Netherlands : Better insight into burden of disease of infectious diseases with DALY calculation.
By using the DALY Disability Adjusted Life Year calculation method, the burden of disease of different infectious diseases can be better compared with each other. Until now, the introduction of a new vaccine has looked at the burden of disease of an individual infectious disease based on the number of illnesses and deaths in the entire population and the severity for a person. The DALY method appears to be valuable in the assessment of adjustments in vaccination programs.
As an example, the RIVM National Institute for Public Health and the Environment looked at the disease burden of chickenpox in the Netherlands. Chickenpox is not (yet) included in the Dutch National Immunization Program. It turned out that the disease burden of this was lower than the disease burden of other infectious diseases such as rubella before this vaccination was introduced in the National vaccination program. Chickenpox and shingles are caused by the same virus. When looking at the combined disease burden of chickenpox and shingles together, the disease burden appears to be higher. This is still lower than for most other infectious diseases. The burden of disease for chickenpox and shingles together in the population is higher in 2017 than for rotavirus and meningococcal disease type B.
Fair comparison between diseases
Researchers at RIVM compared the burden of disease per patient and for the population as a whole with the disease burden of other infectious diseases with the DALY method ( disability adjusted life years ). The disease burden was chosen in the year before vaccination was introduced in the National Immunization Program or in 2017 for diseases that are not yet being vaccinated. The fact that this year differs per disease makes the interpretation more difficult, but gives the most honest comparison between the diseases themselves. With this calculation method it is better possible to assess the disease burden of an infectious disease in relation to the disease burden of other infectious diseases. This also makes setting priorities easier.
Figure: Mutual ratio of infectious diseases on the basis of the estimated disease burden a in the Netherlands per patient and for the population as a whole in the year before vaccination was introduced in the National Vaccination Program (black bulbs) or in 2017 for diseases not included in the National Vaccination Program ( White spheres).
a Expressed in disability-adjusted life years (DALYs)
Both axes are on a logarithmic scale; the size of the black (in RVP National Vaccination Program ) and white (not in RVP) bulbs is proportional to the number of estimated cases of illness; The gradient color from the lower left quadrant to the upper right quadrant indicates different levels of disease burden (yellow: relatively low disease burden at population and individual level (eg mumps) and red: relatively high disease burden at population and individual level (eg polio) ).
[c] 2019 Al Bawaba (Albawaba.com) Provided by SyndiGate Media Inc. ( Syndigate.info ).
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|Date:||May 15, 2019|
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