Printer Friendly

Multifocal Pulmonary Granular Cell Tumor Presenting with Postobstructive Pneumonia.

1. Introduction

Granular cell tumor (GCT) is a rare lesion of Schwann cell origin which frequently occurs in the upper aerodigestive tract but can potentially affect all parts of the body, including the skin. The head and neck area is affected 45%-65% of the time with more than two-thirds of the lesions occurring intraorally--tongue, mucosa and hard palate being the most common sites [1]. Involvement of the bronchi and lower respiratory tract is much less common, with the lesions typically being solitary, submucosal origin nodules [2]. We present here the case of a rare large polypoid GCT causing postobstructive pneumonia.

2. Case

Our patient is a 59-year-old African American female with a past medical history of asthma who presented to the emergency department with shortness of breath, fever, and persistent right-sided chest pain with a cough productive of purulent sputum for the last 1 week. Physical examination was unremarkable except for crackles in the right lung base. Blood workup was significant for leukocytosis of 28,760/[mm.sup.3] (4.00-11.00 K/[mm.sup.3]), with normal hemoglobin level, platelet count, and chemistry panel. Chest X-ray (CXR) performed was significant for a right middle lobe consolidation. A subsequent CT chest showed a right middle lobe consolidation, with an endobronchial lesion within the right bronchus intermedius, concerning for postobstructive pneumonia (Figures 1 and 2). She was started on levofloxacin for treatment and admitted for further workup.

A bronchoscopy was performed which showed multiple flat white colored lesions in the trachea, left main-stem bronchi, right upper lobe bronchi (Figure 3), and a large polypoid, sessile, and white colored tumor located just distal to the secondary carina causing near-complete obstruction (>80%) of the right proximal bronchus intermedius (Figures 4 and 5). Several endobronchial biopsies were obtained from the large polypoid tumor located in bronchus intermedius and from the lesion in left main bronchus. Histopathological examination was consistent with granular cell tumor with tumor markers S-100 (Figure 6), Sox-10 (Figure 7), and CD-68 positive. Immunohistochemical analysis for pancytokeratin, cytokeratin 8/18, and synaptophysin was negative. Notably, sputum culture and right middle lobe bronchoalveolar lavage culture grew Streptococcus pneumoniae. The patient improved over the course of 4 days and was discharged home with a course of oral antibiotics for a total of 7 days, and follow-up was arranged in pulmonary clinic. However, patient was lost to follow-up.

3. Discussion

Granular cell tumors (GCTs), first described by Abrikosov in 1926 [3], are now believed to be of neurogenic (Schwann cell) origin [4]. Pulmonary GCTs comprise approximately 6-10% of all GCTs with majority being found in the lower respiratory tract as polypoid, endobronchial masses [2]. The tumor commonly occurs in middle-aged patients, with mean age reported to be in the fourth decade of life (36-37 years) and an equal prevalence in males and females [5]. Our patient is the oldest individual reported in literature, per our knowledge. Common symptoms at presentation include hemoptysis (17%), chronic cough (13%), chest pain (6%), and unexplained dyspnea (3%). Patients can also present with an asymptomatic lung nodule (8%) on imaging or as an incidental finding on bronchoscopy (8%) [6]. Our patient presented with multiple respiratory tract GCTs, including a large polypoid granular cell tumor causing postobstructive pneumonia with cultures positive for Streptococcus pneumoniae.

Pulmonary GCTs, like their extrapulmonary counterparts, can rarely be multifocal and have been reported to be associated with genetic mutations in PTPN11 as part of LEOPARD syndrome [2, 7]. In one case series, multifocal GCTs were reported to arise from all lobes of the lung and from the main-stem bronchi [2]. In up to 25% of cases there can be multiple GCTs, but the presence of multifocal GCT in lung does not necessarily indicate malignancy [2]. The presence of metastatic malignant GCT from extrapulmonary sites has been described in the settings of multifocal pulmonary GCT [8, 9] and metastasis should be ruled out. In our patient, despite the presence of multifocal GCT in the lungs, CT scan of chest abdomen and pelvis did not reveal any extrapulmonary focus of the disease decreasing suspicion for metastasis.

The infiltrative nature of pulmonary GCTs is a well-established feature for this benign tumor [2]. Peribronchial tissue extension has been reported in up to 40% of tumors as these tumors like to grow along muscle fibers, fibrous septa, and nerve sheath bundles [2]. Pseudoepitheliomatous hyperplasia, an overgrowth or thickening of the overlying squamous epithelium (Figure 8), is a diagnostic feature seen for these tumors. Microscopically, the tumor is composed of abundant eosinophilic granular cytoplasm, with fairly uniform arrangement of small nuclei. GCT is mostly benign, with malignant course occurring in 2% of cases [10]. Differentiation between benign and malignant GCTs is often difficult. Six histologic features have been described which can predict malignant potential of GCTs. These features include spindling of the tumor cells, the presence of vesicular nuclei with large nucleoli, increased mitotic rate (>2 mitoses/10 high-power fields at 200x magnification), a high nuclear-to-cytoplasm (N: C) ratio, pleomorphism, and necrosis. Histologically, malignant GCT is diagnosed when three or more of the six criteria are fulfilled [11]. Our case did not fulfill the criteria for malignant GCT.

Treatment of patients with endobronchial GCT has not been clearly defined. Current therapeutic options include surgical resection, endoscopic removal, YAG laser, and fulguration [2]. Overall, surgical excision has the highest cure rate. Of the 20 surgically treated patients followed for a mean of 3.3 years, only one patient was reported to have had symptomatic recurrence. The extent of surgical resection is unclear; however most authors agree that when postobstructive parenchymal damage has occurred, segmental or lobar resection is indicated [6]. Sleeve resection is considered when local resection of a mass is anatomically feasible [2]. The tumors can be observed in some cases. Spontaneous resolution has been documented in only one case. If distal lung parenchyma is preserved, then bronchoscopic extirpation and laser therapy can be considered [2].

