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Measurement of lower-limb muscle spasticity: intrarater reliability of Modified Modified Ashworth scale.

INTRODUCTION

Upper motor neuron (UMN) syndrome occurs in multiple sclerosis (MS), stroke, spinal cord injuries, and cerebral palsy and can cause spasticity, which is common, complex, and disabling in many patients with these conditions. Spasticity affects at least 38 percent of people 12 months poststroke [1], and approximately 90 percent of people with MS experience spasticity at some point [2]. The definition provided by Lance describes spasticity as a velocity-dependent disorder of the stretch reflex that results in increased muscle tone as one component of UMN syndrome [3]. Measuring spasticity using reliable and valid tools is important for the evaluation of treatment efficacy. The Ashworth scale [4], Bohannon-Smith modified Ashworth scale [5], and Tardieu scales [6-9] are currently used to measure spasticity.

Currently, the Ashworth scales [4-5] are the most commonly used measures of spasticity in clinical practice and research. However, the reliability and validity of these scales has been recently challenged [10-16]. In an attempt to improve the quality of the Ashworth scales, Ansari et al. modified the Bohannon-Smith modified Ashworth scale, titling the new scale the Modified Modified Ashworth Scale (MMAS) [10]. In this modified version of the Ashworth scale, the grade is omitted and the grade "2" is redefined. In the MMAS, spasticity is scored on an ordinal scale from 0 to 4 as follows: 0 = No increase in muscle tone; 1 = Slight increase in muscle tone, manifested by a catch and release or by minimal resistance at the end of the range of motion when the affected part(s) is moved in flexion or extension; 2 = Marked increase in muscle tone, manifested by a catch in the middle range and resistance throughout the remainder of the range of motion, but affected part(s) easily moved; 3 = Considerable increase in muscle tone, passive movement difficult; and 4 = Affected part(s) rigid in flexion or extension.

The few studies performed on the reliability and validity of the MMAS have been encouraging. For the measurement of knee extensor spasticity in 15 patients after stroke, the MMAS demonstrated reliable inter- and intrarater reliability measurements. The kappa values were good between raters ([kappa] = 0.72, standard error [SE] = 0.14,p < 0.001) and very good within one rater ([kappa] = 0.82, SE = 0.12, p < 0.001) [17]. The interrater reliability for the MMAS was very good when evaluating wrist flexor spasticity in 30 patients with hemiplegia (weighted kappa [[[kappa].sub.w]] = 0.92, SE = 0.03, p < 0.001) [18]. In a study to investigate the interrater reliability of the MMAS in the assessment of elbow flexor spasticity, inexperienced raters tested 21 adult patients with stroke. The [[kappa].sub.w] was 0.81 (SE = 0.097, p = 0.0002), thus interrater reliability for two inexperienced raters was very good [19].

In a cross-sectional study to assess the interrater reliability of the MMAS in the upper limb of adult patients with hemiplegia, two physiotherapists rated two common spastic muscle groups (elbow flexors and wrist flexors) of 15 patients. The [[kappa].sub.w] was 0.61 for elbow flexors and 0.78 for wrist flexors. The interrater reliability of the MMAS was good [20].

To assess the interrater reliability of the MMAS in lower-limb muscle spasticity, Ghotbi et al. tested 22 adults with stroke or MS. Hip adductors, knee extensors, and ankle plantar flexors were assessed. Interrater reliability was very good for the hip adductors and the knee extensors [[kappa].sub.w] = 0.82, p < 0.001) and good for the ankle plantar flexors ([[kappa].sub.w] = 0.74,p < 0.001) [21].

One further study explored the validity of the MMAS in 27 patients with stroke. The relationship between the MMAS scores obtained from the wrist flexor muscle group and the [H.sub.Slope]/[M.sub.Slope] and [H.sub.Max]/[M.sub.Max] ratios was statistically significant (r = 0.39, p = 0.04) [22].

