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Neoplasm rate argues for early colonoscopies.

SAN ANTONIO -- Patients with primary sclerosing cholangitis and inflammatory bowel disease were as likely to develop colon cancer within 2 years of diagnosis as they were within 8-10 years of diagnosis, based on data from 54 patients.

Yearly colonoscopies are often recommended for patients with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD), but the evidence to support early screening has been limited, said Dr. Erin Thackeray of the Mayo Clinic in Rochester, Minn.

In this study, the researchers reviewed medical charts from 54 adults with. PSC and IBD who were seen at the Mayo Clinic between 1995 and 2005 and were later diagnosed with colonic neoplasms. Average age at the time of colon cancer diagnosis was 51 years, and 70% of the patients were male.

The occurrence of colonic neoplasms per 100 patient-years of follow-up was 21.5 within 2 years, 20.5 at 2-4 years, 19.3 at 4-6 years, 16.8 at 6-8 years, and 20.4 at 8-10 years. Fourteen patients had colon cancer: two in the cecum, five in the ascending colon, four in the transverse colon, and three in the rectosigmoid colon.

The study was limited by its small size, but the results "support early and aggressive screening for colon cancer" in this patient population, said Dr. Thackeray, who noted she had no financial conflicts to disclose.


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Author:Splete, Heidi
Publication:Internal Medicine News
Article Type:Brief article
Geographic Code:1USA
Date:Dec 1, 2010
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