Printer Friendly

Medicinal plant may harbour HIV cure.

Byline: ANI

Washington, Nov 14 (ANI): A new UCLA AIDS Institute study has found that a chemical from the Astragalus root, frequently used in Chinese herbal therapy, may help in the fight against HIV.

Like other kinds of cells, immune cells lose the ability to divide as they age because a part of their chromosomes known as a telomere becomes progressively shorter with cell division. As a result, the cell changes in many ways, and its disease fighting ability is compromised.

But the new study has shown that the chemical, TAT2, can prevent or slow this progressive telomere shortening.

"This has the potential to be either added to or possibly even replace the HAART (highly active antiretroviral therapy), which is not tolerated well by some patients and is also costly," said study co-author Rita Effros, a professor of pathology and laboratory medicine at the David Geffen School of Medicine at UCLA and member of the UCLA AIDS Institute.

The researchers tested TAT2 in several ways. First, they exposed the CD8 T-cells from HIV-infected persons to TAT2 to see if the chemical not only slowed the shortening of the telomeres but also improved the cells'' production of soluble factors called chemokines and cytokines, which had been previously shown to inhibit HIV replication. And they found that it did.

They then took blood samples from HIV-infected individuals and separated out the CD8 T-cells and the CD4 T-cells - those infected with HIV.

They treated the CD8 T-cells with TAT2 and combined them with the CD4 T-cells in the dish-and found that the treated CD8 cells inhibited production of HIV by the CD4 cells.

"The ability to enhance telomerase activity and antiviral functions of CD8 T-lymphocytes suggests that this strategy could be useful in treating HIV disease, as well as immunodeficiency and increased susceptibility to other viral infections associated with chronic diseases or aging," the researchers said

The study is to be published in the Nov. 15 print edition of the Journal of Immunology. (ANI)

Copyright 2008 Asian News International (ANI) - All Rights Reserved.

Provided by an company
COPYRIGHT 2008 Al Bawaba (Middle East) Ltd.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2008 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:Asian News International
Date:Dec 3, 2008
Previous Article:Post-nups may offer couples more peace of mind than pre-nups.
Next Article:Aretha Franklin to perform at Obama's inaugural ceremony.

Related Articles
Natural medicine: pomegranate HIV/Aids fighter.
Top prof will help me find cure for Aids; HIV MIRACLE MAN LAUNCHES NEW TEST QUEST.
British man "cured" of AIDS?
Toxicity, microbial contamination, and anti-tumor activities of alnus rubra (red alder), a medicinal plant.
CURE HIV has patent on new low-cost, effective, nontoxic medication for prevention and treatment of HIV/AIDS.
ISENTRESSA (raltegravir), from MSD, was as Effective as Efavirenz at.
Medicinal plant may harbour HIV cure.

Terms of use | Privacy policy | Copyright © 2020 Farlex, Inc. | Feedback | For webmasters