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Merck reports positive data from Keytruda phase three Keynote-181 oesophageal cancer trial.

M2 EQUITYBITES-November 16, 2018-Merck reports positive data from Keytruda phase three Keynote-181 oesophageal cancer trial


United States-based Merck's anti-PD-1 therapy, Keytruda (pembrolizumab), significantly improved overall survival rate in the phase three Keynote-181 oesophageal cancer trial, it was reported yesterday.

The phase 3 Keynote-181 study evaluating the product as monotherapy in the second-line treatment of advanced or metastatic oesophageal or oesophagogastric junction carcinoma has achieved a primary endpoint of overall survival in patients whose tumours expressed PD-L1.

The product is an anti-PD-1 therapy, which works by improving the ability of the body's immune system to help detect and inhibit tumour cells. It is a humanised monoclonal antibody that prohibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2, enabling to activate T lymphocytes that may affect both tumour cells and healthy cells. In the phase 3 Keynote-181 study, the patients treated with Keytruda indicated a statistically significant improvement in overall survival compared with patients treated with chemotherapy. The primary endpoint of overall survival was also evaluated in patients with squamous cell histology, in addition to the entire intention-to-treat study population.

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Publication:M2 EquityBites (EQB)
Date:Nov 16, 2018
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