Monsanto Technology LLC (St. Louis, MO) has patented a method to
isolate disease resistance genes in plants. The method teaches to
transiently express in susceptible plants large numbers of R-gene
homologs or non-host inducible genes isolated from non-host resistant
plants. These plants can be screened for either disease resistance or
ability to respond with a hypersensitive response to pathogen-elicitor
subjection. The invention also reports several R-genes and non-host
inducible genes that have been successfully isolated using the described
method. These R-genes trigger a hypersensitive response in tobacco that
is dependent on the presence of the ubiquitous P. infestans elicitor
INF1. The presented R-genes are predicted to be both the first R-genes
isolated that confer resistance against P. infestans and the first
R-genes involved in non-host resistance. (US 6,544,733)
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