Printer Friendly

Mother's blood shows baby's future.

In his masterwork "Auguries of Innocence," poet William Blake hailed the power of imaginative vision that beholds "a World in a Grain of Sand." Now researchers, in a tour de force of their own, have found a way to decipher the chromosomal makeup of a 10-week-old fetus by peering into a drop of its mother's blood.

The study was a small one, involving just two pregnant women-one who feared that her baby might be born with sickle-cell anemia and another who worried that her baby might inherit a hemoglobin deficiency called thalassemia. Both fetuses were normal. Despite the study's limitations, the implications for prenatal diagnosis of genetic disease are profound, asserts Yuet Wai Kan of the Howard Hughes Medical Institute at the University of California, San Francisco. "The method could be applied to any genetic disease in which the mutation is known," he says. Kan and his colleagues report their findings in the November Nature Genetics. David L. Rimoin of the University of California, Los Angeles, School of Medicine says that such a test, if it lives up to expectations, could usher in a new era of prenatal diagnosis. "One can theorize, at least, that you could develop microchips with hundreds of mutations on them and screen for all of the mutations," he says.

Just 30 years ago, prenatal diagnosis did not exist. Now, amniocentesis and chorionic villus sampling can tell expectant parents whether their child will be born with sickle-cell anemia, thalassemia, or certain other genetic diseases. Parents can then decide whether to continue the pregnancy. These diagnostic procedures carry slight risks because they require doctors to invade the uterus with a slender needle to obtain fetal cells. Amniocentesis provokes miscarriage in a fraction of 1 percent of cases. Chorionic villus sampling causes miscarriage about 1 percent of the time. Using maternal blood would eliminate those risks, Rimoin says. The Kan study was inspired, in part, by research showing that fetal cells circulate in a mother's blood. Indeed, scientists showed recently that lymphocytes descended from a fetus' white blood cells may flourish in the mother's blood for decades (SN: 2/10/96, p. 85). Although the presence of fetal cells in a woman's bloodstream makes the new technique possible, the ability of the cells to replicate long after a baby's birth also means that doctors might recover cells stemming from an earlier pregnancy. To eliminate this possibility, the researchers zeroed in on a red blood cell, called an erythroblast, that has a brief life span. First, they sorted out maternal and fetal red cells from all others by mixing them with iron-bearing beads that had been coated with antibodies. These antibodies attached themselves to the red cells. The group then used a magnet to pull the beads laden with red cells from the maternal blood. Next, the researchers washed the red cells off the beads and mixed them with antibodies to fetal hemoglobin. These antibodies, which had been tagged with an intense red dye, latched onto the fetal cells and stained them a brilliant scarlet. Then came the painstaking task of picking out each dyed fetal cell from the thousands of other cells under a microscope. Once this task was complete, the researchers analyzed the fetal cells' DNA to determine whether the threatening mutations were present. Kan says he and his coworkers will test the technique in more patients to assess its reliability. Then, he predicts, other researchers will computerize the process to hasten it along. Finally, perhaps, a new era of prenatal diagnosis will be born. -
COPYRIGHT 1996 Science Service, Inc.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 1996, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:genetic makeup of fetus found in mother's blood
Author:Sternberg, Steve
Publication:Science News
Date:Nov 2, 1996
Previous Article:Sculptures of light: a new three-dimensional display turns on the imagination.
Next Article:Jolting crystals into nanostructures.

Related Articles
Broader screening for hepatitis B.
Birth defects jump when mom needs insulin.
Fetal repair: safe for mom, chancy for child.
Smoke gets in your cervix and fetus.
Prenatal Diagnosis Using Mother's Blood.
Blood test for predicting pregnancy problems. (Preeclampsia Progress).
Inflammation in womb tied to cerebral palsy.
Womb pollution?
Flu, fetuses, and schizophrenia.

Terms of use | Privacy policy | Copyright © 2021 Farlex, Inc. | Feedback | For webmasters