury. Oleuropein reduces the amount of superoxide anions and hydroxyl radicals, and inhibits the respiratory burst of neutrophils and related radicals.

This animal study examined the effect of dietary olive leaf extract (OLE) on brain infarct volume, neurological dysfunction and brain lipidomics resulting from middle cerebral artery occlusion (MCAO) in rats.

Four main groups, each of12 male Wistar rats, received a dietary intervention (11-12.00 h daily) for 30 days. A control received gastric gavage with daily distilled water. The other three groups received 50 mg/kg/day, 75 mg/kg/ day, and 100 mg/kg/day gastric gavage of the OLE. Two hours after the last dose, each main group was subdivided to MCAO operated and intact subgroup for assessment of neuropathology (neurologic deficit scores and infarct volume), brain lipid analysis and brain glutathione levels respectively. After assessment the rats were sacrificed and their brain tissue examined.

Pre treatment with 75 mg/kg/day and 100 mg/kg per day OLE for 30 days resulted in a reduction of infarct volume, while the lower dose (50 mg/kg/day) had no effect. Pre treatment with 75 mg/kg/day and 100 mg/ kg/day OLE for 30 days also resulted in an increase of glutathione levels in cortex area (P = 0.01, P = 0.000 respectively) while the lower dose 50 mg/kg/day had no effect (P = 0.96). Glutathione is a main component in the antioxidant defences of a cell, acting to directly detoxify reactive oxygen species as well as acting as a substrate for several peroxidise.

The study concluded that pre treatment with dietary OLE may reduce infarct volume neurobehavioural deficit scores in an animal model of cerebral ischemia. The data suggests that alteration of brain lipidomics in ischemic reperfusion can have an impact on neuroprotection mechanism and is thus an important implication in the pathogenesis of stroke. Further research is warranted to investigate these observations.

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Title Annotation:olive leaf extract
Publication:Australian Journal of Herbal Medicine
Geographic Code:1USA
Date:Sep 1, 2012
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