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Mieloencefalopatia degenerativa progressiva hereditaria (Sindrome da Oscilacao) em bezerros Gir.

Degenerative progressive hereditary mieloencefalopathy (Weaver Syndrome) in Gir calves

INTRODUCTION

The degenerative progressive hereditary mieloencefalopathy, also known as "weaver syndrome" (RADOSTITS et al., 2002b), is a hereditary defect that is described as occurring in Brown Swiss cattle (GEORGES et al., 1993; RADOSTITS et al., 2002b). Males are more commonly affected than females. It is expected that, for 100,000 Brown Swiss bovines registered in the United States, 563 cases of the disease occur (STUART & LEIPOLD, 1985). In these animals, the disease occurs in cattle between six months and two years old and, occasionally, later. The main clinical signs are ataxia, progressive weakness of the pelvic limbs, difficulties to stand up, proprioceptive deficit and oscillatory hypermetric walking (GEORGES et al., 1993; RADOSTITS et al., 2002b). The mental state is always alert and all the reflexes are always present and normal. The case progresses to sternal recumbency after 18 to 36 months of evolution, although the appetite and thirst remain normal (LEIPOLD et al., 1973; STUART & LEIPOLD, 1983). Failure in the spermatogenesis and ovarian functions were also described (STUART & LEIPOLD, 1983). Mostly, death does not come spontaneously by the injuries of the disease, and after months of evolution, the euthanasia is indicated (RADOSTITS et al., 2002b). Some animals may die due to the long time of recumbency or rumenal meteorism (GEORGES et al., 1993). At the necropsy, axonal degeneration with formation of spheroids and vacuolation in the cerebellar white matter and in the spinal cord, mainly in the thoracic segment, were observed (AITCHISON et al., 1985; STUART & LEIPOLD, 1985). An ultrastructural study revealed reduction of synaptic junction densities in the affected animals, indicating lesions in neurotransmitters liberation, dysfunction of the terminal synaptic plates, or lost of the motor cortex specific cells. There is no muscle alteration, although neurogenic atrophy may occur (AITCHISON et al., 1985). The disease is chromosomal, and it is believed that it is related to the high milk production (GEORGE, 2002), and may be identified by the examination of the chromosomes (GEORGES et al., 1993). A similar disease has been described in the Murray Grey cattle (EDWARDS et al., 1988).

MATERIAL AND METHODS

Two Zebu Gir calves, one male and one female, sons of the same bull but of different cows, about two months old, white and yellow skin, were examined at the Hospital of the Veterinary College, from the University of Uberaba--UNIUBE--Uberaba, MG / Brazil, both with balance deficits and difficulties to stand up. The clinical examination followed what is recommended by RADOSTITS et al. (2002a). The nervous system was examined by evaluation of the mental attitude, gait, head and limbs posture, cranial nerves, sensitivity for superficial and deep pain and evaluation of the spinal reflexes, as recommended by BORGES (2004). The hematological parameters and cerebrospinal fluid were analyzed and evaluated as the techniques recommended for the bovine species by JAIN (1993) and FEITOSA (2004b), respectively.

RESULTS

The clinical history revealed that every year one or two calves were born normal and, some days later, they got ill showing loss of balance and difficulties to move the pelvic limbs, falls and evolution to sternal recumbency. The animals were always alert and had normal appetite and thirst. Along the years, at the farm, always after a few months all the sick animals were sacrificed.

The calves, presented for examination, had so far twenty days of disease evolution, with identical clinical signs to those that were born in the past years. The first signs were balance loss of the pelvic limbs, hypermetric walk, head tremor, tendency to lay down in sternal recumbency and slow and progressive evolution. They were treated by their owner with unknown amounts of vitamins and penicillin.

At general clinical examinations, the animals were in good state of health, docile and were in sternal recumbency. The rectal temperature, heart and respiratory rates were within normal values, according to FEITOSA (2004a).

The neurological examination has shown that they were mentally alert, had appropriate conscience, head tremor, normal reflexes, normal sensitivity for superficial and deep pain, sensitive motor deficit of the pelvic limbs, with a severe ataxia which led to falls, and turned the animals unable to stand up for a period of time over a few seconds (Figure 1).

The standard hematological (JAIN, 1993) and cerebrospinal fluid (FEITOSA, 2004b) parameters had normal values for the bovine species and are shown on tables 1 and 2.