Few studies have investigated the reliability of the MMAS. Only one study to date has evaluated intrarater reliability. Therefore, the goal of the present study was to evaluate the intrarater reliability of the MMAS when several lower-limb muscle groups were assessed in patients with spasticity.

METHODS

Study Design

This study employed a test-retest design to evaluate the intrarater reliability of the MMAS in patients with lower limb spasticity.

Population

Patients with MS or stroke with spasticity were recruited from inpatient wards of Sina University Hospital, Tehran, Iran. To be included in the study, patients had to have no previous pathology of the affected lower limb and had to be able to understand simple commands. The exclusion criteria were muscle contracture and severe joint pain.

Rater

The rater was a physiotherapist with more than 16 years experience in managing patients with muscle spasticity. She was familiar with the MMAS but was not experienced using it. The descriptions of the rating criteria were included on the recording form.

Scale and Testing Position

The MMAS was the scale used. Three muscle groups in the affected lower limb of each patient were assessed: hip adductors, knee extensors, and ankle plantar flexors. The standardized test positions and movements are described in Table 1 and have been described and used in other studies [12,21].

Procedure

The procedure used in previous investigations was followed [12,21]. Demographic data including age, sex, etiology, affected side, and disease duration were recorded. The subjects were tested while in the hospital. The assessment order of limbs in cases of bilateral involvement in patients with MS was randomized; in all patients, the assessment order of the muscles was randomized. The same physiotherapist performed a second assessment 2 days after the first. Patients were instructed to relax during the test and to not resist the passive movements applied by the physiotherapist. The joints were moved with a fast-stretching velocity by counting "one-thousand-and-one" as suggested by Bohannon and Smith [5]. The passive movement was repeated three times at each joint.

Data Analysis

Descriptive statistics were calculated for subjects and variables with SPSS, version 11.5 (SPSS Inc; Chicago, Illinois). The quadratic weighted kappa statistic was used to calculate reliability. The reliability results were interpreted as follows [23]: very good 0.81-1.00, good 0.61-0.80, moderate 0.41-0.60, fair 0.21-0.41, and poor <0.21. The chi-square test was performed to analyze the difference between the weighted kappa values for each muscle group [24]. Statistical significance was set atp < 0.05.

RESULTS

Twenty-three patients (fourteen women, nine men) with a mean [+ or -] standard deviation (SD) age of 37.3 [+ or -] 14.1 years were examined in this study. Eighteen patients had MS and five patients had hemiplegia due to a single stroke. The mean [+ or -] SD ages of patients with stroke and MS were 61.6 [+ or -] 12.1 years and 33.1 [+ or -] 9.4 years, respectively. The mean [+ or -] SD time poststroke was 517.6 [+ or -] 1,138.9 days. The patients with MS had a mean [+ or -] SD history of MS of 2,615.7 [+ or -] 1,658.3 days. A total of 34 limbs were examined for intrarater reliability because eleven patients with MS were bilaterally involved. However, 101 muscle spasticity assessments were obtained because one patient found it difficult to stay in the side-lying position for the knee extensor muscle test. In this study, all MMAS grades from 0 to 4 were scored, but the patients were most often assigned the scores of 0 and 1 across all muscle groups. Most agreement was obtained for grade 0 followed by grade 1 (Table 2).

For hip adductor and knee extensor muscle groups, no subjects were graded 3 or 4. Patients were most often assigned grades of 0 and 1. For ankle plantar flexor muscles, the patients were mostly given grades of 2 and 1, but patients did attain scores of 3 and 4. Table 3 shows the weighted agreement for each of the muscles. The weighted kappa was moderate for the hip adductors, good for the knee extensors, and very good for the ankle plantar flexors. The kappa value for overall agreement was very good.

The chi-square test showed a significantly higher weighted kappa value for the ankle plantar flexors than for the hip adductors (p < 0.05). The difference between the weighted kappa values of the knee extensors and those of either hip adductors or ankle plantar flexors was not statistically significant.

