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Nanoparticles in fuel additives associated with liver damage.

Recent studies conducted at Marshall have demonstrated that nanoparticles of cerium oxide--common diesel fuel additives used to increase the fuel efficiency of automobile engines--can travel from the lungs to the liver and that this process is associated with liver damage.

The data in the study by Dr. Eric R. Blough and his colleagues at Marshall's Center for Diagnostic Nanosystems indicate there is a dose-dependent increase in the concentration of cerium in the liver of animals that had been exposed to the nanoparticles, which are only about 1/40,000 times as large as the width of a human hair. These increases in cerium were associated with elevations of liver enzymes in the blood and histological evidence consistent with liver damage. The research was published in the Oct. 13 issue of the peer-reviewed International Journal of Nanomedicine.

Cerium oxide is widely used as a polishing agent for glass mirrors, television tubes and ophthalmic lenses. Cerium oxide nanoparticles are used in the automobile industry to increase fuel efficiency and reduce particulate emissions. Some studies have found that cerium oxide nanoparticles may also be capable of acting as antioxidants, leading researchers to suggest these particles may also be useful for the treatment of cardiovascular disease, neurodegenerative disease and radiation-induced tissue damage.

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Title Annotation:Marshall University Joan C. Edwards School of Medicine NEWS
Publication:West Virginia Medical Journal
Article Type:Brief article
Geographic Code:1USA
Date:Jan 1, 2012
Words:210
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