Printer Friendly

NSAIDs and Alzheimer's disease.

Several recent studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) provide protection against the development of Alzheimer's disease (AD). A meta-analysis of these studies supports this idea. While aspirin use was associated with a 13% risk reduction, NSAID use was associated with a 28% risk reduction. Duration of use was another important factor; use for 2 years or longer was associated with a 73% risk reduction.

The exact mechanism of action of these drugs in preventing AD is unclear. Anti-inflammatory effects may provide protection, although it has been proposed that NSAIDs may bind to amyloid plaques. The decreased efficacy of aspirin may be related to the doses noted in the analysis; larger doses may be needed.

It is still to soon to recommend NSAIDs as a means to prevent dementia. However, many people will take NSAIDs anyway until further studies provide definitive evidence. A randomized controlled trial is under way. In the interim, nurses can counsel patients about the potential benefits of NSAID use in preventing AD, with clear explanation that further study is needed. Of note is that the meta-analysis showed no benefit whatsoever of NSAID use once AD is evident.

Etminan, M., Gill. S., & Samii. A. {2003). Effect of nonsteroidal anti-inflammatory drugs on risk of alzheimer's disease: Systematic review and meta-analysis of observational studies. British Medical Journal, 327, 128-31.
COPYRIGHT 2003 American Association of Neuroscience Nurses
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2003 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:Horizons
Publication:Journal of Neuroscience Nursing
Article Type:Brief Article
Date:Dec 1, 2003
Words:221
Previous Article:Bispectral index monitoring in the neurointensive care unit.
Next Article:Memantine for moderate to severe Alzheimer's disease.
Topics:


Related Articles
Alzheimer's disease: what we know now.
Alzheimer's disease.
What was that word?
NSAID use linked to lower incidence of Alzheimer's. (29% Lower Among Users).
Key clues differentiate Alzheimer's from Lewy body dementia.
Delaying dementia: drugs that fail as cures might still prevent Alzheimer's disease.
Predicting progression in Alzheimer's disease.
Take a walk: prevent Alzheimer's disease.
Alzheimer's and insulin resistance.

Terms of use | Privacy policy | Copyright © 2022 Farlex, Inc. | Feedback | For webmasters |