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Mortality rates higher in diabetics using diuretics.

Mortality Higher in Diabetics Using Diuretics

Diabetics who are treated for hypertension with diuretics may be at increased risk for cardiovascular mortality, reports Lori M.B. Laffel, MD. In a prospective study, she and colleagues examined data from the Diabetic Retinopathy Study (1972 to 1979), in which 1,217 diabetics received medical examinations at entry and at annual visits. Cardiovascular mortality was significantly lower among diabetics who wre free of proteinuria and remained low regardless of blood pressure or drug treatment.

Among patients with proteinuria, however, treatment with any type of antihypertensive agent -- and especially diuretics -- was the most significant predictor of mortality. "Patients with proteinuria who were treated with diuretics had a mortality rate of 0.104, compared with a rate of .024 in those who were not treated," notes Dr. Laffel.

Further study is needed to identify the mechanism of increased mortality, she says. Dr. Laffel is staff physician, Joslin Diabetes Center, Boston.
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Publication:Nutrition Health Review
Date:Mar 22, 1990
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