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Molecular neurosurgery with targeted toxins.


Molecular neurosurgery with targeted toxins.

Ed. by Ronald G. Wiley and Douglas A. Lappi.

Humana Press Inc.


311 pages




Targeted cytotoxins are used in experimental neurobiology to produce neural lesions of unprecedented selectivity to match the complexity of the organization of the nervous system itself. Researchers in the neurosciences, psychology, pharmaceuticals, and other specialties introduce the considerations and background of the toxins, then describe examples of using the immunotoxin 192 IgG-saporin to make lesions on the cholinergic basal forebrain, the anti-DBH-saporin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin to produce narcoleptic animals, a variety of saporin conjugates in pain research, and cholera toxin B chain- saporin to produce a model of CNS dymyelination.

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Publication:SciTech Book News
Article Type:Book Review
Date:Sep 1, 2005
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