DISCUSSION

The results of the present study demonstrated the intrarater reliability of the MMAS in measuring lowerlimb muscle spasticity in patients with neurological conditions. The overall reliability for lower-limb muscle spasticity was very good.

The rater in this study was not trained in the use of the MMAS. In actual clinical situations, very little time exists for training clinicians. Therefore, we offered no training to the rater. We also expected the training to be unnecessary because she was experienced in handling neurological patients and had previous experience using the Bohannon-Smith modified Ashworth scale [5].

So far, the findings on the reliability of the MMAS have been good and very good [17-21]. In this study, moderate reliability was observed for the hip adductors and good reliability for knee extensors; however, these are lower than previous measures of intrarater reliability [17]. One possible reason could be the clinical environment in the hospital. At times the hospital was not quiet. Muscle spasticity in patients with UMN lesions fluctuates because of environmental stimuli [25].

Another explanation for the lower reliability of the hip adductors could be the larger mass of the lower limb. The rater reported that the difference in the reliability for the hip adductors and ankle plantar flexors was because she had more control over the ankle.

Another possible reason for the lower reliability in this study was that the patients were undergoing medical treatment. This implies that the patients were not clinically stable. The unstable condition of the patients combined with medication usage could have affected the tone of the muscles.

Although these factors could have affected the consistency of the results on the reliability of the MMAS, the following points should also be considered. First, the intrarater reliability in this study was good and very good for the knee extensors and ankle plantar flexors. Second, the interrater reliability of the MMAS had been previously investigated by two inexperienced physiotherapy students in a hospital setting and very good agreement was found for each muscle and the overall weighted kappa [21]. In this investigation of intrarater reliability, the overall weighted kappa value for the three muscle groups was very good.

In patients with UMN lesions, multiple muscles in a limb are involved. Establishing reliability for individual muscle groups is important. However, reliable assessment of the entire affected limb is desirable, especially for clinical purposes. The overall agreement for the muscles in a limb gives a general idea about the reliability of the assessment. Therefore, the reliability of a scale in individual joints needs to be considered in light of the overall reliability obtained in the limb. In this study, the overall very good agreement for the muscles indicates the reliable assessment of spasticity for the limb has been achieved. Accordingly, the MMAS showed a high degree of intrarater reliability for lower-limb muscle spasticity among patients with neurological conditions that makes it suitable for initial evaluation and reassessment. However, we must note that the time interval between the two assessments was short and the rater could remember her original scores. The rater might have been influenced by her memory of the result of her first assessment.

CONCLUSIONS

The present study demonstrated that the MMAS has overall very good intrarater reliability in patients with lower-limb muscle spasticity. A statistically higher reliability for distal ankle plantar flexors than for proximal hip adductors was noted. The MMAS showed adequate reliability for the measurement of lower-limb muscle spasticity over time.

ACKNOWLEDGMENTS

Author Contributions:

Study concept and design: N. Nakhostin Ansari, N. Ghotbi. Analysis and interpretation of data: N. Nakhostin Ansari, N. Ghotbi, S. Naghdi, S. Hasson.

Drafting of manuscript: N. Ghotbi, N. Nakhostin Ansari, S. Naghdi. Study supervision: N. Ghotbi.

Statistical analysis: N. Nakhostin Ansari.

Critical revision of manuscript for important intellectual content: N. Nakhostin Ansari, S. Naghdi, S. Hasson.

Financial Disclosures: The authors have declared that no competing interests exist.

Funding/Support: This material was unfunded at the time of manuscript preparation.

Institutional Review: The project was approved by the Research Council of Rehabilitation Faculty of Tehran University of Medical Sciences. A general written informed consent was obtained from the patients for any test and examination for medical or research purposes. We additionally obtained verbal consent from the patients or caregivers once the study had been explained in detail.

Participant Follow-Up: The authors do not plan to inform participants of the publication of this study.

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Submitted for publication February 26, 2010. Accepted in revised form August 29, 2010.

