Mercury may boost MI risk. (Clinical Capsules).
In an international case-control study, mercury levels in toenail clippings and adipose tissue were assessed in 684 European men within 24 hours of a first myocardial infarction and in 724 control subjects without MI. Mercury levels in the patients were 15% higher than those in controls, after adjustment for cardiovascular risk factors. A strong dose-response pattern was seen, with a 2.16 odds ratio for MI in patients in the highest quintile of mercury levels, compared with those in the lowest quintile (N. Engl. J. Med. 347:1747-54, 2002).
"Fish intake is currently recommended to reduce the risk of cardiovascular disease and as part of a Mediterranean-type diet," the investigators noted. But epidemiologic data on "fish intake or fish-oil levels and coronary heart disease are contradictory, ranging from clearly inverse associations to virtually null associations and to positive associations."
The findings imply that a high fish intake is cardioprotective only when that fish is not heavily contaminated with mercury.
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|Title Annotation:||myocardial infarction, the medical term for a heart attack|
|Author:||Moon, Mary Ann|
|Publication:||Internal Medicine News|
|Article Type:||Brief Article|
|Date:||Feb 1, 2003|
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