Minimum inhibitory concentration of adherence of Punica granatum Linn (pomegranate) gel against S. mutans, S. mitis and C. albicans.
The purpose of this study was to investigate the antimicrobial
effect of a Punica granatum Linn (pomegranate) phytotherapeutic gel and
miconazole (Daktarin oral gel) against three standard streptococci strains (mutans ATCC 25175, sanguis ATCC 10577 and mitis ATCC 9811), S.
mutans clinically isolated and Candida albicans either alone or in
association. The effect of minimum inhibitory concentrations of the gels
on the adherence of these microorganisms to glass was assessed in the
presence of 5% sucrose, using increasing and doubled concentrations of
the diluted solution of the gels ranging from 1:1 to 1:1024. The minimum
inhibitory concentrations of adherence of Punica granatum L. gel against
the test organisms were: 1:16 for S. mutans (ATCC), S. mutans (CI) and
S. sanguis; 1:128 for S. mitis and 1:64 for C. albicans. The minimum
inhibitory concentrations of adherence of miconazole against the same
organisms were: 1:512, 1:64, 1:4, 1:128 and 1:16, respectively. In
experiments with three and four associated microorganisms, the Punica
granatum L. gel had greater efficiency in inhibiting microbial adherence
than the miconazole. The results of this study suggest that this
phytotherapeutic agent might be used in the control of adherence of
different microorganisms in the oral cavity.
Braz Dent J. 2006;17(3):223-7