This article and any supplementary material should be cited as follows:

Ghotbi N, Nakhostin Ansari N, Naghdi S, Hasson S. Measurement of lower-limb muscle spasticity: Intrarater reliability of Modified Modified Ashworth Scale. J Rehabil Res Dev. 2011;48(1):83-88. DOI:10.1682/JRRD.2010.02.0020

Nastaran Ghotbi, PhD, PT; (1) Noureddin Nakhostin Ansari, PhD, PT; (1) * Soofia Naghdi, PhD, PT; (1) Scott Hasson, EdD, PT (2)

(1) Faculty of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran; (2) Physical Therapy Department, Angelo State University, San Angelo, TX

Abbreviations: MMAS = Modified Modified Ashworth Scale, MS = multiple sclerosis, SD = standard deviation, SE = standard error, UMN = upper motor neuron.

* Address all correspondence to Dr. Noureddin Nakhostin Ansari, PhD, PT; Faculty of Rehabilitation, Tehran University of Medical Sciences, Enghelab Ave, Pitch-e-shemiran, 11489, PO Box 11155-1683, Tehran, Iran; +98-21-7753-3939; fax: +98-21-7788-2009. Email: nakhostin@sina.tums.ac.ir DOI:10.1682/JRRD.2010.02.0020
Table 1.
Standardized positions and movements for
rating with Modified Modified Ashworth Scale.

Muscle Group     Patient                     Rater

Hip Adductors    Supine, head in midline,    On side being tested,
                 and lower limbs in          rater placed one hand
                 extended position.          underneath limb close to
                                             knee and other hand
                                             supported limb close to
                                             ankle. Limb was moved
                                             into full abduction
                                             (without rotation).

Knee Extensors   Side-lying, with hips and   Behind patient, rater
                 knees in extension. Head    placed one hand just
                 and trunk aligned in        proximal to knee, on
                 straight line. Pillow can   lateral surface of thigh,
                 be used behind hips, if     to stabilize femur and
                 necessary, to stabilize     other hand just proximal
                 patient.                    to ankle. Knee was moved
                                             from maximum extension to
                                             maximum flexion.

Ankle Plantar    Supine, with head in        On side being tested,
Flexors          midline, and arms           rater placed one hand
                 alongside trunk. Lower      under ball of foot, while
                 limbs in extended           other hand stabilized
                 position.                   limb around ankle joint.
                                             Ankle was moved from
                                             maximum plantarflexion
                                             into maximum
                                             dorsiflexion.

Table 2.
Total assignments by rater for three lower-limb muscle groups using
Modified Modified Ashworth Scale (MMAS).

                  MMAS Scores: Assessment 2  Total
MMAS Scores:
Assessment 1    0     1     2     3     4

0              42     5     1     0     0      48
1              10    14     0     0     0      24
2               0     9     7     1     0      17
3               0     0     2     8     0      10
4               0     0     0     0     2       2
Total          52    28    10     9     2     101

Note: Overall [K.sub.w] = 0.87 (standard error = 0.03), p < 0.001.

Table 3.
Weighted agreement within rater (intrarater) in Modified Modified
Ashworth Scale scores for three muscle groups of lower limbs.

                        % Weighted
    Muscle Group        Agreement    [K.sub.w]    95% CI

Hip Adductors               89         0.45      0.13-0.77
Knee Extensors              96         0.62      0.39-0.85
Ankle Plantar Flexors       98         0.85      0.77-0.94
Overall                     98         0.87      0.81-0.93

    Muscle Group         SE    p-Value   Interpretation

Hip Adductors           0.16    0.007      Moderate
Knee Extensors          0.12   <0.001      Good
Ankle Plantar Flexors   0.05   <0.001      Very Good
Overall                 0.03   <0.001      Very Good

CI = confidence interval, SE = standard error.
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Article Details
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Author:Ghotbi, Nastaran; Ansari, Noureddin Nakhostin; Naghdi, Soofia; Hasson, Scott
Publication:Journal of Rehabilitation Research & Development
Article Type:Report
Geographic Code:7IRAN
Date:Jan 1, 2011
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