The male calf was designated to the euthanasia and necroscopic examination. The female calf was kept under observation for 15 days. During this time, the clinical picture has constantly deteriorated, and the sacrifice was also indicated.

At the necropsy, done by the technique described by JONES & GLEISER (1954) and BAKER & ALVARADO (1969), a large amount of cerebrospinal fluid was seen and the cerebellum matter was softer than usual. The histological examination revealed vacuolation of the white matter of the cerebellum and axonal degeneration (Figure 2). No other lesion was found.

DISCUSSION

The literature does not describe neurological alterations, in Gir cattle, or in any other Zebu cattle, compatible to those observed in these calves, although, many neuropathies are described in taurine breed calves, mostly, an abiotrophy coming from an autossomic recessive disease (GEORGE, 2002).

Some nervous system hereditary defects described in taurine breed calves could be considered in the differential diagnosis for the calves in this report, because they lead to clinical signs similar to the degenerative progressive hereditary mieloencefalopathy. These defects are: mannosidosis, rejected by causing deformity at the skull and face (JOLLY, 1993); gangliosidosis, but the signs of this disease should include absence of response to external stimulus and slow mastication and deglutition (JOLLY, 1993); cerebellar abiotrophy, but the histological findings include loss of the Purkinge cells (DE LAHUNTA, 1990); hereditary neurodegeneration, but it is a recessive mutation linked to the sex, occurring only on males (GEORGE, 2002); calves's hereditary ataxia, but histological examination reveals aplasia of the cerebellum neurons (GEORGE, 2002).

[FIGURE 1 OMITTED]

On the other hand, LEIPOLD et al. (1973), STUART & LEIPOLD (1983), GEORGES et al. (1993) and RADOSTITS et al. (2002b) reported Brown Swiss calves showing clinical signs very similar to the Gir calves in this report (Figure 1). And, at the Gir calves's necropsy, vacuolation of the white matter of the cerebellum and axonal degeneration were found (Figure 2), exactly the same described by AITCHISON et al. (1985) and STUART & LEIPOLD (1985), which was axonal degeneration with formation of spheroids and vacuolation in the cerebellar white matter and in the spinal cord.

[FIGURE 2 OMITTED]

Therefore, despite the degenerative progressive hereditary mieloencefalopathy is a very well known disease in Brown Swiss calves, the similarity of the clinical and pathological signs allows to consider that this disease may also occur on Gir calves.

CONCLUSION

Based on the clinical and pathological findings, also macro and microscopic, it can be suggested that the neuropathy described is very similar to the degenerative progressive hereditary mieloencefalopathy, observed on Brown Swiss calves.

Received 12.30.05 Approved 05.02.07

REFERENCES

AITCHISON, C.S. et al. Ultrastructural alterations of motor cortex synaptic junctions in Brown Swiss cattle with weaver syndrome. Am J Vet Res, v.46, p.1733-1736, 1985.

BAKER, R.D.; ALVARADO, D.M. Tecnicas de necropsia. Mexico: Interamericana, 1969. 109p.

BORGES, A.S. Semiologia do sistema nervoso de grandes animais. In: FEITOSA, F.L.F. Semiologia veterinaria--A arte do diagnostico. Sao Paulo: Roca, 2004. Cap.10, p.506-526.

DE LAHUNTA, A. Abiotrophy in animals, a review. Am J Vet Res, v.54, p.65-76, 1990.

EDWARDS, J.R. et al. Inherited spinal myelinopathy in Murray Gray cattle. Aust Vet J, v.65, p.108-109, 1988.

FEITOSA, F.L.F. Semiologia veterinaria--A arte do diagnostico. Sao Paulo: Roca, 2004a. 807p.

FEITOSA, M.M. Exames complementares. In: FEITOSA, F.L.F. Semiologia veterinaria--A arte do diagnostico. Sao Paulo: Roca: 2004b. Cap. 10, p.527-546.

GEORGE, L.W. Molestias do sistema nervoso. In: SMITH, B.P. Tratado de medicina interna de grandes animais. Sao Paulo: Manole, 2002. Cap.33, p.901-1040.

GEORGES, M. et al. Microsatellite mapping of the gene weaver disease in cattle will allow the study of an associated quantitative trait locus. Proc Natl Acad Sci, v.90, p.1058-1062, 1993.

