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NSAIDs, Alzheimer's risk. (Clinical Capsules).

Use of nonaspirin, nonsteroidal anti-inflammatory drugs is associated with a marginally decreased risk of developing Alzheimer's disease, reported Peter P. Zandi, Ph.D., of Johns Hopkins University, Baltimore, and his associates.

Among 83% of the residents of Cache County, Utah, over the age of 65 years, nonaspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) had a larger protective effect against Alzheimer's disease (AD) when users had taken the drug for more than 2 years but were not currently using it. Taking this study and two others into account, the investigators suggested "that sustained use of NSAIDs may delay or prevent AD only if they are taken during a critical window in the latent stages of the disease" (Neurology 59[6]:880-86, 2002).
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Author:Evans, Jeff
Publication:Clinical Psychiatry News
Date:Nov 1, 2002
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