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Merck ceases development of evofosfamide.

M2 PHARMA-December 9, 2015-Merck ceases development of evofosfamide

(C)2015 M2 COMMUNICATIONS

United States-based Merck has decided to halt the development of evofosfamide for advanced soft tissue sarcoma and advanced pancreatic adenocarcinoma, it was reported yesterday.

The company has taken this step after the drug candidate failed to meet its primary endpoints in two Phase III trials. The product failed to improve overall survival when integrated with chemotherapy in the two indications. It is an investigational hypoxia-activated prodrug of a bis-alkylating agent that is preferentially activated under severe tumour hypoxic conditions.

The company acquired the rights to develop the product from Threshold Pharmaceuticals in February 2012.

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Publication:M2 Pharma
Date:Dec 9, 2015
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