GCT can be associated with other neoplasms in approximately 13% of cases [12]. The most common neoplasm associated with pulmonary GCT is lung carcinoma. Esophageal cancer and renal cell carcinomas have also been observed in patients with pulmonary GCT [2]. Nonneoplastic diseases reported in patients with pulmonary GCT include sarcoidosis and HIV infection [1,13].

In conclusion, pulmonary GCT is a rare entity, which can present as a large polypoid tumor causing recurrent postobstructive pneumonia and can be found throughout the bronchial tree and in peripheral lung fields in the form of multifocal GCTs, as in our case. Even though risk of malignancy is very rare, if multiple lung lesions are present, metastatic GCT should be ruled out by appropriate imaging. The patients should be followed at regular interval to assess for recurrence.

Disclosure

Dr. Doshi is the attending physician on record. This case was presented as a poster presentation at the American Thoracic Society International Conference held in Washington, DC, USA, in May 2017.

https://doi.org/10.1155/2017/8513702

Conflicts of Interest

The authors declare that they have no conflicts of interest.

References

[1] J. C. Garancis, R. A. Komorowski, and J. F. Kuzma, "Granular cell myoblastoma," Cancer, vol. 25, no. 3, pp. 542-550, 1970.

[2] M. Deavers, D. Guinee, M. N. Koss, and W. D. Travis, "Granular cell tumors of the lung: Clinicopathologic study of 20 cases," The American Journal of Surgical Pathology, vol. 19, no. 6, pp. 627-635, 1995.

[3] A. Abrikosov, "Ueber Myome ausgehend von quergestreifter willkurlicher Muskulatur," Virchows Archiv, 1926.

[4] A. M. Al-Ghamdi, J. D. A. Flint, N. L. Muller, and K. C. Stewart, "Hilar pulmonary granular cell tumor: A case report and review of the literature," Annals of Diagnostic Pathology, vol. 4, no. 4, pp. 245-251, 2000.

[5] E. Szczepulska-Wojcik, R. Langfort, W. Kupis et al., "Granular cell tumor - A rare, benign neoplasm of respiratory tract. Analysis ofcases diagnosed in institute of tuberculosis and lung diseases," Pneumonologia i Alergologia Polska, vol. 72, no. 5-6, pp. 187-191, 2004.

[6] O. G. Hernandez, E. F. Haponik, and W. R. Summer, "Granular cell tumour of the bronchus: Bronchoscopic and clinical features," Thorax, vol. 41, no. 12, pp. 927-931,1986.

[7] K. A. Schrader, T. N. Nelson, A. De Luca, D. G. Huntsman, and B. C. Mcgillivray, "Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11," Clinical Genetics, vol. 75, no. 2, pp. 185-189, 2009.

[8] M. Klima and J. Peters, "Malignant granular cell tumor," Archives of Pathology & Laboratory Medicine, vol. 111, no. 11, pp. 1070-1073,1987.

[9] J. W. Steffelaar, M. Nap, and V. U. J. G. M. Haelst, "Malignant granular cell tumor. Report of a case with special reference to carcinoembryonic antigen," The American Journal of Surgical Pathology, vol. 6, no. 7, pp. 665-672,1982.

[10] S. Aksoy, H. Abali, S. Kilickap, H. Harputluoglu, and M. Erman, "Metastatic granular cell tumor: A case report and review of the literature," Acta Oncologica, vol. 45, no. 1, pp. 91-94, 2006.

[11] M. Jiang, T. Anderson, C. Nwogu, and D. Tan, "Pulmonary malignant granular cell tumor," World Journal of Surgical Oncology, vol. 1, article 22, 2003.

[12] G. R. McSwain, R. Colpitts, A. Kreutner, P. H. O'Brien, and S. Spicer, "Granular cell myoblastoma," Surgery, Gynecology and Obstetrics, vol. 150, no. 5, pp. 703-710,1980.

[13] J. Liebman and C. M. Linthicum, "Granular cell myoblastoma (schwannoma) of the carina in a patient with sarcoidosis," Southern Medical Journal, vol. 69, no. 12, pp. 1613-1614, 1976.

Samid M. Farooqui, (1) Muhammad S. Khan, (1,2) Laura Adhikari, (3) and Viral Doshi (1,2)

(1) Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

(2) Section of Pulmonary, Critical Care and Sleep Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

(3) Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

Correspondence should be addressed to Samid M. Farooqui; samid-farooqui@ouhsc.edu

Received 17 May 2017; Accepted 17 September 2017; Published 15 October 2017

Academic Editor: Daniel T. Merrick

Caption: Figure 1

Caption: Figure 2

Caption: Figure 3

Caption: Figure 4

Caption: Figure 5

Caption: Figure 6

Caption: Figure 7

Caption: Figure 8
COPYRIGHT 2017 Hindawi Limited
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2017 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:Case Report
Author:Farooqui, Samid M.; Khan, Muhammad S.; Adhikari, Laura; Doshi, Viral
Publication:Case Reports in Pulmonology
Date:Jan 1, 2017
Words:1686
Previous Article:Orthodeoxia without Platypnea in Hereditary Hemorrhagic Telangiectasia in the Presence of a Cerebral Abscess and Multiple Pulmonary Arteriovenous...
Next Article:Daptomycin-Induced Acute Eosinophilic Pneumonia: Late Onset and Quick Recovery.
Topics:

Terms of use | Privacy policy | Copyright © 2022 Farlex, Inc. | Feedback | For webmasters |