JAIN, N.C. Essentials of veterinary hematology. 5.ed. Philadelphia: Lea & Febiger, 1993. 417p.

JOLLY, R.D. Lysosomal storage diseases in livestock. Vet Clin North Am: Food Animal Pract, v.9, p.41-53, 1993.

JONES, T.C.; GLEISER, C.A. Veterinary necropsy procedures. Philadelphia: Leppincott, 1954. 136p.

LEIPOLD, H.W. et al. Weaver syndrome in Brown Swiss cattle: clinical signs and pathology. Vet Med Small Anim Clin, v.68, p.645-647, 1973.

RADOSTITS, O.M. Exame clinico de bovinos adultos e bezerros. In--. RADOSTITS, O.M. et al. Exame clinico e diagnostico em veterinaria. Rio de Janeiro: Guanabara Koogan, 2002a. p.118-139.

RADOSTITS, O.M. et al. Doencas causadas pela heranca de caracteres indesejaveis. In: RADOSTITS, O.M. Clinica veterinaria--Um tratado de de doencas de bovinos, ovinos, suinos, caprinos e equinos. Rio de Janeiro: Roca, 2002b. Cap.30, p.1561-1593.

STUART, L.D.; LEIPOLD, H.W. Bovine progressive degenerative myeloencephalopathy "weaver" of Brown Swiss cattle II. Clinical and laboratory findings. Bovine Pract, v.18, p.133-146, 1983.

STUART, L.D.; LEIPOLD, H.W. Lesions in bovine progressive degenerative myeloencephalopathy "weaver" of Brown Swiss cattle I. Vet Pathol, v.22, p.13-23, 1985.

Pedro Carlos Lucas de Oliveira (I) * Humberto Eustaquio Coelho (I) Alessandra Aparecida de Medeiros (I) Susana Elisa Rieck (I) Juliana Meirelles de Souza (I) Rodrigo Rodrigues Alvarenga (I)

(I) Hospital Veterinario de Uberaba, Faculdade de Veterinaria, Universidade de Uberaba. Rua Bahia, no 870, Bairro Santa Maria, 38050-130, Uberaba, MG, Brasil. E-mail: pedrolucaso@uol.com.br. * Autor para correspondencia.
Table 1 - Hematological parameters observed on two Gir calves with
a weaver syndrome like condition.

Parameter            Male calf            Female calf

Erythrocytes         7.44 x [10.sup.3]    10.00 x [10.sup.3]
Hemoglobin           8                    9.8
Globular volume      29                   31
Plasmatic protein    7                    7.5
Fibrinogen           500                  300
Platelets            189 x [10.sup.3]     211 x [10.sup.3]
Leukocytes           11,600               10,700
Neutrophils          3,308                3,531
Lymphocytes          7,794                6,955
Monocytes            498                  214

Parameter            Normal value

Erythrocytes         5 - 10 x [10.sup.3]/[mm.sup.3]
Hemoglobin           8 - 15 g%
Globular volume      24 - 46 %
Plasmatic protein    7 - 8.5 g/dL
Fibrinogen           300 - 700 mg/dL
Platelets            100 - 800 x [10.sup.3]/[mm.sup.3]
Leukocytes           4,000 - 12,000 / [mm.sup.3]
Neutrophils          600 - 4,000 / [mm.sup.3]
Lymphocytes          2,500 - 7,500 / [mm.sup.3]
Monocytes            25 - 840 / [mm.sup.3]

OBS: other kinds of blood cells not found in this table were never
identified in the exams.

Table 2 - Cerebrospinal fluid parameters observed on two Gir
calves with a weaver syndrome like condition.

Parameter         Male calf     Female calf    Normal value

Volume            2             4              variable
Color             uncolored     uncolored      uncolored
Odor              Sui generis   Sui generis    Sui generis
Aspect            Limpid        Limpid         Limpid
Density           1005          1006           1006 - 1012
Protein           17            22             10 - 40 mg/dL
Blood presence    absent        absent         absent
pH                8             8              9-Jul
Glucose           65            84             50 - 90 mg/dL
Pandhy            negative      negative       negative
Blood cells       absent        absent         absent
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Author:Lucas de Oliveira, Pedro Carlos; Eustaquio Coelho, Humberto; Aparecida de Medeiros, Alessandra; Riec
Publication:Ciencia Rural
Date:Jan 1, 2008
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